Aging Clinical and Experimental Research

, Volume 31, Issue 3, pp 361–366 | Cite as

Six-month observational follow-up on activities of daily living in people with dementia living in nursing homes after a 6-month group based on either exercise or social activities

  • Mathieu MaltaisEmail author
  • Yves Rolland
  • Paul-Emile Haÿ
  • Didier Armaingaud
  • Bruno Vellas
  • Philipe de Souto Barreto
Original Article



Studies have demonstrated changes in activities of daily living after an exercise intervention in people with dementia (PWD) living in nursing homes (NH). However, some discrepancies are shown during follow-up.


Our objective was to measure activities of daily living (ADL) performance during a 6-month observational follow-up after a 6-month exercise or social activity intervention in PWD living in NH.


After cluster randomisation, 91 PWD living in NH performed a 6-month structured exercise intervention (n = 44) or a social activity intervention (n = 47). After the intervention, 85 PWD were assessed for post-intervention follow-up. Instrumental and basic activities of daily living (IADL, ADL) were measured at 6-month observational follow-up after the intervention using the Alzheimer’s Disease Cooperative Study Activities of Daily Living Inventory for Severe Alzheimer’s Disease (ADCS-ADL-sev) scale (scores ranging from 0 to 51, higher is better).


Compared to participants in the social activity, those who participated to the exercise intervention had a significant decrease of their ADCS-ADL-sev score (between-group adjusted mean difference: 4.6 points, p = 0.001) with IADL having the most decrease (2.8 points, p = 0.004).


Unexpectedly, exercisers declined sharply in the performance of ADLs and IADLs, whereas participants in the social intervention group maintained their levels. The potential mechanisms to explain these findings remain still to be elucidated.


Physical function Follow-up Dementia Institution Detraining 



We would like to thank Arnaud Lendrieux (Direction de la Recherche et de l’Innovation, CHU-Toulouse) and Yasmine Messaoudi and Aude Letty (Fondation Bien Vieillir Korian) for their work, which contributed to the successful completion of the LEDEN study.


This work was funded by the Mission Recherche from the Direction de la Recherche, des Études, de l’Évaluation et des Statistiques (MiRE-DREES) (HPA-S4-03) and by the Caisse Nationale de Solidarité pour l’Autonomie (CNSA) (HPA-S4-03) in the call released by the IReSP in 2013. The Centre Hospitalier Universitaire of Toulouse (CHU Toulouse) (14 7292 03) is the sponsor of this study.

Compliance with ethical standards

Conflict of interest

Drs. Armaingaud and Haÿ are both employees of the Korian group. No other conflict of interests is present.

Statement of human and animal rights

The study protocol was approved by the ethics committee (CPP SOOM III), which was registered in a clinical trial registry (registration NCT02444078).

Informed consent

Informed consent was obtained from all individual participants, or their legal representatives, included in the study.

Sponsor’s role

Both the sponsor and funding agencies of the LEDEN study had no role in the design of this study and will not have any role in the execution of the interventions, in the analyses and interpretation of the data, or in the decision to submit results.

Supplementary material

40520_2018_984_MOESM1_ESM.pdf (140 kb)
Supplementary material 1 (PDF 140 KB)


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Gérontopôle de Toulouse, Institut du Vieillissement, Bâtiment BCentre Hospitalo-Universitaire de ToulouseToulouseFrance
  2. 2.UMR INSERM, 1027 University of Toulouse IIIToulouseFrance
  3. 3.Fondation Bien Vieillir KorianParisFrance

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