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Journal of Nephrology

, Volume 30, Issue 4, pp 461–475 | Cite as

Linking acute kidney injury to chronic kidney disease: the missing links

  • Mohammed A. Kaballo
  • Mohamed E. Elsayed
  • Austin G. StackEmail author
Review

Abstract

Acute kidney injury (AKI) is considered to be a major public health problem around the globe, and it is associated with major adverse clinical outcomes and significant health care costs. There is growing evidence suggesting that AKI is associated with the subsequent development of chronic kidney disease (CKD). While recovery of kidney function occurs in the majority of patients surviving an AKI episode, a large number of patients do not recover completely. Similarly, CKD is a well-known risk factor for the development of AKI. Recent studies suggest that both AKI and CKD are not separate disease entities but are in fact components of a far more closely interconnected disease continuum. However, the true nature of this relationship is complex and poorly understood. This review explores potential relationships between AKI and CKD, and seeks to uncover a number of “missing links” in this tentative emerging relationship.

Keywords

Acute kidney injury Chronic kidney disease Renal functional reserve 

Notes

Compliance with ethical standards

Conflict of interest

Authors have no relevant financial relationships to disclose.

Ethical approval

This article does not contain any studies with human participants performed by any of the authors.

Informed consent

For this type of study formal consent is not required.

