Psychological Outcomes After a False Positive Mammogram: Preliminary Evidence for Ethnic Differences Across Time

  • Yamile Molina
  • Shirley A. A. Beresford
  • Beti Thompson
Article

Abstract

Adverse psychological consequences of screening mammography are well-documented for women who receive a false positive result. However, little is known about ethnic differences. To address this gap, we examine distress associated with an abnormal mammogram (results-related distress) and perceived lifetime risk of breast cancer (perceived risk) among Latinas and non-Latina White (NLW) women 3 months after receipt of a false positive result. A sample of 28 Latina and 27 NLW women who received an initial abnormal mammogram result and later, a definitive non-cancer diagnosis were recruited for this descriptive, longitudinal study. Women were interviewed twice: within 30 days and 3 months after a false positive result. Questionnaires included standard sociodemographic questions, the Impact of Events Scale-Revised, and two perceived breast cancer risk items. All participants experienced decreased distress 3 months after the initial results. Latinas experienced higher levels of distress, F(1,45) = 4.58, p = 0.04, and had a significant increase in perceived breast cancer risk over time, F(1,45) = 3.99, p = 0.05. Larger population-based studies are necessary to confirm ethnic differences in mental health consequences of false positive results. Given cultural emphases concerning respect for authority figures, healthcare professionals may be particularly helpful in working with Latinas to mitigate distress and clarify accurate perceptions of breast cancer risk through evidence-based practice.

Keywords

Breast cancer Risk Distress Abnormal mammogram Latinas 

Notes

Acknowledgments

We thank Noah Espinoza and Blair Beadnell for their technical assistance with this project.

Compliance with Ethical Standards

The authors have no conflicts to disclose. Research involved human participants. All content and procedures were approved by the Fred Hutchinson Cancer Research Center’s Institutional Review Board.

Funding statement

This work was supported by the National Cancer Institute under grant numbers P50CA148143 and R25CA92408. Y.M. was also supported by the University of Illinois Cancer Center and University of Illinois-Chicago Center for Research on Women and Gender.

