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Liver and Other Gastrointestinal Cancers Are Frequent in Mexican Americans

  • Ariana L. Garza
  • Kristina P. Vatcheva
  • Jen-Jung Pan
  • Mohammad H. Rahbar
  • Michael B. Fallon
  • Joseph B. McCormick
  • Susan P. Fisher-HochEmail author
Article

Abstract

Background

Disease patterns in Mexican American health-disparity populations differ from larger US populations.

Aims

This study is aimed to determine frequency of gastrointestinal cancers in Mexican Americans.

Methods

We analyzed self-reported data from the Cameron County Hispanic Cohort where we find high rates of risk factors for cancer: obesity (48.5 %) and diabetes (30.7 %). Participants provided cancer histories about themselves and first- and second-degree relatives. Logistic regression models assessed risk factors. Frequencies of cancer sites were ranked and validated using concurrent age local cancer registry data.

Results

Among 9,249 individuals (participants and their relatives), there were 1,184 individuals with reports of cancer. Among cohort participants under 70 years of age, the most significant risk factor for all-cause cancers was diabetes (OR 3.57, 95 % CI 1.32, 9.62). Participants with metabolic syndrome were significantly more likely to report cancer in relatives [1.73 (95 % CI 1.26, 2.37]. Among cancers in fathers, liver cancer was ranked third, stomach fourth, colorectal sixth, and pancreas tenth. In mothers, stomach was third, liver fourth, colorectal seventh, and pancreas eleventh. The unusual prominence of these cancers in Mexican Americans, including liver cancer, was supported by age-adjusted incidence in local registry data.

Conclusions

Gastrointestinal system cancers, particularly, liver cancer, in a Mexican American health disparity cohort and their relatives rank higher than in other ethnicities and are associated with high rates of diabetes and metabolic syndrome. Effective prevention of diabetes and low-tech, high-quality screening strategies for gastrointestinal cancers are needed in health disparity communities.

Keywords

Gastrointestinal cancer Liver Diabetes Mexican Americans 

Notes

Acknowledgments

We thank Dr. Brian Smith, Director of Region 11, Texas Department of State Health Services, for reviewing the manuscripts and helpful suggestions. We thank our cohort recruitment team, particularly, Rocio Uribe and Julie Ramirez-Gomez. We also thank Marcela Montemayor and other laboratory staff for their contribution, Gloria Sanchez and Pablo Sanchez for our database management, and Christina Villarreal for administrative support. We thank Valley Baptist Medical Center, Brownsville, for providing us space for our Center for Clinical and Translational Science Clinical Research Unit. We finally thank the community of Brownsville and the participants who so willingly participated in this study in their city.

Compliance with Ethical Standards

Ms. Garza and Ms. Vatcheva declare that they have no conflict of interest. Drs. Fisher-Hoch, Rahbar, Fallon, Pan, and McCormick declare they have no conflict of interest.

Informed Consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000 [5]. Informed consent was obtained from all patients for being included in the study. No identifying information was used in this article. This study and all procedures including written informed consent forms were approved by the Committee for the Protection of Human Subjects at University of Texas Health (UTHealth), Houston (approval numbers HSC-SPH-03-007 A and B). The study was explained to all participants in their language of choice (Spanish or English) before obtaining written consent.

No animals were used in this study.

Grant Support

This work was supported by MD000170 P20 funded from the National Institute on Minority Health and Health Disparities (NIMHD), and the Centers for Clinical and Translational Science Award 1U54RR023417-01 from the National Center for Research Resources (NCRR).

Funding Sources

This work was supported by MD000170 P20 funded from the National Center on Minority Health and Health disparities (NCMHD), and the Centers for Clinical and Translational Science Award UL1 TR000371 from the National Center for Research Resources (NCRR).

Conflict of Interest

None of the authors have any relationships that they believe could be construed as resulting in an actual, potential, or perceived conflict of interest with regard to this manuscript submitted for review.

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Copyright information

© W. Montague Cobb-NMA Health Institute 2015

Authors and Affiliations

  • Ariana L. Garza
    • 1
  • Kristina P. Vatcheva
    • 1
  • Jen-Jung Pan
    • 2
  • Mohammad H. Rahbar
    • 3
  • Michael B. Fallon
    • 2
  • Joseph B. McCormick
    • 1
  • Susan P. Fisher-Hoch
    • 1
    Email author
  1. 1.Division of Epidemiology, Human Genetics and Environmental ScienceUniversity of Texas Health Science Center at Houston School of Public HealthBrownsvilleUSA
  2. 2.Division of Gastroenterology, Hepatology and Nutrition, Department of Internal MedicineUniversity of Texas Health Science Center at HoustonHoustonUSA
  3. 3.Division of Epidemiology, Human Genetics and Environmental Sciences, and Center for Clinical and Translational Sciences, Medical SchoolUniversity of Texas Health Science Center at Houston School of Public HealthHoustonUSA

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