References

  1. 1.
    Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P (2004) Acute renal failure–definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 8(4):R204PubMedPubMedCentralCrossRefGoogle Scholar
  2. 2.
    Kellum JA, Bellomo R, Ronco C (2007) The concept of acute kidney injury and the RIFLE criteria. Contrib Nephrol 156:10–16PubMedCrossRefGoogle Scholar
  3. 3.
    Mehta RL, Kellum JA, Shah SV et al (2007) Acute Kidney Injury Network (AKIN): report of an initiative to improve outcomes in acute kidney injury. Crit Care 11(2):R31PubMedPubMedCentralCrossRefGoogle Scholar
  4. 4.
    Levin A, Warnock DG, Mehta RL et al (2007) Improving outcomes from acute kidney injury: report of an initiative. Am J Kidney Dis 50(1):1–4PubMedCrossRefGoogle Scholar
  5. 5.
    Molitoris BA, Levin A, Warnock DG, Joannidis M, Mehta RL, Kellum JA, Ronco C, Shah S (2007) Improving outcomes from acute kidney injury. J Am Soc Nephrol 18(7):1992–1994PubMedCrossRefGoogle Scholar
  6. 6.
    Kidney Disease Outcomes Quality Initiative (2012) KDIGO Clinical practice guidelines for acute kidney injury. Kidney Int Suppl 2:1–38CrossRefGoogle Scholar
  7. 7.
    Ishani A, Xue JL, Himmelfarb J et al (2009) Acute kidney injury increases risk of ESRD among elderly. J Am Soc Nephrol 20(1):223–228PubMedPubMedCentralCrossRefGoogle Scholar
  8. 8.
    Triverio P-A, Martin P-Y, Romand J, Pugin J, Perneger T, Saudan P (2009) Long-term prognosis after acute kidney injury requiring renal replacement therapy. Nephrol Dial Transplant 24(7):2186–2189PubMedCrossRefGoogle Scholar
  9. 9.
    Mehta RL, Pascual MT, Soroko S et al (2004) Spectrum of acute renal failure in the intensive care unit: the PICARD experience. Kidney Int 66(4):1613–1621PubMedCrossRefGoogle Scholar
  10. 10.
    Mehta RL, Pascual MT, Soroko S, Chertow GM (2002) Diuretics, mortality, and nonrecovery of renal function in acute renal failure. JAMA 288(20):2547–2553PubMedCrossRefGoogle Scholar
  11. 11.
    Chawla LS, Amdur RL, Amodeo S, Kimmel PL, Palant CE (2011) The severity of acute kidney injury predicts progression to chronic kidney disease. Kidney Int 79(12):1361–1369PubMedPubMedCentralCrossRefGoogle Scholar
  12. 12.
    Amdur RL, Chawla LS, Amodeo S, Kimmel PL, Palant CE (2009) Outcomes following diagnosis of acute renal failure in U.S. veterans: focus on acute tubular necrosis. Kidney Int 76(10):1089–1097PubMedCrossRefGoogle Scholar
  13. 13.
    Lo LJ, Go AS, Chertow GM et al (2009) Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease. Kidney Int 76(8):893–899PubMedPubMedCentralCrossRefGoogle Scholar
  14. 14.
    Wald R, Quinn RR, Luo J et al (2009) Chronic dialysis and death among survivors of acute kidney injury requiring dialysis. J Am Med Assoc 302(11):1179–1185. (Erratum, JAMA 2009;302:1532)CrossRefGoogle Scholar
  15. 15.
    Bucaloiu ID, Kirchner HL, Norfolk ER, Hartle JE II, Perkins RM (2012) Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury. Kidney Int 81(5):477–485PubMedCrossRefGoogle Scholar
  16. 16.
    Wald R, Quinn RR, Adhikari NK et al (2012) Risk of chronic dialysis and death following acute kidney injury. Am J Med 125(6):585–593PubMedCrossRefGoogle Scholar
  17. 17.
    Chawla LS, Eggers PW, Star RA, Kimmel PL (2014) Acute kidney injury and chronic kidney disease as interconnected syndromes. New Engl J Med 371(1):58–66PubMedCrossRefGoogle Scholar
  18. 18.
    Bedford M, Farmer C, Levin A, Ali T, Stevens P (2012) Acute kidney injury and CKD: chicken or egg?. Am J Kidney Dis 59(4):485–491PubMedCrossRefGoogle Scholar
  19. 19.
    Bellomo R, Kellum JA, Ronco C (2012) Acute kidney injury. The Lancet 380:756–766CrossRefGoogle Scholar
  20. 20.
    Chawla LS, Kimmel PL (2012) Acute kidney injury and chronic kidney disease: an integrated clinical syndrome. Kidney Int 82:516–524PubMedCrossRefGoogle Scholar
  21. 21.
    Star RA (1998) Treatment of acute renal failure. Kidney Int 54:1817–1831PubMedCrossRefGoogle Scholar
  22. 22.
    Kheterpal S, Tremper KK, Heung M, Rosenberg AL, Englesbe M, Shanks AM et al (2009) Development and validation of an acute kidney injury risk index for patients undergoing general surgery: results from a national data set. Anesthesiology 110(3):505–515PubMedCrossRefGoogle Scholar
  23. 23.
    Bagshaw SM, George C, Bellomo R (2008) and the ANZICS database management committee. Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care 12:R47PubMedPubMedCentralCrossRefGoogle Scholar
  24. 24.
    Hoste EA, Clermont G, Kersten A et al (2006) RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care 10:R73PubMedPubMedCentralCrossRefGoogle Scholar
  25. 25.
