Changes in body composition and use of blood cholesterol lowering drugs predict changes in blood lipids during 12 weeks of resistance exercise training in old adults
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Aging is associated with an impairment of blood lipids. The present study investigated the response of blood lipids to resistance exercise in old adults. The particular aim was to investigate whether the response of blood lipids is associated with changes in body composition of blood lipid medication.
Subjects (N = 236, 73.7 ± 5.7 years, 58.2 % female) participated in a 12-week resistance exercise program (3 times/week; 3 sets, 6–8 repetitions at 75–80 % of the 1-repetition maximum), designed to increase strength and muscle mass of major muscle groups. Body composition, drug use, triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) were assessed at baseline and endpoint.
The concentrations of HDL (−6 mg/dl), LDL (−18 mg/dl), TC (−26 mg/dl) and TG (−12 mg/g) decreased significantly during the study period. A reduction in fat mass by 1 kg predicted a reduction in TG (5.0 mg/dl, P = 0.017) and a gain in lean body mass by 1 kg predicted also a reduction in TG (−4.5 mg/dl, P = 0.023). The use of blood cholesterol lowering drugs predicted greater reductions in TC (−16.9 mg/dl, P = 0.032) and LDL (−11.8 mg/dl, P = 0.038) during training.
TG, TC, LDL and HDL decreased significantly after 12 weeks of progressive resistance exercise in old adults. Changes in body composition, i.e., reduction in fat mass and gain in lean body mass improved the blood lipid profile. Use of blood lipid lowering drugs was associated with greater reductions in TC and LDL after the training.
KeywordsResistance exercise Blood lipids Old adults Blood cholesterol lowering drugs
This study was part of the IceProQualita project, which was funded by the Icelandic Technology Development Fund (No. 071323008), Research Fund of the University of Iceland, a grant from Landspitali University Hospital Research Fund and the Helga Jonsdottir and Sigurlidi Kristjansson Geriatric Research Fund. The trial is registered at the US National Library of Medicine (Nr. NCT01074879).
Conflict of interest
The authors declare no conflict of interest.
- 3.Adams SP, Tsang M, Wright JM (2012) Lipid lowering efficacy of atorvastatin. Cochrane Database Syst Rev. 12:CD008226Google Scholar
- 4.Mansikkaniemi K, Juonala M, Taimela S, Hirvensalo M, Telama R, Huupponen R, Saarikoski L, Hurme M, Mallat Z, Benessiano J, Jula A, Taittonen L, Marniemi J, Kähönen M, Lehtimäki T, Rönnemaa T, Viikari J, Raitakari OT (2012) Cross-sectional associations between physical activity and selected coronary heart disease risk factors in young adults. The Cardiovascular Risk in Young Finns Study. Ann Med 44:733–744PubMedCrossRefGoogle Scholar
- 7.Kujala UM, Mäkinen VP, Heinonen I, Soininen P, Kangas AJ, Leskinen TH, Rahkila P, Würtz P, Kovanen V, Cheng S, Sipilä S, Hirvensalo M, Telama R, Tammelin T, Savolainen MJ, Pouta A, O‘Reilly PF, Mäntyselkä P, Viikari J, Kähönen M, Lehtimäki T, Elliott P, Vanhala MJ, Raitakari OT, Järvelin MR, Kaprio J, Kainulainen H, Ala-Korpela M (2013) Long-term leisure-time physical activity and serum metabolome. Circulation 22127(3):340–348CrossRefGoogle Scholar
- 9.Greene NP, Fluckey JD, Lambert BS, Greene ES, Riechman SE, Crouse SF (2012) Regulators of blood lipids and lipoproteins? PPARδ and AMPK, induced by exercise, are correlated with lipids and lipoproteins in overweight/obese men and women. Am J Physiol Endocrinol Metab 15303:E1212–E1221CrossRefGoogle Scholar
- 17.Arnarson A, Geirsdottir OG, Ramel A, Briem K, Jonsson PV, Thorsdottir I (2013) Effects of whey proteins and carbohydrates on the efficacy of resistance training in elderly people:double blind, randomised controlled trial. Eur J Clin Nutr. (Epub ahead of print)Google Scholar
- 19.The Icelandic Food Composition Database (ISGEM). Matis ltd. Icelandic Food and Biotech R&D. http://www.matis.is/ISGEM/en/. Accessed 2013
- 28.Sillanpää E, Laaksonen DE, Häkkinen A, Karavirta L, Jensen B, Kraemer WJ, Nyman K, Häkkinen K (2009) Body composition, fitness, and metabolic health during strength and endurance training and their combination in middle-aged and older women. Eur J Appl Physiol 106:285–296PubMedCrossRefGoogle Scholar