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Current Environmental Health Reports

, Volume 3, Issue 4, pp 392–404 | Cite as

Manganese Exposure and Cognition Across the Lifespan: Contemporary Review and Argument for Biphasic Dose–Response Health Effects

  • Kaitlin Vollet
  • Erin N. Haynes
  • Kim N. Dietrich
Metals and Health (A Barchowsky, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Metals and Health

Abstract

Manganese (Mn) is both an essential micronutrient and potential neurotoxicant. This dual role underlies a growing body of literature demonstrating that Mn exhibits a biphasic dose–response relationship with neurocognitive outcomes. We reviewed recent epidemiologic studies from 2007 to 2016 that investigated the relationship between Mn exposure and cognitive outcomes across the lifespan: early life, school-aged children, and adulthood. In total, 27 research articles were included in this review: 12 pediatric and 15 adult studies (10 occupational and five environmental exposures). The majority of these studies provided evidence of the negative effects of Mn exposure on cognition. The pediatric literature provides evidence that both high and low levels of Mn are negatively associated with intellectual development. Future Mn research should include examination of non-linear relationships and multiple neurotoxicants across the lifespan and particularly during critical developmental windows.

Keywords

Pediatric Manganese Dose–response Literature review Occupational Cognition 

Abbreviations

BSID

Bayley Scales of Infant Development

CANTAB

Cambridge Neuropsychological Test Automated Battery

CAVLT

Children’s Auditory Verbal Learning Test

CCTT

Children’s Color Trails Test

CDIIT

Comprehensive Developmental Inventory for Infants and Toddlers

CFS

Cognitive Function Scanner

CPT

Continuous Performance Test

ETS

Environmental tobacco smoke

IQ

Intelligence quotient

K-AVLT

Korean Auditory Verbal Learning Test

K-CFT

Korean Complex Figure Test

LDES

Learning Disability Evaluation Scale

MDI

Mental Development Index

MMSE

Mini-Mental State Examination

MoCA

Montreal Cognitive Assessment

MR

Matrix reasoning

NAB

Neuropsychological Assessment Battery

PI

Pallidal Index

RAVLT

Rey Auditory Verbal Learning Test

RCPM

Raven’s Colored Progressive Matrix

RSPM

Raven’s Standard Progressive Matrix

TAVIS

The Brazilian Attention Test

TMT

Trailing Making Test

WAIS

Wechsler Adult Intelligence Scale

WCST

Wisconsin Card Sorting Test

WISC

Wechsler Intelligence Scale for Children

Notes

Compliance and Ethical Standards

Conflict of Interest

Kaitlin Vollet, Erin N. Haynes, and Kim N. Dietrich declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors in the conduct of this literature review.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of outstanding importance

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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  • Kaitlin Vollet
    • 1
  • Erin N. Haynes
    • 1
  • Kim N. Dietrich
    • 1
  1. 1.Division of Epidemiology, Department of Environmental Health, College of MedicineUniversity of CincinnatiCincinnatiUSA

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