    Xue JL, Daniels F, Star RA et al (2006) Incidence and mortality of acute renal failure in Medicare beneficiaries, 1992 to 2001. J Am Soc Nephrol 17:1135–1142PubMedCrossRefGoogle Scholar
  26. 26.
    Hsu CY, McCullough CE, Fan D, Ordonez JD, Cherow GM, Go AS (2007) Community-based incidence of acute renal failure. Kidney Int 72:208–212PubMedPubMedCentralCrossRefGoogle Scholar
  27. 27.
    Goldberg R, Dennen P (2008) Long-term outcomes of acute kidney injury. Adv Chronic Kidney Dis 15(3):297–307PubMedCrossRefGoogle Scholar
  28. 28.
    Panek R, Tennankore KK, Kiberd BA (2016) Incidence, etiology, and significance of acute kidney injury in the early post-kidney transplant period. Clin Transplant 30(1):66–70PubMedCrossRefGoogle Scholar
  29. 29.
    Wonnacott A, Meran S, Amphlett B, Talabani B, Phillips A (2014) Epidemiology and outcomes in community-acquired versus hospital-acquired AKI. Clin J Am Soc Nephrol 9(6):1007–1014PubMedPubMedCentralCrossRefGoogle Scholar
  30. 30.
    Susantitaphong P, Cruz DN, Cerda J, Abulfaraj M, Alqahtani F, Koulouridis I, Jaber BL (2013) Acute kidney injury advisory group of the american society of nephrology: world incidence of AKI: a meta-analysis. Clin J Am Soc Nephrol 8:1482–1493PubMedPubMedCentralCrossRefGoogle Scholar
  31. 31.
    Thomas M, Davies A, Dawnay A (2013) Acute kidney injury prevention, detection and management of acute kidney injury up to the point of renal replacement therapy. NICE Clinical GuidelinesGoogle Scholar
  32. 32.
    Kidney Disease Statistics for the United States (2016) National kidney and urologic diseases information clearinghouse (NKUDIC). http://kidney.niddk.nih.gov/kudiseases/pubs/kustats/#17. Accessed 11 Feb 2016
  33. 33.
    Saran R, Li Y, Robinson B et al (2016) US renal data system 2015 AnnuaL DATA REPORT: EPIDEMIOLOGY OF KIDNEY DISEAse in the United States. Am J Kidney Dis 67(3 suppl 1):S1–S434Google Scholar
  34. 34.
    Brück K, Stel VS, Gambaro G, Hallan S, Völzke H, Ärnlöv J, Kastarinen M, Guessous I, Vinhas J, Stengel B, Brenner H, Chudek J, Romundstad S, Tomson C, Gonzalez AO, Bello AK, Ferrieres J, Palmieri L, Browne G, Capuano V, Van Biesen W, Zoccali C, Gansevoort R, Navis G, Rothenbacher D, Ferraro PM, Nitsch D, Wanner C, Jager KJ; European CKD Burden Consortium (2016) CKD prevalence varies across the european general population. J Am Soc Nephrol 27(7):2135–2147PubMedCrossRefGoogle Scholar
  35. 35.
    Centers for Disease Control and Prevention (2016) Deaths and mortality. http://www.cdc.gov/nchs/fastats/deaths.htm. Accessed 18 Feb 2016
  36. 36.
    Eknoyan G, Levin NW (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification-foreword. Am J Kidney Dis 39(2):S14–266CrossRefGoogle Scholar
  37. 37.
    Hsu CY, Vittinghoff E, Lin F, Shlipak MG (2004) The incidence of end-stage renal disease is increasing faster than the prevalence of chronic renal insufficiency. Ann Intern Med 141(2):95–101PubMedCrossRefGoogle Scholar
  38. 38.
    Coca SG, Singanamala S, Parikh CR (2012) Chronic kidney disease after acute kidney injury: a systematic review and metaanalysis. Kidney Int 81:442–448PubMedCrossRefGoogle Scholar
  39. 39.
    Ishani A, Nelson D, Clothier B, Schult T, Nugent S, Greer N et al (2011) The magnitude of acute serum creatinine increase after cardiac surgery and the risk of chronic kidney disease, progression of kidney disease, and death. Arch Intern Med 171:226–233PubMedCrossRefGoogle Scholar
  40. 40.
    Newsome BB, Warnock DG, McClellan WM, Herzog CA, Kiefe CI, Eggers PW, Allison JJ (2008) Long-term risk of mortality and end-stage renal disease among the elderly after small increases in serum creatinine level during hospitalization for acute myocardial infarction. Arch Inter Med 168(6):609–616CrossRefGoogle Scholar
  41. 41.
    James MT, Ghali WA, Tonelli M, Faris P, Knudtson ML, Pannu N, Klarenbach SW, Manns BJ, Hemmelgarn BR (2010) Acute kidney injury following coronary angiography is associated with a long-term decline in kidney function. Kidney Int 78(8):803–809PubMedCrossRefGoogle Scholar
  42. 42.
    James MT, Hemmelgarn BR, Wiebe N et al (2010) Glomerular filtration rate, proteinuria, and the incidence and consequences of acute kidney injury: a cohort study. Lancet 376:2096–2103PubMedCrossRefGoogle Scholar
  43. 43.
    Hsu CY, Chertow GM, McCulloch CE et al (2009) Nonrecovery of kidney function and death after acute on chronic renal failure. Clin J Am Soc Nephrol 4:891–898PubMedPubMedCentralCrossRefGoogle Scholar
  44. 44.
    Lafrance JP, Djurdjev O, Levin A (2010) Incidence and outcomes of acute kidney injury in a referred chronic kidney disease cohort. Nephrol Dial Transplant 25(7):2203–2209PubMedCrossRefGoogle Scholar
  45. 45.