References

  1. 1.
    Miller A, Wall C, Baines C, Sun P, To T, Narod S. Twenty-five year follow-up for breast cancer incidence and mortality of the Canadian National Breast Screening Study: randomised screening trial. BMJ. 2014;348:g366.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    USPSTF. Screening for breast cancer: US Preventive Services Task Force recommendation statement. Ann Intern Med. 2009;151(10):716–26.CrossRefGoogle Scholar
  3. 3.
    USPSTF. Screening for breast cancer: topic page. 2013.Google Scholar
  4. 4.
    American Cancer Society. Detailed guide: breast cancer. 2012.Google Scholar
  5. 5.
    Bevers T, Anderson B, Bonaccio E, Buys S, Daly M, Dempsey P, et al. NCCN clinical practice guidelines in oncology: breast cancer screening and diagnosis. Journal of National Comprehensive Cancer Network. 2009;7:1060–96.Google Scholar
  6. 6.
    Nelson H, Tyne N, Naik A, Bougatsos C, Chan B, Humphrey L. Screening for breast cancer: systematic evidence review update for the US Preventive Services. Rockville: Agency for Healthcare Research and Quality; 2009.Google Scholar
  7. 7.
    Gotzche P, Jorgensen K. Screening for breast cancer with mammography. Cochrane Database Systematic Reviews. 2013:CD001877.Google Scholar
  8. 8.
    Brewer N, Salz T, Lillie S. Systematic Review: the long-term effects of false-positive mammograms. Annals of Internal Medicine. 2007;146(7):502–10. doi: 10.7326/0003-4819-146-7-200704030-00006.CrossRefPubMedGoogle Scholar
  9. 9.
    Lafata J, Simpkins J, Lamerato L, Poisson L, Divine G, Johnson C. The economic impact of false-positive cancer screens. Cancer Epidemiology Biomarkers and Prevention. 2004;13:2126–32.Google Scholar
  10. 10.
    Lidbrink E, Elvng J, Frisell J, Jonsson E. Neglected aspects of false positive findings of mammography in breast cancer screening: analysis of false positive cases from the Stockholm Trial. British Medical Journal. 1996;312:273–6.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Brett J, Bankhead C, Henderson B, Watson E, Austoker J. The psychological impact of mammographic screening: A systematic review. Psycho-Oncology. 2005;14:917–38.CrossRefPubMedGoogle Scholar
  12. 12.
    Bond M, Pavey K, Welch C, Cooper R, Garside S, Dean S, et al. Systematic review of the psychologic consequences of false-positive screening mammograms. Health Technology Assessment. 2013;17:1–6.CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Brodersen J, Volkert D. Long-term psychosocial consequences of false-positive screening mammography. Annals of Family Medicine. 2013;11:106–15.CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Christiansen C, Wang F, Barton M, Krueuter W, Elmore J, Gelfand A, et al. Predicting the cumulative risk of false-positive mammograms. Journal of National Cancer Institute. 2000;92:1657–66.CrossRefGoogle Scholar
  15. 15.
    Hubbard R, Kerlikowske K, Flowers C, Yankaskas B, ZHu W, Miglioretti D. Cumulative probability of false-positive recall or biopsy recommendation after 10 years of screening mammography: a cohort study. Annals of Internal Medicine. 2011;155:481–92.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Salz T, Richman A, Brewer N. Meta-analyses of the effects of false-positive mammograms on generic and specific psychosocial outcomes. Psycho-Oncology. 2010;19:1026–34.CrossRefPubMedGoogle Scholar
  17. 17.
    Jatoi I, Zhu K, Shah M, Lawrence W. Psychological distress in US women who have experienced false-positive mammograms. Breast Cancer Research and Treatment. 2006;100:191–200.CrossRefPubMedGoogle Scholar
  18. 18.
    Hafslund B, Espehaug B, Nortvedt M. Effects of false-positive results in a breast screening program on anxiety, depression, and health-related quality of life. Cancer Nursing. 2012;35:E26–35.CrossRefPubMedGoogle Scholar
  19. 19.
