Journal of Endocrinological Investigation

, Volume 37, Issue 8, pp 739–744 | Cite as

Relationship between glucose metabolism and non-alcoholic fatty liver disease severity in morbidly obese women

  • Giorgio Bedogni
  • Amalia Gastaldelli
  • Claudio Tiribelli
  • Fiorenza Agosti
  • Alessandra De Col
  • Rezene Fessehatsion
  • Alessandro Sartorio
Original Article



Non-alcoholic fatty liver disease (NAFLD) is an independent predictor of type 2 diabetes mellitus (T2DM). Insulin resistance and beta-cell dysfunction are involved in the pathogenesis of T2DM. Insulin resistance is associated with NAFLD but little is known about beta-cell dysfunction and NAFLD.


We tested whether NAFLD severity is associated with insulin sensitivity and beta-cell function in morbidly obese women.

Subjects and methods

We studied 61 Caucasian women aged 18–60 years without T2DM and with a body mass index ranging from 35.3 to 48.8 kg/m2. The insulin sensitivity index (ISI) and the disposition index (DI) from oral glucose tolerance testing were used as measures of insulin sensitivity and beta-cell function, respectively. Fat was measured by dual-energy X-ray absorptiometry. Fatty liver was diagnosed by ultrasonography and ordinally coded as 0 = none, 1 = light, 2 = moderate, 3 = severe. Proportional-odds logistic regression was used to evaluate the association of NAFLD severity with logeISI and logeDI with and without correction for total and truncal fat.


The odds of more severe vs. less severe NAFLD decreased for increasing logeISI [odds ratio (OR) 0.40, 95 % CI 0.19–0.84, p < 0.05] and logeDI (OR 0.80, 95 % CI 0.69–0.92, p < 0.01). Neither total nor truncal fat had any effect on these associations.


In morbidly obese women, NAFLD severity is inversely associated with insulin sensitivity and beta-cell function. The association of NAFLD severity with beta-cell dysfunction is stronger than that with insulin resistance.


Non-alcoholic fatty liver disease Obesity Body composition Body fat Dual-energy X-ray absorptiometry Oral glucose tolerance testing Insulin resistance Beta-cell function 


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Copyright information

© Italian Society of Endocrinology (SIE) 2014

Authors and Affiliations

  • Giorgio Bedogni
    • 1
    • 2
  • Amalia Gastaldelli
    • 3
  • Claudio Tiribelli
    • 1
  • Fiorenza Agosti
    • 4
  • Alessandra De Col
    • 4
  • Rezene Fessehatsion
    • 5
  • Alessandro Sartorio
    • 4
    • 5
  1. 1.Liver Research Center, AREA Science ParkTriesteItaly
  2. 2.International Center for the Assessment of Nutritional Status (ICANS)University of MilanoMilanItaly
  3. 3.Istituto di Fisiologia Clinica, Consiglio Nazionale delle Ricerche (CNR)PisaItaly
  4. 4.Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-Endocrinological ResearchMilanoItaly
  5. 5.Istituto Auxologico Italiano, IRCCS, Division of Metabolic DiseasesVerbaniaItaly

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