The effects of aging on the brain activation pattern during a speech perception task: an fMRI study
- 212 Downloads
In the present study, brain activation associated with speech perception processing was examined across four groups of adult participants with age ranges between 20 and 65 years, using functional MRI (fMRI). Cognitive performance demonstrates that performance accuracy declines with age. fMRI results reveal that all four groups of participants activated the same brain areas. The same brain activation pattern was found in all activated areas (except for the right superior temporal gyrus and right middle temporal gyrus); brain activity was increased from group 1 (20–29 years) to group 2 (30–39 years). However, it decreased in group 3 (40–49 years) with further decreases in group 4 participants (50–65 years). Result also reveals that three brain areas (superior temporal gyrus, Heschl’s gyrus and cerebellum) showed changes in brain laterality in the older participants, akin to a shift from left-lateralized to right-lateralized activity. The onset of this change was different across brain areas. Based on these findings we suggest that, whereas all four groups of participants used the same areas in processing, the engagement and recruitment of those areas differ with age as the brain grows older. Findings are discussed in the context of corroborating evidence of neural changes with age.
KeywordsfMRI Speech perception processing Neural deterioration Brain laterality
We thank Sa’don Samian from Department of Radiology, Universiti Kebangsaan Malaysia Medical Centre, for the assistance in fMRI scans. We also thank Mohammad Hairol Isa from Jabatan Kesihatan Masyarakat Universiti Kebangsaan Medical Centre, for his help on managing older participants. We also thank Noorazrul Azmie Yahya from Diagnostic Imaging and Radiotherapy Program, School of Diagnostic and Applied Health Sciences, for his ideas, and insight. This work is supported by the Research University Grant UKM GUP-SK-07-020-205.
Conflict of interest
The author certify that there is no actual or potential conflict of interest in relation to this article.
- 19.Manan HA, Yusoff AN, Franz EA, Mukari SZM (2013) The effects of background noise on brain activity using speech stimuli on healthy young adults. Neurol Psychiatry Brain Res 19:207–215Google Scholar
- 20.Manan HA, Franz EA, Yusoff AN, Mukari SZM (2013) Age-related laterality shifts in auditory and attention networks with normal ageing: effects on a working memory task. Neurol Psychiatry Brain Res 19:180–191Google Scholar
- 25.Celsis P, Boulanouar K, Doyon P, Ranjeva JP, Berry I, Nespoulous JL, Chollet F (1999) Differential fMRI responses in the left posterior superior temporal gyrus and left supramarginal gyrus to habituation and change detection in syllables and tones. NeuroImage 9(1):135–144PubMedCrossRefGoogle Scholar
- 38.Cabeza R, Dennis NA (2012) Frontal lobes and aging; deterioration and compensation. In: Stuss DT, Knight RT (eds) Principles of frontal lobe function, 2nd edn. Oxford University Press, Oxford, pp 628–652Google Scholar
- 40.Reuter-Lorenz PA, Sylvester CYC, Cabeza R, Nyberg L, Park D (2005) The cognitive neuroscience of working memory and aging. In: Cognitive neuroscience of aging: linking cognitive and cerebral aging. Oxford University Press, New York, pp 186–121Google Scholar
- 42.Balsamo LM, Benjamin MA, Cecile BG, Jeffrey RP, Braniecki SH, Elliott TK, Gaillard DW (2002) A functional magnetic resonance imaging study of left hemisphere language dominance in children. JAMA Neurol 59(7):1168–1174Google Scholar
- 45.Cabeza R, Nyberg L, Park D (2005) Cognitive neuroscience of aging: linking cognitive and cerebral aging. Oxford University Press, New YorkGoogle Scholar
- 46.Kemper S (2000) Over- and under-accommodations to aging. In: Charness N, Parks DC, Sabel BA (eds) Communication, technology, and aging. Springer, DoylestownGoogle Scholar