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A case of right Alzheimer’s disease

  • Carlo AbbateEmail author
  • Pietro D. Trimarchi
  • Silvia Inglese
  • Sarah Damanti
  • Giulia A. M. Dolci
  • Simona Ciccone
  • Paolo D. Rossi
  • Daniela Mari
  • Beatrice Arosio
  • Matteo Cesari
Case Report

Introduction

Early imaging studies found that a subgroup of patients with Alzheimer’s disease (AD) showed preponderant visuospatial impairments and consensual hypometabolism in the PET scan, especially prevalent at the right parietal region [1]. The term right Alzheimer’s disease (RAD) was used to name this clinical and anatomical presentation of AD. However, the RAD syndrome has rarely been described in detail. Moreover, early cases of RAD seemed to share some features of the posterior cortical atrophy (PCA) syndrome of AD [2]. More recently, the concept of RAD has been proposed by some authors when explaining the heterogeneity of the AD and the different forms animating this condition. In particular, Lam et al. [3] described the case of a woman with early-onset AD presenting with short-term memory deficits and difficulties at visually guided tasks; her symptoms seemed to be characterized by temporal and parietal cortical involvement, especially of the right parietal region. The...

Keywords

Alzheimer’s disease (AD) Variant of AD Left–right asymmetry Right AD (RAD) Visuospatial 

Notes

Acknowledgements

Special thanks are due to the patient SR and her son for their long-standing cooperation in testing and clinical interviews. Moreover, we thank Luigi Flaminio Ghilardini a lot for his help in editing the digital figures.

Funding

None.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Statement of human and animal rights

The study has been approved by the institutional research committe of the Fondazione Ca' Granda and has been performed in accordance with the ethical standards of the Fondazione Ca' Granda and with the 1964 Helsinki Declaration and its later amendments.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

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Supplementary material 1 (TIF 1031 KB)
40520_2018_1116_MOESM2_ESM.doc (133 kb)
Supplementary material 2 (DOC 135 KB)

References

  1. 1.
    Foster NL, Chase TN, Fedio P et al (1983) Alzheimer’s disease focal cortical changes shown by positron emission tomography. Neurology 33:961–961CrossRefGoogle Scholar
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    Crutch SJ, Schott JM, Rabinovici GD et al (2017) Consensus classification of posterior cortical atrophy. Alzheimers Dement 13:870–884.  https://doi.org/10.1016/j.jalz.2017.01.014 CrossRefGoogle Scholar
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    Lam B, Masellis M, Freedman M et al (2013) Clinical, imaging, and pathological heterogeneity of the Alzheimer’s disease syndrome. Alzheimers Res Ther 5:1CrossRefGoogle Scholar
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    Fisher NJ, Rourke BP, Bieliauskas LA et al (1997) Unmasking the heterogeneity of Alzheimer’s disease: case studies of individuals from distinct neuropsychological subgroups. J Clin Exp Neuropsychol 19:713–754CrossRefGoogle Scholar
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    Kumfor F, Landin-Romero R, Devenney E et al (2016) On the right side? A longitudinal study of left-versus right-lateralized semantic dementia. Brain 139:986–998CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Carlo Abbate
    • 1
    Email author
  • Pietro D. Trimarchi
    • 2
  • Silvia Inglese
    • 1
  • Sarah Damanti
    • 1
    • 3
  • Giulia A. M. Dolci
    • 4
  • Simona Ciccone
    • 1
  • Paolo D. Rossi
    • 1
  • Daniela Mari
    • 3
  • Beatrice Arosio
    • 3
  • Matteo Cesari
    • 1
    • 3
  1. 1.Geriatric Unit, Fondazione IRCCS Ca’ GrandaOspedale Maggiore PoliclinicoMilanItaly
  2. 2.Fondazione IRCCS Don Carlo GnocchiMilanItaly
  3. 3.Department of Medical Sciences and Community HealthUniversity of MilanMilanItaly
  4. 4.A.S.P. Pio Albergo TrivulzioMilanItaly

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