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Current Environmental Health Reports

, Volume 5, Issue 4, pp 522–530 | Cite as

Pesticides and Child’s Health in France

  • Cécile ChevrierEmail author
  • Rémi Béranger
Early Life Environmental Health (J Sunyer and P Dadvand, Section Editors)
  • 60 Downloads
Part of the following topical collections:
  1. Topical Collection on Early Life Environmental Health

Abstract

Purpose of Review

The use of pesticides is predominant in agriculture, inducing environmental contamination, and has been extended to the domestic sphere. In France, > 500 pesticides were authorized for use in 2009; given their various toxicological properties, there are legitimate concerns about the possible consequences for child health. This review summarizes the recent French studies of good quality dealing with pesticides and child health.

Recent Findings

Three cohorts (mother–child, retrospective) and two case–control studies have been conducted in the last decade. Using various instruments for exposure assessment including biomarkers, they have suggested alterations of subclinical health parameters at birth, increased risk of otitis at age 2, and increased risk of several types of childhood cancer. However, there were no adverse neurodevelopmental outcomes at 6 years of age following prenatal exposure to pesticides.

Summary

Both agricultural and domestic pesticides might be involved in such adverse health outcomes. Similar studies are lacking in Europe. Studies on fungicides and child health are scarce.

Keywords

Pesticides Environmental exposure Pregnancy Growth Neurodevelopment Cancer 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. 1.
    European Commission. 2017. EU Pesticides database. Available: http://ec.europa.eu/food/plant/pesticides_en. Last visit: March 28th, 2017.
  2. 2.
    •• ANSES, Exposition de la population générale aux résidus de pesticides en France : Synthèse et recommandations du comité d'orientation et de prospective scientifique de l'observatoire des résidus de pesticides, ORP. Rapport scientifique, 2010. https://www.anses.fr/fr/content/exposition-de-la-population-g%C3%A9n%C3%A9rale-aux-pesticides. This report is the first in France to provide a thorough overview of the existing data describing the exposure to current-used pesticides of the general population, from the possible exposure sources including environmental contamination data to the human biomonitoring data.
  3. 3.
    Cordier S, Bouquet E, Warembourg C, Massart C, Rouget F, Kadhel P, et al. Perinatal exposure to chlordecone, thyroid hormone status and neurodevelopment in infants: the Timoun cohort study in Guadeloupe (French West Indies). Environ Res. 2015;138:271–8.CrossRefGoogle Scholar
  4. 4.
    Costet N, Pelé F, Comets E, Rouget F, Monfort C, Bodeau-Livinec F, et al. Perinatal exposure to chlordecone and infant growth. Environ Res. 2015;142:123–34.CrossRefGoogle Scholar
  5. 5.
    Hervé D, Costet N, Kadhel P, Rouget F, Monfort C, Thomé JP, et al. Prenatal exposure to chlordecone, gestational weight gain, and birth weight in a Guadeloupean birth cohort. Environ Res. 2016;151:436–44.CrossRefGoogle Scholar
  6. 6.
    Aubertot JN, Barbier JM, Carpentier A, Gril JJ, Guichard L, Lucas P et al. Pesticides, agriculture et environnement. Réduire l'utilisation des pesticides et limiter leurs impacts environnementaux. Expertise scientifique collective, synthèse du rapport, INRA et Cemagref (France), 64 p, 2005. http://institut.inra.fr/Missions/Eclairer-les-decisions/Expertises/Toutes-les-actualites/Pesticides-agriculture-etenvironnement.
  7. 7.
    CGDD, Commissariat général au Développement durable. Service de l’observation et des statistiques. Ministère de la Transition écologique et Solidaire. Indicateurs de la transition écologique vers un développement durable – Comparaisons internationales. Mai 2017 (http://www.statistiques.developpement-durable.gouv.fr/fileadmin/documents/Produits_editoriaux/Publications/Datalab/2017/Datalab-19-INTEDD-comparaisons-internationales-mai-2017.pdf).
  8. 8.