    Choi AI, Li Y, Parikh C, Volberding PA, Shlipak MG (2010) Long-term clinical consequences of acute kidney injury in the HIV-infected. Kidney Int 78(5):478–485PubMedPubMedCentralCrossRefGoogle Scholar
  46. 46.
    James MT, Ghali WA, Knudtson ML, Ravani P, Tonelli M, Faris P, Pannu N, Manns BJ, Klarenbach SW, Hemmelgarn BR (2011) Associations between acute kidney injury and cardiovascular and renal outcomes after coronary angiography. Circulation 123(4):409–416PubMedCrossRefGoogle Scholar
  47. 47.
    Thakar CV, Christianson A, Himmelfarb J, Leonard AC (2011) Acute kidney injury episodes and chronic kidney disease risk in diabetes mellitus. Clin J Am Soc Nephrol 6:2567–2572PubMedPubMedCentralCrossRefGoogle Scholar
  48. 48.
    Steinwald B, Dummit LA (1989) Hospital case-mix change: sicker patients or DRG creep?. Health Affairs 8(2):35–47PubMedCrossRefGoogle Scholar
  49. 49.
    Vlasschaert ME, Bejaimal SA, Hackam DG, Quinn R, Cuerden MS, Oliver MJ et al (2011) Validity of administrative database coding for kidney disease: a systematic review. Am J Kidney Dis 57:29–43PubMedCrossRefGoogle Scholar
  50. 50.
    Bonventre JV (2010) Pathophysiology of AKI: injury and normal and abnormal repair. In: Cardiorenal syndromes in critical care 2010 Apr 20, vol 165. Karger Publishers, Berlin, pp 9–17Google Scholar
  51. 51.
    Yang L, Humphreys BD, Bonventre JV (2011) Pathophysiology of acute kidney injury to chronic kidney disease: maladaptive repair. In: Controversies in acute kidney injury 2011 Sep 9, vol 174. Karger Publishers, Berlin, pp 149–155Google Scholar
  52. 52.
    Zuk A, Bonventre JV, Brown D, Matlin KS (1998) Polarity, integrin, and extracellular matrix dynamics in the postischemic rat kidney. Am J Physiol 275:C711–C731PubMedGoogle Scholar
  53. 53.
    Thadhani R, Pascual M, Bonventre JV (1996) Acute renal failure. New Engl J Med 334:1448–1460PubMedCrossRefGoogle Scholar
  54. 54.
    Kwon O, Hong SM, Ramesh G (2009) Diminished NO generation by injured endothelium and loss of macula densa nNOS may contribute to sustained acute kidney injury after ischemia–reperfusion. Am J Physiol Renal Physiol 296(1):F25–F33PubMedCrossRefGoogle Scholar
  55. 55.
    Conger J (1997) Hemodynamic factors in acute renal failure. Adv Ren Replace Ther 4(suppl 1):25–37PubMedGoogle Scholar
  56. 56.
    Conger JD (1983) Vascular abnormalities in the maintenance of acute renal failure. Circ Shock 11:235–244PubMedGoogle Scholar
  57. 57.
    Linas S, Whittenburg D, Repine JE (1997) Nitric oxide prevents neutrophil-mediated acuterenal failure. Am J Physiol 272:F48–F54PubMedGoogle Scholar
  58. 58.
    Pulskens WP, Teske GJ, Butter LM, Roelofs JJ, van der Poll T, Florquin S, Leemans JC (2008) Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury. PloS One 3:e3596PubMedPubMedCentralCrossRefGoogle Scholar
  59. 59.
    Leemans JC, Stokman G, Claessen N, Rouschop KM, Teske GJ, Kirschning CJ, Akira S, van der Poll T, Weening JJ, Florquin S (2005) Renal-associated TLR2 mediates ischemia/ reperfusion injury in the kidney. J Clin Invest 115:2894–2903PubMedPubMedCentralCrossRefGoogle Scholar
  60. 60.
    Kelly KJ, Williams WW, Colvin RB, Bonventre JV (1994) Antibody to intercellular adhesion molecule-1 protects the kidney against ischemic injury. Proc Natl Acad Sci USA 91:812–816PubMedPubMedCentralCrossRefGoogle Scholar
  61. 61.
    Kelly KJ, Williams WW, Colvin RB, Meehan SM, Springer TA, Gutierrez-Ramos JC, Bonventre JV (1996) Intercellular adhesion molecule-1-deficient mice are protected against renal ischemia. J Clin Invest 97:1056–1063PubMedPubMedCentralCrossRefGoogle Scholar
  62. 62.
    Homeister JW, Lucchesi BR (1994) Complement activation and inhibition in myocardial ischemia and reperfusion injury. Annu Rev Pharmacol Toxicol 34:17–40PubMedCrossRefGoogle Scholar
  63. 63.
    Reis e Sousa C (2006) Dendritic cells in a mature age. Nat Rev Immunol 6:476–483PubMedCrossRefGoogle Scholar
  64. 64.
    Park KM, Chen A, Bonventre JV (2001) Prevention of kidney ischemia/reperfusion-induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatment. J Biol Chem 276:11870–11876PubMedCrossRefGoogle Scholar
  65. 65.
    Basile DP, Fredrich K, Chelladurai B, Leonard EC, Parrish AR (2008) Renal ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1, a novel VEGF inhibitor. Am J Physiol Renal Physiol 294(4):F928–F936PubMedCrossRefGoogle Scholar
  66. 66.
    Zouggari Y, Ait-Oufella H, Waeckel L, Vilar J, Loinard C, Cochain C, Recalde A, Duriez M, Levy BI, Lutgens E, Mallat Z, Silvestre JS (2009) Regulatory T cells modulate postischemic neovascularization. Circulation 120:1415–1425PubMedCrossRefGoogle Scholar
  67. 67.
