The aim of this study was to evaluate the effect of causes of delivery on short-term neonatal morbidities and mortality in EPD (< 34 gestational weeks). We retrospectively analysed the deliveries occurring between 23 + 0 and 33 + 6th gestational weeks at our tertiary center during 2014–2018. A total of 290 deliveries were evaluated, and 369 newborns [singletons (56.4%), twins (36.6%) and triplets (7.1%)] were included in the study. The causes of deliveries were defined as spontaneously preterm birth (n = 107, 29%), preterm premature rupture of membranes (PPROM) (n = 131, 35.5%) or iatrogenic preterm birth (n = 131, 35.5%). The rate of neonatal respiratory distress syndrome (RDS), patent ductus arteriosus, bronchopulmonary dysplasia (BPD), intraventricular haemorrhagia (IVH), necrotising enterocolitis, retinopathy of prematurity, neonatal resuscitation, sepsis and death were similar between groups. However; neonatal RDS, BPD, IVH and sepsis were found to be higher in cases with chorioamnionitis, which could be considered as subcategory of PPROM. Preterm deliveries have an adverse effect on perinatal outcomes. Also, such causes of labor might be related to varied neonatal morbidities. However, splitting to early preterm deliveries into subgroups, according to cause of delivery, did not provide further information to predict such complications except chorioamnionitis.
Premature rupture of membranes Prematurity—risk assessment and prevention Premature labor
This is a preview of subscription content, log in to check access.
This study was approved by the Baskent University Institutional Review Board (Project No. KA18/220) and supported by the Baskent University Research Fund.
This research did not receive any specific grant from funding agencies in the public commercial.
Compliance with ethical standards
Conflict of interest
We declare no competing financial interests in relation to this study.
Kenyon SL, Taylor DJ, Tarnow-Mordi W, Group OC. Broad-spectrum antibiotics for preterm, prelabour rupture of fetal membranes: the ORACLE I randomised trial. ORACLE Collaborative Group. Lancet. 2001;357(9261):979–88.CrossRefGoogle Scholar
Frusca T, Todros T, Lees C, Bilardo CM, Hecher K, Visser GHA, et al. Outcome in early-onset fetal growth restriction is best combining computerized fetal heart rate analysis with ductus venosus Doppler: insights from the Trial of Umbilical and Fetal Flow in Europe. Am J Obstet Gynecol. 2018;218(2):S783–9. https://doi.org/10.1016/j.ajog.2017.12.226.CrossRefPubMedGoogle Scholar
Lees C, Marlow N, Arabin B, Bilardo CM, Brezinka C, Derks JB, et al. Perinatal morbidity and mortality in early-onset fetal growth restriction: cohort outcomes of the trial of randomized umbilical and fetal flow in Europe (TRUFFLE). Ultrasound Obstet Gynecol. 2013;42(4):400–8. https://doi.org/10.1002/uog.13190.CrossRefPubMedGoogle Scholar
Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978;92(4):529–34.CrossRefGoogle Scholar
Walsh MC, Kliegman RM. Necrotizing enterocolitis: treatment based on staging criteria. Pediatr Clin North Am. 1986;33(1):179–201.CrossRefGoogle Scholar
Tita AT, Doherty L, Roberts JM, Myatt L, Leveno KJ, Varner MW, et al. Adverse maternal and neonatal outcomes in indicated compared with spontaneous preterm birth in healthy nulliparas: a secondary analysis of a randomized trial. Am J Perinatol. 2018;35(7):624–31. https://doi.org/10.1055/s-0037-1608787.CrossRefPubMedGoogle Scholar
Owen J, Baker SL, Hauth JC, Goldenberg RL, Davis RO, Copper RL. Is indicated or spontaneous preterm delivery more advantageous for the fetus? Am J Obstet Gynecol. 1990;163(3):868–72.CrossRefGoogle Scholar
Shah DM, Shenai JP, Vaughn WK. Neonatal outcome of premature infants of mothers with preeclampsia. J Perinatol. 1995;15(4):264–7.PubMedGoogle Scholar
Rodríguez-Trujillo A, Cobo T, Vives I, Bosch J, Kacerovsky M, Posadas DE, et al. Gestational age is more important for short-term neonatal outcome than microbial invasion of the amniotic cavity or intra-amniotic inflammation in preterm prelabor rupture of membranes. Acta Obstet Gynecol Scand. 2016;95(8):926–33. https://doi.org/10.1111/aogs.12905.CrossRefPubMedGoogle Scholar