    CGDD, Commissariat général au Développement durable. Service de l’observation et des statistiques. Ministère de la Transition écologique et Solidaire. Les pesticides dans les cours d’eau français en 2013. Chiffres & statistiques n° 697 - novembre 2015 (http://www.statistiques.developpement-durable.gouv.fr/fileadmin/documents/Produits_editoriaux/Publications/Chiffres_et_statistiques/2015/chiffres-stats697-pesticides-dans-cours-deau2013-novembre2015.pdf).
  9. 9.
    Nougadère A, Sirot V, Kadar A, Fastier A, Truchot E, Vergnet C, et al. Total diet study on pesticide residues in France: levels in food as consumed and chronic dietary risk to consumers. Environ Int. 2012;45:135–50.CrossRefGoogle Scholar
  10. 10.
    Bouvier G, Blanchard O, Momas I, Seta N. Environmental and biological monitoring of exposure to organophosphorus pesticides: application to occupationally and non-occupationally exposed adult populations. J Expo Sci Environ Epidemiol. 2006;16(5):417–26.CrossRefGoogle Scholar
  11. 11.
    Chevrier C, Petit C, Limon G, Monfort C, Durand G, Cordier S. Biomarqueurs urinaires d’exposition aux pesticides des femmes enceintes de la cohorte Pélagie réalisée en Bretagne (2002-2006). Bulletin Epidémiologique Hebdomadaire. Edition spéciale. 2009. http://opac.invs.sante.fr/doc_num.php?explnum_id=893.
  12. 12.
    Fréry N, Saoudi A, Garnier R, Zeghnoun A, Falq G, Guldner L. Exposition de la population française aux polluants de l’environnement – Volet environnemental de l’Étude nationale nutrition santé – Premiers résultats. Institut de veille sanitaire: Saint-Maurice; 2010. 12 pGoogle Scholar
  13. 13.
    Dereumeaux C, Saoudi A, Pecheux M, Berat B, de Crouy-Chanel P, Zaros C, et al. Biomarkers of exposure to environmental contaminants in French pregnant women from the Elfe cohort in 2011. Environ Int. 2016;97:56–67.CrossRefGoogle Scholar
  14. 14.
    Petit C, Blangiardo M, Richardson S, Coquet F, Chevrier C, Cordier S. Association of environmental insecticide exposure and fetal growth with a Bayesian model including multiple exposure sources: the PELAGIE mother-child cohort. Am J Epidemiol. 2012;175(11):1182–90.CrossRefGoogle Scholar
  15. 15.
    Buscail C, Chevrier C, Serrano T, Pelé F, Monfort C, Cordier S, et al. Prenatal pesticide exposure and otitis media during early childhood in the PELAGIE mother-child cohort. Occup Environ Med. 2015;72(12):837–44.CrossRefGoogle Scholar
  16. 16.
    • Chevrier C, Limon G, Monfort C, Rouget F, Garlantézec R, Petit C, et al. Urinary biomarkers of prenatal atrazine exposure and adverse birth outcomes in the PELAGIE birth cohort. Environ Health Perspect. 2011;119(7):1034–41 This study evaluates for the first time with exposure biomarkers the association between atrazine exposure and child health; it has suggested possible adverse impact on fetal growth, especially on head circumference. CrossRefGoogle Scholar
  17. 17.
    Viel JF, Warembourg C, Le Maner-Idrissi G, Lacroix A, Limon G, Rouget F, et al. Pyrethroid insecticide exposure and cognitive developmental disabilities in children: the PELAGIE mother-child cohort. Environ Int. 2015;82:69–75.CrossRefGoogle Scholar
  18. 18.
    Viel JF, Rouget F, Warembourg C, Monfort C, Limon G, Cordier S, et al. Behavioural disorders in 6-year-old children and pyrethroid insecticide exposure: the PELAGIE mother-child cohort. Occup Environ Med. 2017;74(4):275–81.CrossRefGoogle Scholar
  19. 19.
    Cartier C, Warembourg C, Le Maner-Idrissi G, Lacroix A, Rouget F, Monfort C, et al. Organophosphate insecticide metabolites in prenatal and childhood urine samples and intelligence scores at 6 years of age: results from the mother-child PELAGIE cohort (France). Environ Health Perspect. 2016;124(5):674–80.CrossRefGoogle Scholar
  20. 20.
    Debost-Legrand A, Warembourg C, Massart C, Chevrier C, Bonvallot N, Monfort C, et al. Prenatal exposure to persistent organic pollutants and organophosphate pesticides, and markers of glucose metabolism at birth. Environ Res. 2016;146:207–17.CrossRefGoogle Scholar
  21. 21.
    Mayhoub F, Berton T, Bach V, Tack K, Deguines C, Floch-Barneaud A, et al. Self-reported parental exposure to pesticide during pregnancy and birth outcomes: the MecoExpo cohort study. PLoS One. 2014;9(6):e99090.CrossRefGoogle Scholar