    Humphreys BD, Valerius MT, Kobayashi A, Mugford JW, Soeung S, Duffield JS, McMahon AP, Bonventre JV (2008) Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2:284–291PubMedCrossRefGoogle Scholar
  68. 68.
    Forbes JM, Hewitson TD, Becker GJ, Jones CL (2000) Ischemic acute renal failure: long- term histology of cell and matrix changes in the rat. Kidney Int 57:2375–2385PubMedCrossRefGoogle Scholar
  69. 69.
    Macedo E, Bouchard J, Mehta RL (2008) Renal recovery following acute kidney injury. Curr Opin Crit Care 14:660–665PubMedCrossRefGoogle Scholar
  70. 70.
    Venkatachalam MA, Griffin KA, Lan R, Geng H, Saikumar P, Bidani AK (2010) Acute kidney injury: a springboard for progression in chronic kidney disease. Am J Physiol Renal Physiol 298(5):F1078–F1094PubMedPubMedCentralCrossRefGoogle Scholar
  71. 71.
    Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV (2010) Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med 16(5):535–543PubMedPubMedCentralCrossRefGoogle Scholar
  72. 72.
    Akhtar A (2015) The flaws and human harms of animal experimentation. Cambr Q Healthc Ethics 24(04):407–419CrossRefGoogle Scholar
  73. 73.
    National Kidney Foundation (2002) K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 39(2):S1–S266CrossRefGoogle Scholar
  74. 74.
    Levey AS, Eckardt KU, Tsukamoto Y, Levin A, Coresh J, Rossert J, Zeeuw DD, Hostetter TH, Lameire N, Eknoyan G (2005) Definition and classification of chronic kidney disease: a position statement from kidney disease: improving global outcomes (KDIGO). Kidney Int 67(6):2089–2100PubMedCrossRefGoogle Scholar
  75. 75.
    Preddie DC, Markowitz GS, Radhakrishnan J, Nickolas TL, D’Agati VD, Schwimmer JA, Gardenswartz M, Rosen R, Appel GB (2006) Mycophenolate mofetil for the treatment of interstitial nephritis. Clin J Am Soc Nephrol 1(4):718–722PubMedCrossRefGoogle Scholar
  76. 76.
    Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW (2005) Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol 16(11):3365–3370PubMedCrossRefGoogle Scholar
  77. 77.
    Hobson CE, Yavas S, Segal MS et al (2009) Acute kidney injury is associated with increased long-term mortality after cardiothoracic surgery. Circulation 119:2444–2453PubMedCrossRefGoogle Scholar
  78. 78.
    Waikar SS, Liu KD, Chertow GM (2008) Diagnosis, epidemiology and outcomes of acute kidney injury. Clin J Am Soc Nephrol 3:844–861PubMedCrossRefGoogle Scholar
  79. 79.
    Lafrance JP, Miller DR (2010) Defining acute kidney injury in database studies: the effects of varying the baseline kidney function assessment period and considering CKD status. Am J Kidney Dis 56:651–660PubMedCrossRefGoogle Scholar
  80. 80.
    Lin J, Fernandez H, Shashaty MG, Negoianu D, Testani JM, Berns JS, Parikh CR, Wilson FP (2015) False-positive rate of AKI using consensus creatinine-based criteria. Clin J Am Soc Nephrol 10:1723–1731PubMedPubMedCentralCrossRefGoogle Scholar
  81. 81.
    Ejaz AA, Dass B, Lingegowda V, Shimada M, Beaver TM, Ejaz NI, Abouhamze AS, Johnson RJ (2013) Effect of uric acid lowering therapy on the prevention of acute kidney injury in cardiovascular surgery. Int Urol Nephrol 45:449–458PubMedCrossRefGoogle Scholar
  82. 82.
    Wilson FP, Shashaty M, Testani J, Aqeel I, Borovskiy Y, Ellenberg SS, Feldman HI, Fernandez H, Gitelman Y, Lin J, Negoianu D, Parikh CR, Reese PP, Urbani R, Fuchs B (2015) Automated, electronic alerts for acute kidney injury: a single-blind, parallel-group, randomised controlled trial. Lancet 385:1966–1974PubMedPubMedCentralCrossRefGoogle Scholar
  83. 83.
    Tumlin JA, Finkel KW, Murray PT, Samuels J, Cotsonis G, Shaw AD (2005) Fenoldopam mesylate in early acute tubular necrosis: a randomized, double-blind, placebo-controlled clinical trial. Am J Kidney Dis 46:26–34PubMedCrossRefGoogle Scholar
  84. 84.
    Berger MM, Soguel L, Shenkin A, Revelly JP, Pinget C, Baines M, Chiólero R (2008) Influence of early antioxidant supplements on clinical evolution and organ function in critically ill cardiac surgery, major trauma, and subarachnoid hemorrhage patients. Crit Care 12:R101. doi: 10.1186/cc6981 PubMedPubMedCentralCrossRefGoogle Scholar
  85. 85.
    Herget-Rosenthal S, Pietruck F, Volbracht L, Philipp T, Kribben A (2005) Serum cystatin C–a superior marker of rapidly reduced glomerular filtration after uninephrectomy in kidney donors compared to creatinine. Clin Nephrol 64(1):41–46PubMedCrossRefGoogle Scholar
  86. 86.
    Bagshaw SM, Mortis G, Doig CJ, Godinez-Luna T, Fick GH, Laupland KB (2006) One-year mortality in critically ill patients by severity of kidney dysfunction: a population-based assessment. Am J Kidney Dis 48:402–409PubMedCrossRefGoogle Scholar
  87. 87.
