Aging Clinical and Experimental Research

, Volume 28, Issue 1, pp 83–88 | Cite as

Implications of palonosetron in elderly patients undergoing laparoscopic cholecystectomy with respect to its anti-shivering effect

  • Youn Yi Jo
  • Yong Beom Kim
  • Dongchul Lee
  • Young Jin Chang
  • Hyun Jeong KwakEmail author
Original Article



The elderly are vulnerable to hypothermia and have a higher risk of cardiovascular events induced by marked increases in oxygen consumption due to shivering. Five-hydroxytryptamine-3 (5-HT3) receptor antagonists have been previously reported to reduce post-anesthesia shivering.


In the present study, the authors investigated the effects of palonosetron, a new-generation 5-HT3 antagonist, on core hypothermia and the incidence of shivering after laparoscopic cholecystectomy in elderly patients.


Forty-eight patients (65–80 years) were randomly assigned to one of two groups and administered palonosetron 0.075 mg (palonosetron group, n = 24) or the same volume of normal saline (control group, n = 24) before anesthesia induction. Core body temperatures and hemodynamic variables were monitored during and after operation. Post-anesthetic shivering (PAS) and pain scores were obtained in a post-anesthetic care unit.


Intraoperative esophageal temperature changed significantly over time (P = 0.010), but significant intergroup difference in change was not observed (P = 0.706). Furthermore, shivering frequencies were similar in the two groups (P = 0.610). However, postoperative pain scores at 30 min after entering the post-anesthesia care unit were significantly lower in the palonosetron group (P = 0.002).


Regardless of the previously reported anti-shivering effect of 5-HT3 receptor antagonists, pre-operative palonosetron 0.075 mg did not influence perioperative hypothermia or PAS in this study. This discrepancy might be due to the dose responsiveness of palonosetron to PAS and relatively low incidence of PAS in the elderly.


Pre-operative administration of palonosetron 0.075 mg did not influence perioperative hypothermia or post-anesthesia shivering in elderly patients undergoing laparoscopic cholecystectomy. However, palonosetron might be beneficial for reducing early postoperative pain in elderly patients with opioid-based patient-controlled analgesia.


Post-anesthetic shivering Palonosetron Elderly 


Conflict of interest

The authors have no potential conflict of interest to declare.

Human and Animal Rights

The study was conducted according to standards derived from the Declaration of Helsinki.

Informed consent

A written informed consent was obtained from every patient.


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Youn Yi Jo
    • 1
  • Yong Beom Kim
    • 1
  • Dongchul Lee
    • 1
  • Young Jin Chang
    • 1
  • Hyun Jeong Kwak
    • 1
    Email author
  1. 1.Department of Anesthesiology and Pain Medicine, Gil Medical CenterGachon UniversityIncheonSouth Korea

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