Journal of Endocrinological Investigation

, Volume 39, Issue 8, pp 917–922 | Cite as

The relationship between visfatin and serum concentrations of C-reactive protein, interleukin 6 in patients with metabolic syndrome

  • M. J. Hosseinzadeh-AttarEmail author
  • A. Golpaie
  • M. Foroughi
  • F. Hosseinpanah
  • S. Zahediasl
  • F. Azizi
Original Article



To evaluate the relationship between inflammatory and pro inflammatory markers, with obesity and visceral adiposity in male subjects with or without metabolic syndrome (MS).

Subjects and methods

A total of 37 patients with MS and 37 age matched controls were included (mean age 46.35 ± 1.6 years). MS was defined by the criteria of the international diabetes federation 2005. Anthropometric and biochemical profiles, including high-sensitivity C-reactive protein (Hs-CRP), visfatin and interleukin 6 (IL-6), were measured. Data were compared between groups by using t test. Pearson’s correlation was used to evaluate the relationship between variables. P values less than 0.05 were considered as statistically significant.


In patients with MS, CRP and IL-6 were significantly correlated with body mass index, waist circumference and waist to hip ratio. Visfatin levels were significantly lower in patients with MS compared to controls (log visfatin: 1.74 ± 0.27 vs. 1.86 ± 0.13 ng/ml, MS vs. control group respectively). We cannot find any significant correlation between visfatin, CRP and IL-6. Also there were no correlation between visfatin levels and any anthropometric parameters in patients with MS or control groups.


Serum visfatin was lower in patients with MS. Therefore it seems that visfatin could not be considered as a pro inflammatory adipocytokine in MS. The positive associations of obesity and visceral adiposity with elevated CRP and IL-6 levels suggest the importance of reducing visceral adiposity to prevent the risk of coronary disease.


Metabolic syndrome Visceral adiposity Visfatin IL-6 CRP 



Body mass index


Blood pressure


Coronary heart disease


C-reactive protein


Cardiovascular diseases


Enzyme-linked immunosorbent assay


Enzyme immunoassay


Fasting plasma glucose


High-sensitivity C-reactive protein


Interleukin 6


International diabetes federation


Metabolic syndrome




Tumor necrosis factor-alpha


Tehran lipid and glucose study


Waist to hip ratio


Waist circumference



We thank all persons who participated in this study. We also thank Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences for this collaboration within the framework of the Tehran lipid and glucose study (TLGS). This piece of research was granted by Tehran University of Medical Sciences, Tehran, Iran (grant number: 6068).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study was approved by the ethics committee of Shahid Beheshti University of Medical Sciences.

Informed consent

Written informed consent was obtained from all subjects.


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Copyright information

© Italian Society of Endocrinology (SIE) 2016

Authors and Affiliations

  • M. J. Hosseinzadeh-Attar
    • 1
    Email author
  • A. Golpaie
    • 2
  • M. Foroughi
    • 2
  • F. Hosseinpanah
    • 3
  • S. Zahediasl
    • 4
  • F. Azizi
    • 5
  1. 1.Department of Clinical Nutrition, School of Nutritional Sciences and DieteticsTehran University of Medical SciencesTehranIran
  2. 2.Department of Nutrition and Biochemistry, School of Public HealthTehran University of Medical SciencesTehranIran
  3. 3.Obesity Research Center, Research Institute for Endocrine SciencesShahid Beheshti University of Medical SciencesTehranIran
  4. 4.Endocrine Research Center, Research Institute for Endocrine SciencesShahid Beheshti University of Medical SciencesTehranIran
  5. 5.Obesity Research Center and Endocrine Research Center, Research Institute for Endocrine SciencesShahid Beheshti University of Medical ScienceTehranIran

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