    Chertow GM, Soroko SH, Paganini EP, Cho KC, Himmelfarb J, Ikizler TA, Mehta RL (2006) Mortality after acute renal failure: models for prognostic stratification and risk adjustment. Kidney Int 70:1120–1126PubMedCrossRefGoogle Scholar
  88. 88.
    Lafrance JP, Miller DR (2010) Acute kidney injury associates with increased long-term mortality. J Am Soc Nephrol 21:345–352PubMedPubMedCentralCrossRefGoogle Scholar
  89. 89.
    Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Ronco C (2005) Beginning and ending supportive therapy for the kidney (BEST kidney) Investigators: acute renal failure in critically ill patients: A multinational, multicenter study. J Am Med Assoc 294:813–818CrossRefGoogle Scholar
  90. 90.
    Waikar SS, Betensky RA, Emerson SC, Bonventre JV (2012) Imperfect gold standards for kidney injury biomarker evaluation. J Am Soc Nephrol 23:13–21PubMedPubMedCentralCrossRefGoogle Scholar
  91. 91.
    Ricci Z, Cruz D, Ronco C (2008) The RIFLE criteria and mortality in acute kidney injury: a systematic review. Kidney Int 73(5):538–546PubMedCrossRefGoogle Scholar
  92. 92.
    Friedrich JO, Adhikari N, Herridge MS, Beyene J (2005) Metaanalysis: low-dose dopamine increases urine output but does not prevent renal dysfunction or death. Ann Intern Med 142(7):510–524PubMedCrossRefGoogle Scholar
  93. 93.
    Bellomo R, Kellum JA, Ronco C (2004) Defining acute renal failure: physiological principles. Intensive Care Med 30:33–37. doi: 10.1007/s00134-003-2078-3 PubMedCrossRefGoogle Scholar
  94. 94.
    Bosch JP, Lauer A, Glabman S (1984) Short-term protein loading in assessment of patients with renal disease. Am J Med 77:873–879PubMedCrossRefGoogle Scholar
  95. 95.
    Bosch JP, Saccaggi A, Lauer A, Ronco C, Belledonne M, Glabman S (1983) Renal functional reserve in humans. Effect of protein intake on glomerular filtration rate. Am J Med 75:943–950PubMedCrossRefGoogle Scholar
  96. 96.
    Bosch JP, Lew S, Glabman S, Lauer A (1986) Renal hemodynamic changes in humans. Response to protein loading in normal and diseased kidneys. Am J Med 81:809–815PubMedCrossRefGoogle Scholar
  97. 97.
    Ronco C, Brendolan A, Bragantini L, Chiaramonte S, Fabris A, Feriani M, Dell Aquila R, Milan M, Mentasti P, La Greca G (1988) Renal functional reserve in pregnancy. Nephrol Dial Transplant 3:157–161PubMedCrossRefGoogle Scholar
  98. 98.
    Der Mesropian P, Othersen J, Mason D, Wang J, Asif A, Mathew RO (2016) Community acquired acute kidney injury: a challenge and opportunity for primary care in kidney health. Nephrology (Carlton) 21(9):729–735. doi: 10.1111/nep.12751 CrossRefGoogle Scholar
  99. 99.
    Kaufman J, Dhakal M, Patel B, Hamburger R (1991) Community-acquired acute renal failure. Am J Kidney Dis 17(2):191–198PubMedCrossRefGoogle Scholar
  100. 100.
    Liano F, Pascual J (1996) Epidemiology of acute renal failure: a prospective, multicenter, community-based study. Madrid acute renal failure study group. Kidney Int 50(3):811–818PubMedCrossRefGoogle Scholar
  101. 101.
    Talabani B, Zouwail S, Pyart RD, Meran S, Riley SG, Phillips AO (2014) Epidemiology and outcome of community-acquired acute kidney injury. Nephrology (Carlton) 19(5):2827CrossRefGoogle Scholar
  102. 102.
    Obialo CI, Okonofua EC, Tayade AS, Riley LJ (2000) Epidemiology of de novo acute renal failure in hospitalized African Americans: comparing community-acquired vs hospital-acquired disease. Arch Intern Med 160(9):1309–1313PubMedCrossRefGoogle Scholar
  103. 103.
    Schissler MM, Zaidi S, Kumar H, Deo D, Brier ME, McLeish KR (2013) Characteristics and outcomes in community-acquired versus hospital-acquired acute kidney injury. Nephrology (Carlton) 18(3):183–187. doi: 10.1111/nep.12036 CrossRefGoogle Scholar
  104. 104.
    Der Mesropian PJ, Kalamaras JS, Eisele G, Phelps KR, Asif A, Mathew RO (2014) Long-term outcomes of community-acquired versus hospital-acquired acute kidney injury: a retrospective analysis. Clin Nephrol 81(3):174–184CrossRefGoogle Scholar
  105. 105.
    Xu G, Player P, Shepherd D, Brunskill NJ (2016) Identifying acute kidney injury in the community—a novel informatics approach. J Nephrol 29(1):93–98PubMedCrossRefGoogle Scholar
  106. 106.
    Egan BM, Zhao Y, Axon RN (2010) US trends in prevalence, awareness, treatment, and control of hypertension, 1988–2008. J Am Med Assoc 303(20):2043–2050CrossRefGoogle Scholar
  107. 107.
    Pascual J, Liaño F, Ortuño J (1995) The elderly patient with acute renal failure. J Am Soc Nephrol 6(2):144–153PubMedGoogle Scholar
  108. 108.
    U.S. Renal Data System (2016) USRDS 2007 annual data report. Bethesda, MD: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 2007. https://www.usrds.org/atlas07.aspx. Accessed 1 Mar 2016
  109. 109.
