Journal of Endocrinological Investigation

, Volume 38, Issue 1, pp 81–89 | Cite as

Twelve-month treatment with Liraglutide ameliorates Visceral Adiposity Index and common cardiovascular risk factors in type 2 diabetes outpatients

  • G. T. RussoEmail author
  • A. M. Labate
  • A. Giandalia
  • E. L. Romeo
  • P. Villari
  • A. Alibrandi
  • G. Perdichizzi
  • D. Cucinotta
Original Article



In addition to the effects on glycemic control and body weight, GLP-1 receptor agonists may favorably affect other major cardiovascular disease (CVD) risk factors, although currently available data are still sparse. In this retrospective study, we evaluated the effects of 12-month treatment with liraglutide on major CVD risk factors in 115 type 2 diabetes outpatients (60 men and 55 women), on stable hypoglycemic, anti-hypertensive and/or lipid-lowering therapy.


Clinical and anthropometric data, metabolic and lipid profile, as well as the Visceral Adiposity Index (VAI), an obesity-related CVD risk factor, were measured in all participants at baseline and after 12-month treatment.


Treatment with liraglutide was associated with a significant reduction from baseline values of fasting blood glucose (−42.1 mg/dl, P < 0.05), HbA1c (−1.5 %, −17 mmol/mol, P < 0.05), body weight (−7.1 kg, P < 0.05), waist circumference (-6.8 cm, P < 0.001), total-cholesterol (−27.4 mg/dl, P < 0.05), LDL-cholesterol (−25.4 mg/dl, P < 0.05), triglycerides (−56.1 mg/dl, P < 0.05), and non-HDL-C (−36.6 mg/dl, P < 0.05) and an increase of HDL-cholesterol concentrations (+9.3 mg/dl, P < 0.001), a significant reduction in both systolic and diastolic blood pressure (−14.7 mmHg, P < 0.001 and −9.0 mmHg, P < 0.05, respectively) and a decrease of VAI values (−1.6, P < 0.001). All these differences were independent of changes in BMI and comparable in men and women.


In conclusion, 12-month treatment with liraglutide in add-on to on-going hypoglycemic therapy significantly ameliorates all major CVD risk factors and reduces cardiometabolic risk, as estimated by VAI values.


Liraglutide Type 2 diabetes Visceral Adiposity Index Lipids Blood pressure 



Cardiovascular disease


Type 2 diabetes


Glucagon-like peptide-1 receptor agonists


Visceral Adiposity Index


Conflict of interest

No conflicts of interest exist.

Supplementary material

40618_2014_163_MOESM1_ESM.docx (36 kb)
Supplementary material 1 (DOCX 35 kb)


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Copyright information

© Italian Society of Endocrinology (SIE) 2014

Authors and Affiliations

  • G. T. Russo
    • 1
    Email author
  • A. M. Labate
    • 1
  • A. Giandalia
    • 1
  • E. L. Romeo
    • 1
  • P. Villari
    • 1
  • A. Alibrandi
    • 2
  • G. Perdichizzi
    • 1
  • D. Cucinotta
    • 1
  1. 1.Department of Clinical and Experimental Medicine, Policlinico Universitario G. MartinoUniversity of MessinaMessinaItaly
  2. 2.Department of Economical, Business and Environmental Sciences and Quantitative MethodsUniversity of MessinaMessinaItaly

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