Goal-Striving Stress Is Associated with Chronic Kidney Disease Among Participants in the Jackson Heart Study

  • Loretta R. CainEmail author
  • LáShauntá Glover
  • Bessie Young
  • Mario Sims



Research that assesses the relationship between psychosocial factors and chronic kidney disease (CKD) among African Americans (AAs) is limited. Using the Jackson Heart Study (JHS) cohort data, we investigated the association of goal-striving stress (GSS)—the stress experienced from not reaching goals—with prevalent CKD among AAs.


This was a cross-sectional analysis of JHS exam 1 data that assessed the relationship between GSS and CKD.

Setting and Participants

We utilized a sample from the JHS (n = 4967), an AA sample of women and men, 35–84 years old from the Jackson, MS metro area.

Main Outcome Measures

The baseline relationship between GSS levels (low, moderate, and high) and CKD (eGFR < 60 mL/min/1.73m2) was evaluated using a logistic regression model to estimate odds ratios (OR) on a 95% confidence interval (CI). The final model was adjusted for sex, age, socioeconomic status, health behaviors, risk factors, and total stress.


After full adjustment, the odds of prevalent CKD increased by 52% (OR 1.52; 95% CI 1.04, 2.24) for those reporting high (versus low) GSS.


Deficiencies between goal aspiration and achievement were associated with prevalent CKD. Potential interventions might consider the impact GSS contributes to prevalent CKD.


Goal-striving stress Stress Kidney disease Psychonephrology African Americans Blacks Jackson Heart Study (JHS) 



We wish to thank all participants of the Jackson Heart Study for their time, effort, and dedication towards this study. The abstract was presented at the American Heart Association Scientific Sessions 2017 in Anaheim, CA.


The Jackson Heart Study (JHS) is supported and conducted in collaboration with Jackson State University (HHSN268201300049C and HHSN268201300050C), Tougaloo College (HHSN268201300048C), and the University of Mississippi Medical Center (HHSN268201300046C and HHSN268201300047C) contracts from the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute on Minority Health and Health Disparities (NIMHD). Dr. Sims is supported by the grants P60MD002249 and (Ms. Glover) U54MD008176 from NIMHD; 15SFDRN26140001 and P50HL120163 from the American Heart Association. This study was also supported by Dr. Young’s National Institutes of Health (NIH) National Institute of Diabetes, Digestive, and Kidney Disease grant 1R01DK102134-01. Dr. Young is also supported, in part, by funding from the Veterans Affairs Puget Sound Health Care System.

Compliance with Ethical Standards

Informed Consent

Informed consent was obtained from all individual participants included in the study.


The authors declare that they have no conflicts of interest.


The Veterans Affairs does not endorse any of the statements or opinions advocated by this manuscript. The views expressed in this manuscript are those of the authors and do not necessarily represent the views of the National Heart, Lung, and Blood Institute; the National Institutes of Health; or the U.S. Department of Health and Human Services. The funders had no role in the study design, collection, analysis, interpretation of data, writing the report, or the decision to submit the report for publication.


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Copyright information

© W. Montague Cobb-NMA Health Institute 2018

Authors and Affiliations

  • Loretta R. Cain
    • 1
    Email author
  • LáShauntá Glover
    • 2
  • Bessie Young
    • 3
    • 4
  • Mario Sims
    • 2
  1. 1.Department of Data ScienceUniversity of Mississippi Medical CenterJacksonUSA
  2. 2.Department of MedicineUniversity of Mississippi Medical CenterJacksonUSA
  3. 3.Division of Nephrology and Kidney Research InstituteUniversity of WashingtonSeattleUSA
  4. 4.Veterans Affairs, Hospital and Specialty Medicine and Center for InnovationSeattleUSA

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