    Levey AS, Coresh J (2012) Chronic kidney disease. Lancet 379:165–180PubMedCrossRefGoogle Scholar
  110. 110.
    Go AS, Parikh CR, Ikizler TA et al (2010) The Assessment, Serial Evaluation, and Subsequent Sequelae of Acute Kidney Injury (ASSESS-AKI) study: design and methods. BMC Nephrol 11:22PubMedPubMedCentralCrossRefGoogle Scholar
  111. 111.
    Horne KL, Packington R, Monaghan J, Reilly T, McIntyre CW, Selby NM (2014) The effects of acute kidney injury on long-term renal function and proteinuria in a general hospitalised population. Nephron Clin Pract 128:192–200PubMedCrossRefGoogle Scholar
  112. 112.
    Hoy WE, Hughson MD, Bertram JF, Douglas-Denton R, Amann K (2005) Nephron number, hypertension, renal disease, and renal failure. J Am Soc Nephrol 16:2557–2564. doi: 10.1681/ASN.2005020172 PubMedCrossRefGoogle Scholar
  113. 113.
    Keller G, Zimmer G, Mall G, Ritz E, Amann K (2003) Nephron number in patients with primary hyper-tension. N Engl J Med 348:101–108. doi: 10.1056/NEJMoa020549 PubMedCrossRefGoogle Scholar
  114. 114.
    McNamara BJ, Diouf B, Douglas-Denton RN, Hughson MD, Hoy WE, Bertram JF (2010) A comparison of nephron number, glomerular volume and kidney weight in Senegalese Africans and African Ameri-cans. Nephrol Dial Transplant 25:1514–1520. doi: 10.1093/ndt/gfq030 PubMedPubMedCentralCrossRefGoogle Scholar
  115. 115.
    Hinchliffe SA, Sargent PH, Howard CV, Chan YF, van Velzen D (1991) Human intrauterine renal growth expressed in absolute number of glomeruli assessed by the disector method and cavalieri principle. Lab Invest 64:777–784PubMedGoogle Scholar
  116. 116.
    Hughson M, Farris AB, Douglas-Denton R, Hoy WE, Bertram JF (2003) Glomerular number and size in autopsy kidneys: the relationship to birth weight. Kidney Int 63:2113–2122. doi: 10.1046/j.1523-1755.2003.00018.x PubMedCrossRefGoogle Scholar
  117. 117.
    Manalich R, Reyes L, Herrera M, Melendi C, Fundora I (2000) Relationship between weight at birth and the number and size of renal glomeruli in hu-mans: a histomorphometric study. Kidney Int 58:770–773. doi: 10.1046/j.1523-1755.2000.00225.x PubMedCrossRefGoogle Scholar
  118. 118.
    McNamara BJ, Diouf B, Hughson MD, Douglas-Denton RN, Hoy WE, Bertram JF (2008) Renal pathology, glomerular number and volume in a West African urban community. Nephrol Dial Transplant 23:2576–2585. doi: 10.1093/ndt/gfn039 PubMedPubMedCentralCrossRefGoogle Scholar
  119. 119.
    McNamara BJ, Diouf B, Hughson MD, Hoy WE, Bertram JF (2009) Associations between age, body size and nephron number with individual glomerular volumes in urban West African males. Nephrol Dial Transplant 24:1500–1506. doi: 10.1093/ndt/gfn636 PubMedCrossRefGoogle Scholar
  120. 120.
    Nyengaard JR, Bendtsen TF (1992) Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat Rec 232:194–201. doi: 10.1002/ar.1092320205 PubMedCrossRefGoogle Scholar
  121. 121.
    Rodriguez MM, Gomez AH, Abitbol CL, Chandar JJ, Duara S, Zilleruelo GE (2004) Histomorphometric analysis of postnatal glomerulogenesis in extremely preterm infants. Pediatr Dev Pathol 7:17–25. doi: 10.1007/s10024-003-3029-2 PubMedCrossRefGoogle Scholar
  122. 122.
    Zimanyi MA, Hoy WE, Douglas-Denton RN, Hughson MD, Holden LM, Bertram JF (2009) Nephron number and individual glomerular volumes in male Caucasian and African American subjects. Nephrol Dial Transplant 24:2428–2433. doi: 10.1093/ndt/gfp116 PubMedPubMedCentralCrossRefGoogle Scholar
  123. 123.
    Brenner BM, Garcia DL, Anderson S (1988) Glomeruli and blood pressure. Less of one, more the other? Am J Hypertens 1:335–347PubMedCrossRefGoogle Scholar
  124. 124.
    Luyckx VA, Shukha K, Brenner BM (2011) Low nephron number and its clinical consequences. Rambam Maimonides Med J 2(4):e0061PubMedPubMedCentralCrossRefGoogle Scholar
  125. 125.
    Vehaskari VM, Aviles DH, Manning J (2001) Prenatal programming of adult hypertension in the rat. Kidney Int 59:238–245. doi: 10.1046/j.1523-17552001.00484.x PubMedCrossRefGoogle Scholar
  126. 126.
    Baum M (2010) Role of the kidney in the prenatal and early postnatal programming of hypertension. Am J Physiol Renal Physiol 298:F235–F247. doi: 10.1152/ajprenal.00288.2009 PubMedCrossRefGoogle Scholar
  127. 127.
    Bhathena DB, Julian BA, McMorrow RG, Baehler RW (1985) Focal sclerosis of hypertrophied glomeruli in solitary functioning kidneys of humans. Am J Kidney Dis 5:226–232PubMedCrossRefGoogle Scholar
  128. 128.
    McMillen IC, Robinson JS (2005) Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev 85:571–633. doi: 10.1152/physrev.00053.2003 PubMedCrossRefGoogle Scholar
  129. 129.
