Journal of Endocrinological Investigation

, Volume 37, Issue 2, pp 175–180

Serum interferon gamma concentration is associated with bone mineral density in overweight boys

  • L. Utsal
  • V. Tillmann
  • M. Zilmer
  • J. Mäestu
  • P. Purge
  • M. Saar
  • E. Lätt
  • T. Jürimäe
  • K. Maasalu
  • J. Jürimäe
Original Article

DOI: 10.1007/s40618-013-0029-6

Cite this article as:
Utsal, L., Tillmann, V., Zilmer, M. et al. J Endocrinol Invest (2014) 37: 175. doi:10.1007/s40618-013-0029-6

Abstract

Childhood obesity has recently been linked to low-grade inflammation. Overweight children have slightly different processes of bone accumulation than normal weight children. The possible links between inflammation and bone accumulation have not previously been assessed in overweight children.

Aims

An exploratory study to assess whether common inflammatory markers are associated with the development of obesity and bone accumulation in childhood.

Methods

Thirteen different inflammatory markers in serum were measured in 38 boys with BMI >85th centile (overweight) and 38 boys with normal BMI (normal weight), aged 10–11 years. Total body (TB) and lumbar spine (LS) bone mineral density (BMD), bone mineral content (BMC) were measured by DXA. TB BMC for height, TB and LS bone mineral apparent density (BMAD) were calculated.

Results

Overweight boys had higher mean TB and LS BMD, TB BMC and TB BMC for height, but lower mean TB BMAD (all p < 0.05) than normal weight boys. Serum interferon gamma (IFNγ) concentration was significantly (p < 0.05) correlated with TB BMD (r = 0.36), TB BMC (r = 0.38) and TB BMC for height (r = 0.53) in the broader overweight group (n = 38). In obese boys (BMI > 95 centile, n = 36) IFNγ was correlated with LS BMD (r = 0.38).

Conclusion

The positive correlation between serum INFγ concentration and BMD suggests that the inflammatory process, already involved in the early stage of obesity, may also affect bone accumulation. Further studies are needed to clarify the role of INFγ as a possible link between adipose tissue and bone health.

Keywords

Inflammation Obesity Bone mineral density Bone mineral content Boys Cytokines Overweight BMI 

Copyright information

© Italian Society of Endocrinology (SIE) 2013

Authors and Affiliations

  • L. Utsal
    • 1
  • V. Tillmann
    • 2
  • M. Zilmer
    • 3
  • J. Mäestu
    • 1
  • P. Purge
    • 1
  • M. Saar
    • 1
  • E. Lätt
    • 1
  • T. Jürimäe
    • 1
  • K. Maasalu
    • 4
  • J. Jürimäe
    • 1
  1. 1.Faculty of Exercise and Sport SciencesUniversity of TartuTartuEstonia
  2. 2.Department of Paediatrics, Faculty of MedicineUniversity of TartuTartuEstonia
  3. 3.Department of Biochemistry, Faculty of MedicineCentre of Excellence for Translational Medicine, University of TartuTartuEstonia
  4. 4.Department of Traumatology and Orthopaedics, Faculty of MedicineUniversity of TartuTartuEstonia

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