  22. 22.
    Migeot V, Albouy-Llaty M, Carles C, Limousi F, Strezlec S, Dupuis A, et al. Drinking-water exposure to a mixture of nitrate and low-dose atrazine metabolites and small-for-gestational age (SGA) babies: a historic cohort study. Environ Res. 2013;122:58–64.CrossRefGoogle Scholar
  23. 23.
    Albouy-Llaty M, Limousi F, Carles C, Dupuis A, Rabouan S, Migeot V. Association between exposure to endocrine disruptors in drinking water and preterm birth, taking neighborhood deprivation into account: a historic cohort study. Int J Environ Res Public Health 2016;13(8).Google Scholar
  24. 24.
    Tourneux P, Mayhoub F, Haraux E, Deguines C, Berton T, Lestremeau F, et al. MecoExpo cohort: using meconium to estimate in utero exposure to pesticides in newborn infants in Picardy. Rev Méd Périnat. 2014;6:122–33. https://link.springer.com/article/10.1007%2Fs12611-014-0277-5.
  25. 25.
    Clavel J, Goubin A, Auclerc MF, Auvrignon A, Waterkeyn C, Patte C, et al. Incidence of childhood leukaemia and non-Hodgkin’s lymphoma in France: National Registry of Childhood Leukaemia and Lymphoma, 1990–1999. Eur J Cancer Prev. 2004;13:97–103.Google Scholar
  26. 26.
    Bailey HD, Fritschi L, Infante-Rivard C, Glass DC, Miligi L, Dockerty JD, et al. Parental occupational pesticide exposure and the risk of childhood leukemia in the offspring: findings from the childhood leukemia international consortium. Int J Cancer. 2014;135(9):2157–72.CrossRefGoogle Scholar
  27. 27.
    Rios P, Bailey HD, Lacour B, Valteau-Couanet D, Michon J, Bergeron C, et al. Maternal use of household pesticides during pregnancy and risk of neuroblastoma in offspring. A pooled analysis of the ESTELLE and ESCALE French studies (SFCE). Cancer Causes Control. 2017;28(10):1125–32.CrossRefGoogle Scholar
  28. 28.
    • Bailey HD, Infante-Rivard C, Metayer C, Clavel J, Lightfoot T, Kaatsch P, et al. Home pesticide exposures and risk of childhood leukemia: Findings from the childhood leukemia international consortium. Int J Cancer. 2015;137(11):2644–63 This study is the fruit of international collaborative efforts and has allowed to replicate previous results of individual studies. It shows that this collaborative effort should be maintained and improved for better exposure assessment across involved studies. CrossRefGoogle Scholar
  29. 29.
    Vidart D’Egurbide Bagazgoïtia N, Bailey HD, Orsi L, Lacour B, Guerrini-Rousseau L, Bertozzi AI, et al. Maternal residential pesticide use during pregnancy and risk of malignant childhood brain tumors: a pooled analysis of the ESCALE and ESTELLE studies (SFCE). Int J Cancer. 2018;142(3):489–97.CrossRefGoogle Scholar
  30. 30.
    Berton T, Mayhoub F, Chardon K, Duca RC, Lestremau F, Bach V, et al. Development of an analytical strategy based on LC-MS/MS for the measurement of different classes of pesticides and theirs metabolites in meconium: application and characterisation of foetal exposure in France. Environ Res. 2014 Jul;132:311–20.CrossRefGoogle Scholar
  31. 31.
    Slusky DA, Metayer C, Aldrich MC, Ward MH, Lea CS, Selvin S, et al. Reliability of maternal-reports regarding the use of household pesticides: experience from a case–control study of childhood leukemia. Cancer Epidemiol. 2012;36:375–80.CrossRefGoogle Scholar
  32. 32.
    Deziel NC, Colt JS, Kent EE, Gunier RB, Reynolds P, Booth B, et al. Associations between self-reported pest treatments and pesticide concentrations in carpet dust. Environ Health. 2015;14:27.CrossRefGoogle Scholar
  33. 33.
    Trunnelle KJ, Bennett DH, Tancredi DJ, Gee SJ, Stoecklin-Marois MT, Hennessy-Burt TE, et al. Pyrethroids in house dust from the homes of farm worker families in the MICASA study. Environ Int. 2013;61:57–63.CrossRefGoogle Scholar
  34. 34.
    Glorennec P, Serrano T, Fravallo M, Warembourg C, Monfort C, Cordier S, et al. Determinants of children’s exposure to pyrethroid insecticides in western France. Environ Int. 2017 Jul;104:76–82.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  1. 1.Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085RennesFrance

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