Journal of Endocrinological Investigation

, Volume 37, Issue 9, pp 783–788 | Cite as

Review of the protective effects of rutin on the metabolic function as an important dietary flavonoid

  • Hossein Hosseinzadeh
  • Marjan Nassiri-AslEmail author



In recent years, flavonoids have been revealed to be helpful in the treatment of many diseases. Rutin (3,3′,4′,5,7-pentahydroxyflavone-3-rhamnoglucoside) is an important flavonoid that is consumed in the daily diet. It is also known as vitamin P and quercetin-3-O-rutinoside. In addition, it is found in many food items, vegetables, and beverages. The cytoprotective effects of rutin, including gastroprotective, hepatoprotective, and anti-diabetic effects, have been shown in several studies. Furthermore, rutin has several pharmacological effects such as anti-inflammatory and anti-glycation activities.


This work reviewed characteristic, pharmacokinetic, and metabolic effects of rutin in all experimental and human studies.


Based on the above summarized effects of rutin, this flavonoid appears to be a potent component that could be considered in the treatment of several gastrointestinal diseases and diabetes.


Rutin Hepatoprotective Anti-diabetes Anti-glycation 


Conflict of interest

The authors declare that there are no conflicts of interest.


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Copyright information

© Italian Society of Endocrinology (SIE) 2014

Authors and Affiliations

  1. 1.Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, School of PharmacyMashhad University of Medical SciencesMashhadIslamic Republic of Iran
  2. 2.Cellular and Molecular Research Centre, Department of Pharmacology, School of MedicineQazvin University of Medical SciencesQazvinIslamic Republic of Iran

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