Aging Clinical and Experimental Research

, Volume 31, Issue 2, pp 193–199 | Cite as

Two years of maintenance hemodialysis has a pronounced effect on arterial stiffness progression

  • Agne Laucyte-CibulskieneEmail author
  • Laurynas Rimsevicius
  • Liutauras Gumbys
  • Dileta Valanciene
  • Marius Miglinas
Original Article



The change of aortic stiffness, but not the particular baseline value, plays a crucial role in estimating the patient risk with end-stage renal disease. Therefore, we aimed to analyze the evolution of central and peripheral arterial stiffness in hemodialysis population without previous cardiovascular events during a 2-year follow-up.


60 hemodialysis patients (mean age 57.61 ± 13.01 years) were prospectively interviewed, and they underwent blood tests, chest X-ray for aortic calcification evaluation and pulse wave velocity (PWV) measurements at the baseline, after 6 months and after 2 years of observation period.


We found significant progression of aortic PWV (12.73 vs. 14.24 m/s, p = 0.032) and regression of brachial PWV (11.53 vs. 8.85 m/s, p < 0.001). CRP increase influenced evolution of aortic PWV (β = 0.331, p = 0.031, R2 = 0.599). Higher β2-microglobulin values was related to the progression of aortic PWV (β = 0.219, p = 0.022, R2 = 0.568). Mean arterial blood pressure had influence only on the short-term arterial stiffness evolution.


Patients on maintenance hemodialysis experience pronounced changes of arterial stiffness during the 2-year follow-up period. The progression of aortic stiffness is related to inflammatory response and particularly is influenced by β2-microglobulin concentration and aortic calcification.


Arterial stiffness Dialysis Progression Pulse wave velocity Vascular remodeling 



The authors are grateful to Modesta Petraviciute and Migle Gudynaite for data collection, to Dialysis Department personnel for blood sample collection, to Dr. Ligita Ryliskyte and Kristina Galiauskiene for scientific and technical advises in measuring pulse wave velocity. On behalf of all authors, special thanks to Tetsuya Ogawa from Division of Blood Purification and Nephrology, Department of Medicine, Tokyo Women’s Medical University Medical Center, for providing a sample of aortic arch calcification score and sharing the methodology.

Compliance with ethical standards

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical approval

This study was conducted with all the subjects’ written informed consent and in accordance with the 1964 Helsinki declaration and its later amendments. It was also approved by the Vilnius Regional Biomedical Research Ethics Committee (Permission Nr.1582000-14-750-268).

Informed consent

Patients were informed, and they consented to conduct the study.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Clinic of Gastroenterology, Nephrourology and Abdominal Surgery, Institute of Clinical Medicine, Faculty of MedicineVilnius UniversityVilniusLithuania
  2. 2.Department of Radiology, Nuclear Medicine and Medical Physics, Faculty of MedicineVilnius UniversityVilniusLithuania

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