    Aro A, Absetz S, van Elderen T, van der Ploeg E, van der Kamp L. False-positive findings in mammography screening induces short-term distress—breast cancer-specific concern prevails longer. European Journal of Cancer. 2000;36:1089–97.CrossRefPubMedGoogle Scholar
  20. 20.
    Thomson M, Siminoff L. Perspectives on mammography after receipt of secondary screening owing to a false positive. Women’s Health Issues. 2015;25:128–33.CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Salz T, DeFrank J, Brewer N. False positive mammograms in Europe: do they affect reattendance? Breast Cancer Research and Treatment. 2011;127:229–31.CrossRefPubMedGoogle Scholar
  22. 22.
    DeFrank J, Rimer B, Bowling J, Earp J, Breslau E, Brewer N. Influence of false-positive mammography results on subsequent screening: do physician recommendations buffer negative effects? Journal of Medical Screening. 2012;19:35–41.CrossRefPubMedGoogle Scholar
  23. 23.
    Tosteson A, Fryback D, Hammond C, Hanna L, Grove M, Brown M, et al. Consequences of false-positive screening mammograms. JAMA Internal Medicine. 2014;174:954–61.CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Chamot E, Charvet A, Perneger T. Overuse of mammography during the first round of an organized breast cancer screening programme. Journal of Evaluation in Clinical Practice. 2009;15:620–5.CrossRefPubMedGoogle Scholar
  25. 25.
    Bickell NA, Wang JJ, Oluwole S, Schrag D, Godfrey H, Hiotis K, et al. Missed opportunities: racial disparities in adjuvant breast cancer treatment. Journal of Clinical Oncology. 2006;24(9):1357–62. doi: 10.1200/jco.2005.04.5799.CrossRefPubMedGoogle Scholar
  26. 26.
    Fedewa SA, Ward EM, Stewart AK, Edge SB. Delays in adjuvant chemotherapy treatment among patients with breast cancer are more likely in African American and Hispanic populations: a national cohort study 2004-2006. Journal of Clinical Oncology. 2010;28(27):4135–41. doi: 10.1200/jco.2009.27.2427.CrossRefPubMedGoogle Scholar
  27. 27.
    Ashing-Giwa K, Padilla G, Bohorquez D, Tejero J, Garcia M. Understanding the breast cancer experience of Latina women. Journal of Psychosocial Oncology. 2006;24(3):19–52. doi: 10.1300/J077v24n03_02.CrossRefPubMedGoogle Scholar
  28. 28.
    Janz N, Mujahid M, Hawley S, Griggs J, Alderman A, Hamilton A, et al. Racial/ethnic differences in quality of life after diagnosis of breast cancer. J Cancer Surviv. 2009;3:212–22.CrossRefPubMedGoogle Scholar
  29. 29.
    Molina Y, Beresford S, Espinoza N, Thompson B. Psychological distress, social withdrawal, and coping following receipt of an abnormal mammogram among Latina and non-Latina White women: a mediation model. Oncology Fursing Forum. 2014;41:523–32.CrossRefGoogle Scholar
  30. 30.
    Molina Y, Beresford S, Hayes Constant T, Thompson B. Conversations about abnormal mammogram results on distress and timely follow-up across ethnicity. Journal of Cancer Education. Published online.Google Scholar
  31. 31.
    Alegria M, Cnino G, Shrout P, Woo M, Duan N, Villa D, et al. Prevalence of mental illness in immigrant nad non-immigrant US Latino groups. American Journal of Psychiatry. 2008;165:359–69.CrossRefPubMedPubMedCentralGoogle Scholar
  32. 32.
    Yanez B, Thompson E, Stanton A. Quality of life among Latina breast cancer patients: a systematic review of the literature. J Cancer Surviv. 2011;5:191–207.CrossRefPubMedPubMedCentralGoogle Scholar
  33. 33.
    Taplin SH, Yabroff KR, Zapka J. A multilevel research perspective on cancer care delivery: the example of follow-up to an abnormal mammogram. Cancer Epidemiology, Biomarkers and Prevention. 2012;21(10):1709–15. doi: 10.1158/1055-9965.epi-12-0265.CrossRefPubMedPubMedCentralGoogle Scholar
  34. 34.
