Surgical menopause versus natural menopause and cardio-metabolic disturbances: A 12-year population-based cohort study
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Menopausal status exposes women to increased risk of cardiovascular disease. This study was performed to compare the effect of menopausal types, including surgical and natural, on metabolic syndrome and other metabolic disorders 3 years before and after menopause.
Of 437 postmenopausal women, who participated in the Tehran Lipid and Glucose Study, 13 women with surgical menopause and 39 age-matched controls with natural menopause were selected. During the follow-up period, changes in metabolic and biochemical profiles were compared between surgical and natural menopause women.
Odds of incidence of metabolic syndrome in surgical menopause women, compared to natural menopause women, was 9.7 (95 % CI 1.8–51.8).
Metabolic disturbances after menopause are highly influenced by type of menopause and are more prevalent in those undergoing surgical menopause.
KeywordsNatural menopause Surgical menopause Metabolic syndrome Tehran Lipid and Glucose Study
We appreciate the substantial time and effort the study participants contributed to this study. Acknowledgments are also due to research staff at the Tehran Lipid and Glucose Study Unit and staff of the Research Endocrine Laboratory. Also we thank Mrs. N. Shiva for critical editing of English grammar and syntax of the manuscript. We thank the National Council of Scientific Research of the Islamic Republic of Iran for approval of this project and for its funding as a national research project.
Conflict of interest
The authors declare that there are no competing interests and that the source of funding is independent of the objectives and results found in this study.
Ethical code: 750 EC 90/11/16. The ethical review board of the Research Institute for Endocrine Sciences approved the study proposal.
Informed consent was obtained from all subjects.
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