Aging Clinical and Experimental Research

, Volume 31, Issue 1, pp 157–160 | Cite as

Supplemented amino acids may enhance the walking recovery of elderly subjects after hip fracture surgery

  • Roberto Aquilani
  • Carlo Zuccarelli Ginetto
  • Carla Rutili
  • Pietro Pisano
  • Evasio Pasini
  • Eleonora Baldissarro
  • Manuela Verri
  • Federica BoschiEmail author
Short Communication


The purpose of this study was to investigate whether supplemented essential amino acids (EAAs) could enhance rehabilitation therapy (Rehab) for recovery of walking capacity in subjects after hip fracture surgery (HFS). Eighty-three elderly subjects with HFS (20 ± 11 days after acute trauma) were eligible for the study and randomized to receive Rehab only (Rehab; n = 27), Rehab + placebo (RP; n = 28) or Rehab + EAAs (RE 8 g/day; n = 28). The patients’ walking capacity (m) was measured by 6-min walking distance (6MWD) at admission and at discharge (median 66 days after admission). All patient groups were treated with the same Rehab (2 sessions/day × 5 days/week). The results showed that the gain in 6MWD was higher in RE than in Rehab and RP (p = 0.034; p = 0.024). The study shows that EAA supplementation can enhance walking recovery rate in subjects with HFS.


Hip fracture Amino acids Walking test 



The authors would like to thank Prof. Robert Coates (Centro Linguistico, Bocconi University, P. zale Sarfatti, Milano, Italy), medical writer and editor, for his linguistic revision.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study was approved by the scientific ethics committee of the institute (Direzione Generale/Atti/2008/FF/R002/13.2.2008).

Informed consent

All subjects gave their informed written consent.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Roberto Aquilani
    • 1
  • Carlo Zuccarelli Ginetto
    • 2
  • Carla Rutili
    • 2
  • Pietro Pisano
    • 2
  • Evasio Pasini
    • 3
  • Eleonora Baldissarro
    • 4
  • Manuela Verri
    • 1
  • Federica Boschi
    • 5
    Email author
  1. 1.Dipartimento di Biologia e Biotecnologie Università degli Studi di PaviaPaviaItaly
  2. 2.Istituto Geriatrico P. Redaelli -Reparti di Riabilitazione Geriatrica e di MantenimentoVimodroneItaly
  3. 3.Divisione di Riabilitazione Cardiologica, Centro Medico di LumezzaneIstituti Clinici Scientifici “Maugeri”, IRCCSLumezzaneItaly
  4. 4.Dipartimento di Medicina Fisica e Riabilitativa, Centro Medico di NerviIstituti Clinici Scientifici “Maugeri”, IRCCSNerviItaly
  5. 5.Dipartimento di Scienze del FarmacoUniversità degli Studi di PaviaPaviaItaly

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