    Zapka J, Taplin S, Price R, Cranos C, Yabroff R. Factors in quality care—the case of follow-up to abnormal cancer screening tests—problems in the steps and interfaces of care. J Natl Cancer Inst Monogr. 2010;2010(40):58–71. doi: 10.1093/jncimonographs/lgq009.CrossRefPubMedPubMedCentralGoogle Scholar
  35. 35.
    Warnecke R, Oh A, Breen N, Gehlert S, Paskett E, Tucker K, et al. Approaching health disparities from a population perspective: the National Institutes of Health Centers for Population Health and Health Disparities. American Journal of Public Heath. 2008;98:1608–15.CrossRefGoogle Scholar
  36. 36.
    Austin LT, Ahmad F, McNally M-J, Stewart DE. Breast and cervical screening in Hispanic women: a literature review using the Health Belief Model. Women’s Health Issues. 2002;12:122–9.CrossRefPubMedGoogle Scholar
  37. 37.
    Molina Y, Hohl S, Ko L, Rodriguez E, Thompson B, Beresford S. Understanding the patient-provider communication needs of Latina and non-Latina White women following an abnormal mammogram. Journal of Cancer Education. 2014;29:781–9.CrossRefPubMedPubMedCentralGoogle Scholar
  38. 38.
    Karliner L, Kaplan C, Juarbe T, Pasick R, Pérez-Stable E. Poor patient comprehension of abnormal mammography results. Journal of General Internal Medicine. 2005;20(5):432–7. doi: 10.1111/j.1525-1497.2005.40281.x.CrossRefPubMedPubMedCentralGoogle Scholar
  39. 39.
    Moy B, Park ER, Feibelmann S, Chaing S, Weissman JS. Barriers to repeat mammography: cultural perspectives of African-American, Asian, and Hispanic women. Psycho-Oncology. 2006;15:623–34.CrossRefPubMedGoogle Scholar
  40. 40.
    Shelton R, Goldman R, Emmons K, Sorenson G, Allen J. An investigation into the social context of low-income, urban Black and Latina women: implications for adherence to recommended health behaviors. Health Education Behavior. 2011;38:471–81.CrossRefPubMedGoogle Scholar
  41. 41.
    De Los MK, Gallo L The relevance of fatalism in the study of Latinas’ cancer screening behavior: a systematic review of the literature. International Journal of Behavioral Medicine. 2011;18:310–8.CrossRefGoogle Scholar
  42. 42.
    Espinosa de los Monteros K, Gallo L. The relevance of fatalism in the study of Latinas’ cancer screening behavior: a systematic review of the literature. International Journal of Behavioral Medicine. 2011;18:310–8.CrossRefPubMedGoogle Scholar
  43. 43.
    Heckman B, Fisher E, Monsees B, Merbaum M, Ristvedt S, Bishop C. Coping and anxiety in women recalled for additional diagnostic procedures following an abnormal screening mammogram. Health Psychol. 2004;23(1):42–8. doi: 10.1037/0278-6133.23.1.42.CrossRefPubMedGoogle Scholar
  44. 44.
    Culver J, Arena P, Antoni M, Carver C. Coping and distress among women under treatment for early stage breast cancer: comparing African Americans, Hispanics and non-Hispanic Whites. Psycho-Oncology. 2002;11(6):495–504. doi: 10.1002/pon.615.CrossRefPubMedGoogle Scholar
  45. 45.
    Carver CS, Smith R, Petronis V, Antoni M. Quality of life among long-term survivors of breast cancer: different types of antecedents predict different classes of outcomes. Psycho-Oncology. 2006;15:749–58.CrossRefPubMedGoogle Scholar
  46. 46.
    Cockburn J, De Luise T, Hurley S, Clover K. Development and validation of the PCQ: a questionnaire to measure the psychological consequences of screening mammography. Soc Sci Med.1992;34(10):1129–34.CrossRefPubMedGoogle Scholar
  47. 47.
    Ashing-Giwa K, Gonzalez P, Lim J-W, Chung C, Paz B, Somlo G, et al. Diagnostic and therapeutic delays among a multiethnic sample of breast and cervical cancer survivors. Cancer. 2010;116:3195–204.CrossRefPubMedGoogle Scholar
  48. 48.
    Ramirez A, Pérez-Stable E, Penedo F, Talavera G, Carrillo J, Fernandez M, et al. Navigating Latinas with breast screen abnormalities to diagnosis. Cancer. 2013;119(7):1298–305. doi: 10.1002/cncr.27912.CrossRefPubMedGoogle Scholar
  49. 49.
