Relation of resistin to proprotein convertase subtilisin–kexin type 9 levels in coronary artery disease patients with different nutritional status
To investigate the association of resistin with proprotein convertase subtilisin–kexin type 9 (PCSK9) levels, another novel regulator of atherosclerosis, in the condition of coronary artery disease (CAD).
Research design and methods
We prospectively enrolled a total of 356 consecutive stable CAD patients who were not treated with lipid-lowering drugs in the present study. The baseline clinical characteristics were collected. Plasma PCSK9 and resistin levels were determined by ELISA. The relationship between plasma PCSK9 and resistin levels was investigated.
Overall, plasma resistin exhibited a positive nonparametric correlation with PCSK9 levels (r = 0.123, p = 0.02). When the patients were classified into groups based on body mass index (BMI), the resistin correlated significantly to the PCSK9 levels in patients with BMI < 25 kg/m2 (r = 0.162, p = 0.026) but not in patients with BMI ≥ 25 kg/m2 (r = 0.087, p = 0.205). Multivariate regression analysis corroborated the relation between the PCSK9 and an elevated resistin level in patients with BMI < 25 kg/m2 independently of traditional parameters including age, sex, BMI, smoking, family history of CAD, systolic blood pressure, glucose, low density lipoprotein cholesterol, white blood cell, neutrophil to lymphocyte ratio, and high-sensitive C-reactive protein.
Plasma resistin was positively related to PCSK9 levels in CAD patients with normal weight, suggesting that the circulating resistin might represent a link with PCSK9 level variations in CAD progression of normal body weight.
KeywordsProprotein convertase subtilisin/kexin type 9 Resistin Coronary artery disease Obesity
Coronary artery disease
Body mass index
Systolic blood pressure
Diastolic blood pressure
Low density lipoprotein cholesterol
High density lipoprotein cholesterol
White blood cell
Neutrophil to lymphocyte ratio
High-sensitive C-reactive protein
Proprotein convertase subtilisin/kexin type 9