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Aging Clinical and Experimental Research

, Volume 30, Issue 9, pp 1059–1070 | Cite as

Associations between age and 50 trace element contents and relationships in intact thyroid of males

  • Vladimir Zaichick
  • Sofia Zaichick
Original Article
  • 40 Downloads

Abstract

Background

It is unclear why a prevalence of thyroid dysfunction is higher in the elderly as compared to the younger population. An excess or deficiency of trace element contents in thyroid may play important role in goitre- and carcinogenesis of gland.

Aim

To examine the variation with age of the mass fraction of 50 trace elements in intact (normal) male thyroid.

Method

Samples of thyroid parenchyma obtained from 72 healthy males (mean age 37.8 years, range 2–80 years) was investigated. Measurements were performed using a combination of non-destructive and destructive methods: instrumental neutron activation analysis and inductively coupled plasma mass spectrometry, respectively. Tissue samples were divided into two portions. One was used for morphological study while the other was intended for trace element analysis.

Results

There is a statistically significant increase in Cd and Se mass fraction, as well as a decrease in Al, Be, Dy, Ga, Gd, Li, Mn, U, and Y mass fraction in the normal thyroid of male during a lifespan. Moreover, a disturbance of intra-thyroidal chemical element relationships (correlations) with increasing age was found.

Discussion

Our findings suggest that, at least, a goitrogenic and carcinogenic effect of Cd overload and Mn deficiency in the thyroid of old males may be assumed. Many trace elements in human thyroid behave themselves as antagonists or synergists. Therefore, an age-related disturbance in correlations between Mn and other trace element mass fractions in thyroid parenchyma may also contribute to harmful effects on the gland.

Conclusion

Age-related changes in intra-thyroidal trace element contents and disturbances in trace element relationships are involved in goitre- and carcinogenesis.

Keywords

Thyroid Chemical elements Age-related changes Neutron activation analysis Inductively coupled plasma mass spectrometry 

Notes

Acknowledgements

We are grateful to Dr. Yu. Choporov, Head of the Forensic Medicine Department of City Hospital, Obninsk, for supplying thyroid samples. We are also grateful to Dr. Karandaschev V., Dr. Nosenko S., and Moskvina I., Institute of Microelectronics Technology and High Purity Materials, Chernogolovka, Russia, for their help in ICP-MS analysis.

Compliance with ethical standards

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest aside from grant funding stated above.

Informed Consent

For this type of study formal consent is not required.

Statement of human and animal rights.

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Supplementary material

40520_2018_906_MOESM1_ESM.docx (33 kb)
Supplementary material 1 (DOCX 33 KB)

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Radionuclide Diagnostics DepartmentMedical Radiological Research CentreObninskRussia
  2. 2.Laboratory of Dr. Gabriela CaraveoPiso, Feinberg School of MedicineNorthwestern UniversityChicagoUSA

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