Journal of Fetal Medicine

, Volume 6, Issue 3, pp 123–126 | Cite as

Women with Positive First Trimester Thyroid Disease Screening Results

  • Ishraq DhaifalahEmail author
  • Jana Havalova
  • Dagmar Langova
  • Zdenek Adamik
  • Howard Cuckle
Original Article


The objective of this study was to follow up women with positive results on routine antenatal screening for maternal thyroid disease. Between November 2009 and September 2015, women having a first trimester Down’s syndrome screening test were simultaneously screened for thyroid disease; those symptomatic or being investigated for thyroid problems were excluded. A blood sample was tested for anti-thyroid peroxidase antibodies and serum thyroid stimulating hormone, and in the first half of the study also for free thyroxine. Women with at least one analyte outside the range were classified as positive and referred to an endocrinologist for counselling. Among 10,052 women that were screened, 1190 (11.8%) were positive. Follow-up information was sought and this was available on 818 referrals. No further action was recommended in 440 (54%) and after repeat testing in 108 (13%) a total of 204 (25%) were recommended to take thyroxine, one was referred for surgery and propylthiouracil was recommended for five. Screening in the Czech Republic identifies an estimated 3.1% of pregnant women with subclinical thyroid disease.


Thyroid disease Screening Antenatal Endocrinologist Follow-up 



We thank Mr. Dvoracek and technicians of the Clinical Biochemistry and Pharmacology Department for providing the results promptly and for being available for discussion. We thank the nursing staff of the Centre of Fetal Medicine and the Department of Endocrinology for their help in gathering outcome information. We thank all gynaecologists who referred their patients to our centre.



Compliance with Ethical Standards

Conflict of interest

HC is a consultant to PerkinElmer Inc. Other authors have no financial interests.

Ethical Statement

This is an audit of a clinical service therefore no ethical approval was required.


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Copyright information

© Society of Fetal Medicine 2019

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyRegional HospitalZlinCzech Republic
  2. 2.FETMED (Fetmed Fetal Medicine Center and Genetics)Olomouc, OstravaCzech Republic
  3. 3.Department of Biomedical Sciences, Faculty of MedicineUniversity of OstravaOstravaCzech Republic
  4. 4.Department of Internal Medicine ClinicRegional HospitalZlinCzech Republic
  5. 5.Department of Obstetrics and GynaecologyColumbia University Medical CentreNew YorkUSA

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