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Efficacy and safety of endoscopic submucosal dissection for gastric epithelial neoplasia in elderly patients aged 80 years and older

  • Young Woong Son
  • Ain Kim
  • Han Ho JeonEmail author
Original Article
  • 18 Downloads

Abstract

Background

Endoscopic submucosal dissection (ESD) has been widely used in gastric tumor as a minimally invasive treatment. The efficacy and safety of ESD is still unclear in the elderly who have high frequency comorbidities. The aim of this study is to evaluate the efficacy and safety of ESD for gastric epithelial neoplasia in patients aged 80 years and older.

Methods

Between March 2013 and July 2017, a total of 438 gastric epithelial neoplasia patients treated with ESD were analyzed. Clinical outcomes including en bloc and complete resection rates, adverse events (AE) related procedure and sedation were compared between the elderly group and the non-elderly group.

Results

Sex, Body Mass Index, medication history and American Society of Anesthesiologists physical status did not differ between the two groups. Tumor characteristics except size of resected specimen (elderly vs. non-elderly; 36.5 ± 10.5 vs. 32.3 ± 8.7 mm, p < 0.011) did not differ. There were no significant differences in AE-related sedation. En bloc resection (elderly vs. non-elderly; 100% vs. 98.3%, p = 0.454), and complete resection rate (elderly vs. non-elderly; 93.8% vs. 96.3%, p = 0.471) did not differ significantly between the two groups. Procedure time, hospital stay, AE-related procedure and delayed bleeding were also similar between the two groups. However, procedure time of preventive hemostasis (elderly vs. non-elderly; 10.4 ± 7.7 vs. 7.4 ± 5.2 min, p = 0.040) was significantly higher in the elderly group.

Conclusions

ESD for gastric epithelial neoplasia is effective and safe in elderly patients ≥ 80 years as in non-elderly patients.

Keywords

Endoscopic submucosal dissection Elderly Gastric epithelial neoplasia 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare no funding source or conflicts of interest to declare.

Ethical approval

This retrospective study had been approved by the Institutional Review Board at National Health Insurance Service Ilsan Hospital (no. 2017-08-007-001).

Informed consent

For this kind of study formal consent is note required.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Division of Gastroenterology, Department of Internal MedicineNational Health Insurance Service Ilsan HospitalGoyang-siSouth Korea
  2. 2.Department of Human BiologyUniversity of TorontoTorontoCanada

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