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Mitochondrial communication in the context of aging

  • Konstantinos Lefkimmiatis
  • Francesca Grisan
  • Liliana F. Iannucci
  • Nicoletta C. Surdo
  • Tullio PozzanEmail author
  • Giulietta Di BenedettoEmail author
Short Communication

Abstract

Mitochondria constantly contribute to the cell homeostasis and this, during the lifespan of a cell, takes its toll. Indeed, the functional decline of mitochondria appears correlated to the aging of the cell. The initial idea was that excessive production of reactive oxygen species (ROS) by functionally compromised mitochondria was the causal link between the decline of the organelle functions and cellular aging. However, in recent years accumulating evidence suggests that the contribution of mitochondria to cellular aging goes beyond ROS production. In this short review, we discuss how intracellular signalling, specifically the cAMP-signalling cascade, is involved in the regulation of mitochondrial functions and potentially in the processes that link mitochondrial status to cellular aging.

Keywords

cAMP Signalling Mitochondria Aging 

Notes

Funding

This work was supported by the National Research Council of Italy (CNR), Research Project “Aging: molecular and technological innovations for improving the health of the elderly population” (Prot. MIUR 2867 25.11.2011).

Compliance with ethical standard

Conflict of interest

On behalf of all authors, the corresponding authors state that there is no conflict of interest.

Statement of human and animal rights

In the original work by the authors all applicable international, national, and/or institutional guidelines for the care and use of animals were followed. This article does not contain any studies with human participants performed by any of the authors.

Informed consent

Not applicable.

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of Molecular MedicineUniversity of PaviaPaviaItaly
  2. 2.Veneto Institute of Molecular MedicineFoundation for Advanced Biomedical ResearchPadovaItaly
  3. 3.Neuroscience InstituteNational Research Council of Italy (CNR)PadovaItaly
  4. 4.Department of Biomedical SciencesUniversity of PadovaPadovaItaly
  5. 5.Department of BiologyUniversity of PadovaPadovaItaly

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