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The Impact of Early-Life Exposure to Antimicrobials on Asthma and Eczema Risk in Children

  • Medina S. Jackson-BrowneEmail author
  • Noelle Henderson
  • Marisa Patti
  • Adam Spanier
  • Joseph M. Braun
Synthetic Chemicals and Health (A Zota and T James-Todd, Section Editors)
  • 36 Downloads
Part of the following topical collections:
  1. Topical Collection on Synthetic Chemicals and Health

Abstract

Purpose of Review

We examined recent research on associations of prenatal and early-childhood exposure to the antimicrobial compounds, triclosan, and parabens, with the risk of asthma and eczema in children. We will discuss potential biological mechanisms of this association and highlight strengths and limitations of the study design and exposure assessment of current findings.

Recent Findings

Results of available toxicological and epidemiologic studies indicate a potential link of triclosan and paraben exposures with asthma and eczema in children, as well as changes in microbiome diversity and immune dysfunction, which could possibly mediate an association with the health outcomes.

Summary

A small number of studies suggest that triclosan and paraben exposures could be related to the risk of asthma and eczema in children. Although current findings are far from conclusive, there is emerging evidence that changes in microbiome diversity and immune function from antimicrobial exposure may mediate these relations.

Keywords

Triclosan Parabens Children’s health Eczema Asthma Immune system 

Notes

Compliance with Ethical Standards

Conflict of Interest

Dr. Braun reports personal fees from Beveridge-Diamond outside of the submitted work. The other authors declare no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Medina S. Jackson-Browne
    • 1
    Email author
  • Noelle Henderson
    • 2
  • Marisa Patti
    • 2
  • Adam Spanier
    • 3
  • Joseph M. Braun
    • 2
  1. 1.Epidemiology Program, College of Health SciencesUniversity of DelawareNewarkUSA
  2. 2.Department of EpidemiologyBrown UniversityProvidenceUSA
  3. 3.Department of Pediatrics, Division of General PediatricsUniversity of Maryland School of MedicineBaltimoreUSA

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