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Current Environmental Health Reports

, Volume 4, Issue 1, pp 30–37 | Cite as

Extracellular Vesicles: How the External and Internal Environment Can Shape Cell-To-Cell Communication

  • Kristof Y. Neven
  • Tim S. Nawrot
  • Valentina BollatiEmail author
Environment and Aging (A Peters, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Environment and Aging

Abstract

Purpose of the review

To summarize the scientific evidence regarding the effects of environmental exposures on extracellular vesicle (EV) release and their contents. As environmental exposures might influence the aging phenotype in a very strict way, we will also report the role of EVs in the biological aging process.

Recent findings

EV research is a new and quickly developing field. With many investigations conducted so far, only a limited number of studies have explored the potential role EVs play in the response and adaptation to environmental stimuli. The investigations available to date have identified several exposures or lifestyle factors able to modify EV trafficking including air pollutants, cigarette smoke, alcohol, obesity, nutrition, physical exercise, and oxidative stress.

Summary

EVs are a very promising tool, as biological fluids are easily obtainable biological media that, if successful in identifying early alterations induced by the environment and predictive of disease, would be amenable to use for potential future preventive and diagnostic applications.

Keywords

Extracellular vesicles Exosomes Microvesicles Environmental exposures Aging 

Notes

Acknowledgements

V.B. and T.S.N. received support from the European Union Programme “Ideas” (ERC-2011-StG 282413 and ERC-2012-StG 310898).

Compliance with Ethical Standards

Conflict of Interest

Kristof Y. Neven, Tim S. Nawrot, and Valentina Bollati declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Supplementary material

40572_2017_130_MOESM1_ESM.docx (36 kb)
Appendix 1 (DOCX 35 kb)

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Kristof Y. Neven
    • 1
  • Tim S. Nawrot
    • 1
  • Valentina Bollati
    • 2
    Email author
  1. 1.Centre for Environmental SciencesHasselt UniversityDiepenbeekBelgium
  2. 2.EPIGET – Epidemiology, Epigenetics and Toxicology Lab, Department of Clinical Sciences and Community HealthUniversità degli Studi di MilanoMilanItaly

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