The role of DXA in sarcopenia
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Sarcopenia is a condition characterized by progressive and generalized reduction in skeletal muscle mass and muscle strength, associated with an increased risk of adverse outcomes (disability, hospitalization, death). The growing attention in the last years, aiming to establish a consensus definition and treatment, reflects the interest of the scientific community toward this complex condition, which has many implications in clinical practice and public health. Dual-energy X-ray absorptiometry (DXA) is the gold-standard technique in the analysis of body composition at molecular level, providing assessment and quantification of fat mass, lean mass and bone mineral content, both in a single body region of interest and at whole-body level. In particular, through the assessment of non-bone lean mass parameters, such as appendicular lean mass adjusted for BMI or height (ALM/BMI and ALM/ht2, respectively), it is possible to discriminate subjects with “physiological” loss of muscle mass from those with “pathological” impoverishment of this compartment, referring to specific cutoff values validated in the literature, but keeping in mind the lack of standardization of DXA measures. In addition, it is useful in treatment planning, estimating resting energy expenditure, and in follow-up, because it allows quantifying with high reproducibility the modifications in BC, distinguishing when the change is biological (deterioration due to a progression of the disease or improvement due to treatment). Due to DXA favorability in terms of accuracy, simplicity, availability, low cost and low radiation exposure, its role in sarcopenia diagnosis is becoming increasingly important, emerging as reference assessment technique in muscle mass evaluation.
KeywordsSarcopenia Aging Absorptiometry Photon Muscle Body composition Diagnosis
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- 60.Trippo U, Koebnick C, Zunft HJ et al (2004) Bioelectrical impedance analysis for predicting body composition: what about the external validity of new regression equations? Am J Clin Nutr 79:335–336; author reply 336–337Google Scholar
- 68.The 2007 Recommendations of the International Commission on Radiological Protection. ICRP publication 103 (2007). Ann ICRP 37:1–332. doi: 10.1016/j.icrp.2007.10.003
- 70.McCollough CH, Schueler BA, Atwell TD et al (2007) Radiation exposure and pregnancy: when should we be concerned? Radiographics 27:909–917; discussion 917–908. doi: 10.1148/rg.274065149
- 71.Sala A, Webber C, Halton J et al (2006) Effect of diagnostic radioisotopes and radiographic contrast media on measurements of lumbar spine bone mineral density and body composition by dual-energy X-ray absorptiometry. J Clin Densitom 9:91–96. doi: 10.1016/j.jocd.2005.10.003 PubMedCrossRefGoogle Scholar
- 94.Hangartner TN, Warner S, Braillon P et al (2013) The Official Positions of the International Society for Clinical Densitometry: acquisition of dual-energy X-ray absorptiometry body composition and considerations regarding analysis and repeatability of measures. J Clin Densitom 16:520–536. doi: 10.1016/j.jocd.2013.08.007 PubMedCrossRefGoogle Scholar
- 101.van Pelt RE, Dinneno FA, Seals DR et al (2001) Age-related decline in RMR in physically active men: relation to exercise volume and energy intake. Am J Physiol Endocrinol Metabol 281:E633–E639Google Scholar
- 103.Usui C, Taguchi M, Ishikawa-Takata K et al (2012) The validity of body composition measurement using dual energy X-ray absorptiometry for estimating resting energy expenditure. In: El Maghraoui A (ed) Dual energy X-ray absorptiometry. ISBN: 978-953-307-877-9Google Scholar