Advertisement

L'Endocrinologo

, Volume 15, Issue 3, pp 112–117 | Cite as

Sindrome post-finasteride: tra mito e realtà

  • Alessandro Pizzocaro
  • Giovanna Motta
  • Luciano Negri
  • Pierpaolo Graziotti
Rassegna
  • 81 Downloads

Sommario

Numerosi studi hanno dimostrato l’associazione tra l’uso di finasteride e la comparsa di disfunzioni sessuali e sindrome depressiva, che possono persistere dopo la sospensione del farmaco (Sindrome post-finasteride). I ridotti livelli di DHT e dei metaboliti della 5AR ad azione neuroattiva, in aree del SNC fondamentali per l’attività sessuale e il tono dell’umore, sembrerebbero essere i responsabili della sindrome. In questo lavoro viene caratterizzata la sindrome, al fine di migliorarne la gestione.

Parole chiave

Finasteride Inibitori 5-alfa reduttasi Disfunzione erettile Sindrome post-finasteride 

Notes

Conflitto di interesse

Gli autori Alessandro Pizzocaro, Giovanna Motta, Luciano Negri e Pierpaolo Graziotti dichiarano di non avere conflitti di interessi.

Consenso informato

Lo studio presentato in questo articolo non ha richiesto sperimentazione umana.

Studi sugli animali

Gli autori di questo articolo non hanno eseguito studi sugli animali.

Supplementary material

40619_2014_44_MOESM1_ESM.doc (26 kb)
(DOC 27 kB)
40619_2014_44_MOESM2_ESM.doc (25 kb)
(DOC 25 kB)

Bibliografia

  1. 1.
    Traish AM, Hassani J, Guay AT et al. (2011) Adverse side effects of 5α-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients. J Sex Med 8:872–884 PubMedCrossRefGoogle Scholar
  2. 2.
    Mella JM, Perret MC, Manzotti M et al. (2010) Efficacy and safety of finasteride therapy for androgenetic alopecia: a systematic review. Arch Dermatol 146:1141–1150 PubMedCrossRefGoogle Scholar
  3. 3.
    Gur S, Kadowitz PJ, Hellstrom WJ (2013) Effects of 5-alpha reductase inhibitors on erectile function, sexual desire and ejaculation. Expert Opin Drug Saf 12:81–90 PubMedCrossRefGoogle Scholar
  4. 4.
    Erdemir F, Harbin A, Hellstrom WJ (2008) 5-alpha reductase inhibitors and erectile dysfunction: the connection. J Sex Med 5:2917–2924 PubMedCrossRefGoogle Scholar
  5. 5.
    Wessells H, Roy J, Bannow J et al. (2003) Incidence and severity of sexual adverse experiences in finasteride and placebo-treated men with benign prostatic hyperplasia. Urology 61:579–584 PubMedCrossRefGoogle Scholar
  6. 6.
    Irwig MS, Kolukula S (2011) Persistent sexual side effects of finasteride for male pattern hair loss. J Sex Med 8:1747–1753 PubMedCrossRefGoogle Scholar
  7. 7.
    Irwig MS (2012) Persistent sexual side effects of finasteride: could they be permanent? J Sex Med 9:2927–2932 PubMedCrossRefGoogle Scholar
  8. 8.
    Pinsky MR, Gur S, Tracey AJ et al. (2011) The effects of chronic 5-alpha-reductase inhibitor (dutasteride) treatment on rat erectile function. J Sex Med 8:3066–3074 PubMedCrossRefGoogle Scholar
  9. 9.
    Charalampopoulos I, Remboutsika E, Margioris AN, Gravanis A (2008) Neurosteroids as modulators of neurogenesis and neuronal survival. Trends Endocrinol Metab 19:300–307 PubMedCrossRefGoogle Scholar
  10. 10.
    Irwig MS (2012) Depressive symptoms and suicidal thoughts among former users of finasteride with persistent sexual side effects. J Clin Psychiatry 73:1220–1223 PubMedCrossRefGoogle Scholar
  11. 11.
    Mondaini N, Gontero P, Giubilei G et al. (2007) Finasteride 5 mg and sexual side effects: how many of these are related to a nocebo phenomenon? J Sex Med 4:1708–1712 PubMedCrossRefGoogle Scholar
  12. 12.
    Rosen RC, Wei JT, Althof SE et al. BPH Registry and Patient Survey Steering Committee (2009) Association of sexual dysfunction with lower urinary tract symptoms of BPH and BPH medical therapies: results from the BPH Registry. Urology 73:562–566 PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2014

Authors and Affiliations

  • Alessandro Pizzocaro
    • 1
  • Giovanna Motta
    • 2
  • Luciano Negri
    • 3
  • Pierpaolo Graziotti
    • 1
  1. 1.U.O. Urologia, Servizio di AndrologiaIstituto Clinico Humanitas IRCCSRozzanoItalia
  2. 2.S.C.D.U. Endocrinologia, Diabetologia e Metabolismo, Dipartimento Scienze MedicheUniversità di TorinoTorinoItalia
  3. 3.U.O. Medicina della RiproduzioneIstituto Clinico Humanitas IRCCRozzanoItalia

Personalised recommendations