Journal of Endocrinological Investigation

, Volume 37, Issue 3, pp 229–232

The effect of zoledronic acid on the fracture risk in men with osteoporosis

Short Review

DOI: 10.1007/s40618-013-0038-5

Cite this article as:
Spiegel, R., Nawroth, P.P. & Kasperk, C. J Endocrinol Invest (2014) 37: 229. doi:10.1007/s40618-013-0038-5



Prospective, placebo-controlled, double-blind, randomized studies on osteoporosis treatment with bisphosphonates in men are rare. This review focuses on a recent trial and compares the results with other studies.


This review provides a summary of recent literature on fracture risk in men following treatment with zoledronic acid. According to a recent clinical study with 1,199 men, zoledronic acid was linked to a lower risk of vertebral fractures. In this manuscript, a re-analysis of the presented statistical data will be demonstrated by performing a Bonferroni-correction to adjust for type 1 error accumulation in multiple statistical tests.


It will be shown that the provided evidence linking zoledronic acid to a lower fracture risk in male osteoporosis is true, but less pronounced than originally assumed.


Comparative clinical studies are recommended, where the benefits of different bisphosphonates are compared to each other under the same experimental conditions.


Zoledronic acid Osteoporosis Bisphosphonates Fractures Comparative studies 

Copyright information

© Italian Society of Endocrinology (SIE) 2014

Authors and Affiliations

  1. 1.Department of Medicine I and Clinical ChemistryUniversity of HeidelbergHeidelbergGermany

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