    White SL, Perkovic V, Cass A et al (2009) Is low birth weight an antecedent of CKD in later life? A systematic review of observational studies. Am J Kidney Dis 54:248–261. doi: 10.1053/j.ajkd.2008.12.042 PubMedCrossRefGoogle Scholar
  130. 130.
    Hoy WE, Rees M, Kile E, Mathews JD, McCredie DA, Pugsley DJ, Wang Z (1998) Low birthweight and renal disease in Australian aborigines. Lancet 352:1826–1827PubMedCrossRefGoogle Scholar
  131. 131.
    Hoy WE, Wang Z, VanBuynder P, Baker PR, Mathews JD (2001) The natural history of renal disease in Australian aborigines: part 1. Changes in albuminuria and glomerular filtration rate over time. Kidney Int 60:243–248PubMedCrossRefGoogle Scholar
  132. 132.
    Hoy WE, Mathews JD, McCredie DA, Pugsley DJ, Hayhurst BG, Rees M, Kile E, Walker KA, Wang Z (1998) The multidimensional nature of renal disease: rates and associations of albuminuria in an Australian aboriginal community. Kidney Int 54:1296–1304PubMedCrossRefGoogle Scholar
  133. 133.
    Hoy WE, Rees M, Kile E, Mathews JD, Wang Z (1999) A new dimension to the Barker hypothesis: low birthweight and susceptibility to renal disease. Kidney Int 56:1072–1077PubMedCrossRefGoogle Scholar
  134. 134.
    Nelson RG, Morgenstern H, Bennett PH (1998) Birth weight and renal disease in Pima Indians with type 2 diabetes mellitus. Am J Epidemiol 148:650–656PubMedCrossRefGoogle Scholar
  135. 135.
    Yudkin JS, Martyn CN, Phillips DI, Gale CR (2001) Associations of micro-albuminuria with intra-uterine growth retardation. Nephron 89:309–314PubMedCrossRefGoogle Scholar
  136. 136.
    Painter RC, Roseboom TJ, van Montfrans GA, Bossuyt PM, Krediet RT, Osmond C, Barker DJ, Bleker OP (2005) Microalbuminuriain adults after prenatal exposure to the Dutch famine. J Am Soc Nephrol 16:189–194PubMedCrossRefGoogle Scholar
  137. 137.
    Hayslett JP (1979) Functional adaptation to reduction in renal mass. Physiol Rev 59:137–164PubMedGoogle Scholar
  138. 138.
    Deen WM, Maddox DA, Robertson CR, Br en ner B (1974) Dynamics of glomerular ultrafiltration in the rat. VII: response to reduced renal mass. Am J Physiol 227:556–562PubMedGoogle Scholar
  139. 139.
    Kaufman JM, Siegel NJ, Hayslett JP (1975) Functional and hemodynamic adaptation to progressive renal ablation. Circ Res 36:286–293PubMedCrossRefGoogle Scholar
  140. 140.
    Purkerson ML, Hoffsten PE, Klahr S (1976) Pathogenesis of the glomerulopathy associated with renal infarction in rats. Kidney Int 9(5):407–417PubMedCrossRefGoogle Scholar
  141. 141.
    Morrison AB (1966) Experimental chronic renal insufficiency. Methods Achiev Exp Pathol 1:455–475Google Scholar
  142. 142.
    Shea SM, Raskova J, Morrison AB (1978) A stereologic study of glomerular hypertrophy in the subtotally nephrectomized rat. Am J Pathol 90(1):201PubMedPubMedCentralGoogle Scholar
  143. 143.
    Shimamura T, Morrison AB (1975) A progressive glomerulosclerosis occurring in partial five-sixths nephrectomized rats. Am J Pathol 79(1):95PubMedPubMedCentralGoogle Scholar
  144. 144.
    Brenner BM, Lawler EV, Mackenzie HS (1996) The hyperfiltration theory: a paradigm shift in nephrology. Kidney Int 49(6):1774–1777PubMedCrossRefGoogle Scholar
  145. 145.
    Lam AQ, Bonventre JV (2015) Regenerating the nephron with human pluripotent stem cells. Curr Opin Organ Transplant 20(2):187–192PubMedCrossRefGoogle Scholar
  146. 146.
    Coca SG, King JT Jr, Rosenthal RA, Perkal MF, Parikh CR (2010) The duration of postoperative acute kidney injury is an additional parameter predicting long-term survival in diabetic veterans. Kidney Int 78(9):926–933PubMedPubMedCentralCrossRefGoogle Scholar
  147. 147.
    Palevsky PM, Liu KD, Brophy PD, Chawla LS, Parikh CR, Thakar CV, Tolwani AJ, Waikar SS, Weisbord SD (2013) KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury. Am J Kidney Dis 61(5):649–672PubMedCrossRefGoogle Scholar
  148. 148.
    Schreuder MF, Langemeijer ME, Bokenkamp A, Delemarre-Van de Waal HA, Van Wijk JA (2008) Hypertension and microalbuminuria in children with congenital solitary kidneys. J Paediatr Child Health 44:363–368. doi: 10.1111/j.1440-1754.2008.01315.x PubMedCrossRefGoogle Scholar

Copyright information

© Italian Society of Nephrology 2016

Authors and Affiliations

  • Mohammed A. Kaballo
    • 1
    • 2
  • Mohamed E. Elsayed
    • 1
    • 2
  • Austin G. Stack
    • 1
    • 2
    • 3
    • 4
    Email author
  1. 1.Division of Nephrology, Department of MedicineUniversity Hospital LimerickLimerickIreland
  2. 2.Graduate Entry Medical SchoolUniversity of LimerickLimerickIreland
  3. 3.Health Research InstituteUniversity of LimerickLimerickIreland
  4. 4.Chair of MedicineUniversity Hospital LimerickLimerickIreland

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