    Chavez LR, Hubbell FA, McMullen JM, Martinez RG, Mishra SI. Structure and meaning in models of breast and cervical cancer risk factors: a comparison of perceptions among Latinas, Anglo women, and physicians. Medical Anthropology Quarterly. 2009;9:40–74.CrossRefGoogle Scholar
  50. 50.
    Ramirez AG, Suarez L, Laufman L, Barroso C, Chalela P. Hispanic women’s breast and cervical knowledge, attitudes, and screening behaviors. American Journal of Health Promotion. 2000;14:292–300.CrossRefPubMedGoogle Scholar
  51. 51.
    Schettino MR, Hernandez-Valero MA, Moguel R, Hajek RA, Jones LA. Assessing breast cancer knowledge, beliefs and misconceptions among Latinas in Houston. Texas Journal of Cancer Education. 2006;21:S42–S6.CrossRefPubMedGoogle Scholar
  52. 52.
    Niederdeppe J, Levy AG. Fatalistic beliefs about cancer prevention and three prevention behaviors. Cancer Epidemiology Biomarkers and Prevention. 2007;16:998–1003.CrossRefGoogle Scholar
  53. 53.
    Tavakol M, Dennick R. Making sense of Cronbach’s alpha. International Journal of Medical Education. 2011;2:53–5.CrossRefPubMedPubMedCentralGoogle Scholar
  54. 54.
    Nunnally J Psychometric theory. New York: McGraw-Hill; 1978.Google Scholar
  55. 55.
    Katapodi MC, Lee KA, Facione NC, Dodd MJ. Predictors of perceived breast cancer risk and the relation between perceived risk and breast cancer screening: a meta-analytic review. Prev Med. 2004;38:388–402.CrossRefPubMedGoogle Scholar
  56. 56.
    Lipkus I, Halabi S, Strigo T, Rimer B. The impact of abnormal mammograms on psychosocial outcomes and subsequent screening. Psycho-Oncology. 2000;9:402–10.CrossRefPubMedGoogle Scholar
  57. 57.
    McGregor B, Bowen D, Ankerst D, Andersen M, Yasui M, McTiernan A. Optimism, perceived risk of breast cancer, and cancer worry among a community-based sample of women. Health Psychology. 2004;23:339–44.CrossRefPubMedGoogle Scholar
  58. 58.
    Pineault P Breast cancer screening: Women’s experiences of waiting for further testing. Oncology Nursing Forum. 2007;34:847–54.CrossRefPubMedGoogle Scholar
  59. 59.
    Bowland L, Cockburn J, Cawson J, Anderson H, Moorehead S, Kenny M. Counselling interventions to address the psychological consequences of screening mammography: a randomised trial. Patient Educ Couns. 2003;49(2):189–98.CrossRefPubMedGoogle Scholar
  60. 60.
    Marin G, Marin BV. Research with Hispanic populations. CA: Sage Publications Newbury Park; 1991.CrossRefGoogle Scholar
  61. 61.
    Allen J, Shelton R, Harden E, Goldman R. Follow-up of abnormal screening mammograms among low-income ethnically diverse women: findings from a qualitative study. Patient Education and Counseling. 2008;72:283–92.CrossRefPubMedGoogle Scholar
  62. 62.
    Mojica C, Bastani R. Receipt of diagnostic tests for breast cancer: validity of self-reports among low-income, mostly Latina, indigent women. Evaluation and Health Profession. 2010;33:437–51.CrossRefGoogle Scholar
  63. 63.
    Mojica C, Bastani R, Ponce N, Boscardin W. Latinas with abnormal breast findings: patient predictors of timely diagnostic resolution. Journal of Women’s Health. 2007;16:1468–78.CrossRefPubMedGoogle Scholar
  64. 64.
    Ooi SL, Martinez ME, Li CI. Disparities in breast cancer characteristics and outcomes by race/ethnicity. Breast Cancer Research and Treatment. 2011;127:729–38.CrossRefPubMedGoogle Scholar

Copyright information

© W. Montague Cobb-NMA Health Institute 2016

Authors and Affiliations

  • Yamile Molina
    • 1
    • 3
  • Shirley A. A. Beresford
    • 2
    • 3
  • Beti Thompson
    • 2
    • 3
  1. 1.School of Public HealthUniversity of Illinois-ChicagoChicagoUSA
  2. 2.School of Public HealthUniversity of WashingtonSeattleUSA
  3. 3.Cancer Prevention ProgramFred Hutchinson Cancer Research CenterSeattleUSA

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