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Racial and Ethnic Trends in Prostate Cancer Incidence and Mortality in Philadelphia, PA: an Observational Study

  • Charnita Zeigler-Johnson
  • Scott Keith
  • Russell McIntire
  • Tashika Robinson
  • Amy Leader
  • Karen Glanz
Article

Abstract

Background

To learn more about local prostate cancer (PCa) disparities, we conducted descriptive analyses of the role of race and age in PCa using the Pennsylvania Cancer Registry data for Philadelphia (2005–2014).

Methods

We focused on the most prevalent race/ethnic groups: white (33%), black (44%), and Hispanic (9%). Outcomes included PCa rates, tumor stage, and tumor grade. Percent change was used to describe changes in age-adjusted incidence and mortality rates. Frequency tables and logistic regression models were used to describe trends in proportions of advanced PCa by race and time. Race-by-time interaction terms were retained in the models if statistically significant.

Results

PCa incidence was highest for black men over time. Incidence rates declined over time for all race groups (− 28% for white men to − 38% for Hispanic men). PCa mortality rates declined in a less universal manner (− 5% for blacks to − 32% for whites). Each year, odds increased across all race groups for advanced tumor stage (4% each year among white and Hispanic men and 9% each year among black men) and for advanced tumor grade (4% each year among white and black men and 23% each year among Hispanic men). Among younger men, black men experienced significantly increased odds of advanced tumor stage each year (8%) and Hispanics experienced significantly increased odds of advanced tumor grade each year (30%).

Conclusions

Black men remain at highest PCa risk relative to other racial/ethnic groups in Philadelphia. Younger black and Hispanic men are at particular risk for advanced PCa at diagnosis.

Keywords

Prostate cancer trends Philadelphia Race/ethnicity 

Abbreviations

PCa

Prostate cancer

USPSTF

United States Preventive Services Task Force

EDDIE

Enterprise Data Dissemination Informatics Exchange

PSA

Prostate specific antigen

RAIRs

Risk-adjusted incidence rates

Notes

Authors’ contributions

CZJ acquired data; was responsible for the study concept/design, analysis, and interpretation; and drafted the manuscript. SK assisted with data analysis and interpretation and revised the manuscript. RM revised the manuscript. TR was responsible for the data analysis and revised the manuscript. AL revised the manuscript. KG was responsible for the study concept and revised the manuscript.

Funding

This study was funded by the Department of Defense (DOD W81XWH-15-1-0693). However, the DOD did not play a role in the study design, analysis, interpretation of results, or writing of the manuscript.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict interests.

Ethics Approval and Consent to Participate

This observational study based upon Pennsylvania Cancer Registry data was approved by the Institutional Review Board (IRB) at Thomas Jefferson University (Philadelphia, PA). The IRB reference number is 15G.337. Informed consent was waived by the review board.

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Copyright information

© W. Montague Cobb-NMA Health Institute 2018

Authors and Affiliations

  1. 1.Department of Medical Oncology, Division of Population Science, Sidney Kimmel Cancer CenterThomas Jefferson UniversityPhiladelphiaUSA
  2. 2.Department of Pharmacology and Experimental TherapeuticsThomas Jefferson UniversityPhiladelphiaUSA
  3. 3.College of Population HealthThomas Jefferson UniversityPhiladelphiaUSA
  4. 4.Center for Epidemiology and BiostatisticsUniversity of PennsylvaniaPhiladelphiaUSA

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