Aging Clinical and Experimental Research

, Volume 29, Issue 1, pp 89–100 | Cite as

The “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies” (SPRINTT) randomized controlled trial: design and methods

  • Francesco LandiEmail author
  • Matteo Cesari
  • Riccardo Calvani
  • Antonio Cherubini
  • Mauro Di Bari
  • Raphael Bejuit
  • Jerome Mshid
  • Sandrine Andrieu
  • Alan J. Sinclair
  • Cornel C. Sieber
  • Bruno Vellas
  • Eva Topinkova
  • Timo Strandberg
  • Leocadio Rodriguez-Manas
  • Fabrizia Lattanzio
  • Marco Pahor
  • Ronenn Roubenoff
  • Alfonso J. Cruz-Jentoft
  • Roberto Bernabei
  • Emanuele MarzettiEmail author
  • on behalf of the SPRINTT Consortium
Original Article


The sustainability of health and social care systems is threatened by a growing population of older persons with heterogeneous needs related to multimorbidity, frailty, and increased risk of functional impairment. Since disability is difficult to reverse in old age and is extremely burdensome for individuals and society, novel strategies should be devised to preserve adequate levels of function and independence in late life. The development of mobility disability, an early event in the disablement process, precedes and predicts more severe forms of inability. Its prevention is, therefore, critical to impede the transition to overt disability. For this reason, the Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies (SPRINTT) project is conducting a randomized controlled trial (RCT) to test a multicomponent intervention (MCI) specifically designed to prevent mobility disability in high-risk older persons. SPRINTT is a phase III, multicenter RCT aimed at comparing the efficacy of a MCI, based on long-term structured physical activity, nutritional counseling/dietary intervention, and an information and communication technology intervention, versus a healthy aging lifestyle education program designed to prevent mobility disability in 1500 older persons with physical frailty and sarcopenia who will be followed for up to 36 months. The primary outcome of the SPRINTT trial is mobility disability, operationalized as the inability to walk for 400 m within 15 min, without sitting, help of another person, or the use of a walker. Secondary outcomes include changes in muscle mass and strength, persistent mobility disability, falls and injurious falls, disability in activities of daily living, nutritional status, cognition, mood, the use of healthcare resources, cost-effectiveness analysis, quality of life, and mortality rate. SPRINTT results are expected to promote significant advancements in the management of frail older persons at high risk of disability from both clinical and regulatory perspectives. The findings are also projected to pave the way for major investments in the field of disability prevention in old age.


Disability Functional impairment Physical activity Nutrition Prevention Unmet needs 



The present work was funded by a grant from the Innovative Medicines Initiative—Joint Undertaking (IMI-JU 115621). The work was also partly supported by the “Centro Studi Achille e Linda Lorenzon” (E.M., R.C.), Fondazione Roma (NCDs Call for Proposals 2013; E.M., R.C.), and intramural research grants from the Catholic University of the Sacred Heart (D3.2 2013 and D3.2 2015; E.M., F.L., R.C.).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

For this type of study, informed consent is not required.


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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  • Francesco Landi
    • 1
    Email author
  • Matteo Cesari
    • 2
    • 3
  • Riccardo Calvani
    • 1
  • Antonio Cherubini
    • 4
  • Mauro Di Bari
    • 5
    • 6
  • Raphael Bejuit
    • 7
  • Jerome Mshid
    • 7
  • Sandrine Andrieu
    • 8
    • 9
  • Alan J. Sinclair
    • 10
  • Cornel C. Sieber
    • 11
  • Bruno Vellas
    • 2
  • Eva Topinkova
    • 12
  • Timo Strandberg
    • 13
    • 14
    • 15
  • Leocadio Rodriguez-Manas
    • 16
  • Fabrizia Lattanzio
    • 4
  • Marco Pahor
    • 17
  • Ronenn Roubenoff
    • 18
  • Alfonso J. Cruz-Jentoft
    • 19
  • Roberto Bernabei
    • 1
  • Emanuele Marzetti
    • 1
    Email author
  • on behalf of the SPRINTT Consortium
  1. 1.Department of Geriatrics, Neurosciences and OrthopedicsCatholic University of the Sacred Heart School of MedicineRomeItaly
  2. 2.GérontopôleCentre Hospitalier Universitaire de ToulouseToulouseFrance
  3. 3.Université de Toulouse III Paul SabatierToulouseFrance
  4. 4.Geriatrics and Geriatric Emergency CareIRCCS-INRCAAnconaItaly
  5. 5.Research Unit of Medicine of Aging, Department of Experimental and Clinical MedicineUniversity of FlorenceFlorenceItaly
  6. 6.Division of Geriatric Cardiology and Medicine, Department of Geriatrics and MedicineAzienda Ospedaliero-Universitaria CareggiFlorenceItaly
  7. 7.Sanofi R&DParisFrance
  8. 8.INSERM-Toulouse University UMR1027ToulouseFrance
  9. 9.Department of Epidemiology and Public HealthCHU ToulouseToulouseFrance
  10. 10.Foundation for Diabetes Research in Older PeopleDiabetes Frail LtdDroitwich SpaUK
  11. 11.Institute for Biomedicine of AgingFriedrich-Alexander UniversityNurembergGermany
  12. 12.Department of Geriatrics, First Faculty of MedicineCharles UniversityPragueCzech Republic
  13. 13.Department of Internal Medicine and GeriatricsUniversity of HelsinkiHelsinkiFinland
  14. 14.Clinics of Internal Medicine and GeriatricsHelsinki University Central HospitalHelsinkiFinland
  15. 15.Unit of General PracticeOulu University HospitalOuluFinland
  16. 16.Service of GeriatricsGetafe University HospitalMadridSpain
  17. 17.Department of Aging and Geriatric ResearchUniversity of FloridaGainesvilleUSA
  18. 18.Global Translational MedicineNovartis Institutes for Biomedical ResearchBaselSwitzerland
  19. 19.Geriatric DepartmentUniversity Hospital Ramón y CajalMadridSpain

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