Aging Clinical and Experimental Research

, Volume 25, Issue 5, pp 561–569 | Cite as

Effects of self-reported osteoarthritis on physical performance: a longitudinal study with a 10-year follow-up

  • Daniël M. van LeeuwenEmail author
  • Geeske M. E. E. Peeters
  • Cornelis J. de Ruiter
  • Paul Lips
  • Jos W. R. Twisk
  • Dorly J. H. Deeg
  • Arnold de Haan
Original Article


Background and aims

Osteoarthritis (OA) of the knee or hip is associated with limitations in activities of daily life. There are only a few long-term studies on how knee or hip OA affects the course of physical performance. The aim of this study was to investigate the effects of knee or hip OA on physical performance during a follow-up period of 10 years.


Participants in the Longitudinal Aging Study Amsterdam with self-reported hip or knee OA (N = 155) were prospectively followed for 10 years on 4 occasions from the onset of OA and compared to participants without OA (N = 1004). Physical performance was tested with walk, chair stand and balance tests. Scores for each test were summed to a total performance score (range 0–12), higher scores indicating better performance. Generalized estimating equations were used to analyze differences between participants with and without OA, unadjusted as well as adjusted for confounders.


There was a significant interaction between OA and sex (P = 0.068). Both in men and women, total performance was lower for participants with OA, with greater differences in men. Chair stand and walking performance (P < 0.05), but not balance, were lower in participants with OA. After adjustment for confounders, these associations remained significant in men but not in women. Additional analyses correcting for follow-up duration and attrition showed lower performance scores for men and women with OA.


OA negatively affected physical performance 3–6 years after it was first reported. Performance in men with OA was more affected than in women.


Osteoarthritis Physical functioning SPPB 


Conflict of interest



  1. 1.
    Steultjens MP, Dekker J, van Baar ME, Oostendorp RA, Bijlsma JW (2001) Muscle strength, pain and disability in patients with osteoarthritis. Clin Rehabil 15(3):331–341PubMedCrossRefGoogle Scholar
  2. 2.
    Petterson SC, Mizner RL, Stevens JE, Raisis L, Bodenstab A, Newcomb W et al (2009) Improved function from progressive strengthening interventions after total knee arthroplasty: a randomized clinical trial with an imbedded prospective cohort. Arthritis Rheum 61(2):174–183PubMedCrossRefGoogle Scholar
  3. 3.
    van Dijk GM, Dekker J, Veenhof C, van den Ende CH (2006) Course of functional status and pain in osteoarthritis of the hip or knee: a systematic review of the literature. Arthritis Rheum 55(5):779–785PubMedCrossRefGoogle Scholar
  4. 4.
    Dunlop DD, Semanik P, Song J, Sharma L, Nevitt M, Jackson R et al (2010) Moving to maintain function in knee osteoarthritis: evidence from the osteoarthritis initiative. Arch Phys Med Rehabil 91(5):714–721PubMedCrossRefGoogle Scholar
  5. 5.
    Symmons D, Mathers C, Pfleger B (2002) Global burden of osteoarthritis in the year 2000. Geneva World Health Organization, Geneva (updated 2002; cited).
  6. 6.
    van Dijk GM, Veenhof C, Spreeuwenberg P, Coene N, Burger BJ, van Schaardenburg D et al (2010) Prognosis of limitations in activities in osteoarthritis of the hip or knee: a 3-year cohort study. Arch Phys Med Rehabil 91(1):58–66PubMedCrossRefGoogle Scholar
  7. 7.
    Dunlop DD, Song J, Semanik PA, Sharma L, Chang RW (2011) Physical activity levels and functional performance in the osteoarthritis initiative: a graded relationship. Arthritis Rheum 63(1):127–136PubMedCrossRefGoogle Scholar
  8. 8.
    Palmieri-Smith RM, Thomas AC, Karvonen-Gutierrez C, Sowers MF (2010) Isometric quadriceps strength in women with mild, moderate, and severe knee osteoarthritis. Am J Phys Med Rehabil 89(7):541–548PubMedCrossRefGoogle Scholar
  9. 9.
    Miller ME, Rejeski WJ, Messier SP, Loeser RF (2001) Modifiers of change in physical functioning in older adults with knee pain: the Observational Arthritis Study in Seniors (OASIS). Arthritis Rheum 45(4):331–339PubMedCrossRefGoogle Scholar
  10. 10.
    Enright PL, Sherrill DL (1998) Reference equations for the six-minute walk in healthy adults. Am J Respir Crit Care Med 158(5 Pt 1):1384–1387PubMedCrossRefGoogle Scholar
  11. 11.
    Hairi NN, Cumming RG, Naganathan V, Handelsman DJ, Le Couteur DG, Creasey H et al (2010) Loss of muscle strength, mass (sarcopenia), and quality (specific force) and its relationship with functional limitation and physical disability: the Concord Health and Ageing in Men Project. J Am Geriatr Soc 58(11):2055–2062PubMedCrossRefGoogle Scholar
  12. 12.
    Deeg DJ, van Tilburg T, Smit JH, de Leeuw ED (2002) Attrition in the Longitudinal Aging Study Amsterdam. The effect of differential inclusion in side studies. J Clin Epidemiol 55(4):319–328PubMedCrossRefGoogle Scholar
  13. 13.
    Huisman M, Poppelaars J, van der Horst M, Beekman AT, Brug J, van Tilburg TG et al (2011) Cohort profile: the Longitudinal Aging Study Amsterdam. Int J Epidemiol 40(4):868–876PubMedCrossRefGoogle Scholar
  14. 14.
    Kriegsman DM, Penninx BW, van Eijk JT, Boeke AJ, Deeg DJ (1996) Self-reports and general practitioner information on the presence of chronic diseases in community dwelling elderly. A study on the accuracy of patients’ self-reports and on determinants of inaccuracy. J Clin Epidemiol 49(12):1407–1417PubMedCrossRefGoogle Scholar
  15. 15.
    Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG et al (1994) A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 49(2):M85–M94PubMedCrossRefGoogle Scholar
  16. 16.
    Peeters GM, van Schoor NM, Visser M, Knol DL, Eekhoff EM, de Ronde W et al (2007) Relationship between cortisol and physical performance in older persons. Clin Endocrinol (Oxf) 67(3):398–406CrossRefGoogle Scholar
  17. 17.
    Srikanth VK, Fryer JL, Zhai G, Winzenberg TM, Hosmer D, Jones G (2005) A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis. Osteoarthr Cartil 13(9):769–781PubMedCrossRefGoogle Scholar
  18. 18.
    Zhang Y, Jordan JM (2008) Epidemiology of osteoarthritis. Rheum Dis Clin North Am 34(3):515–529PubMedCrossRefGoogle Scholar
  19. 19.
    Garstang SV, Stitik TP (2006) Osteoarthritis: epidemiology, risk factors, and pathophysiology. Am J Phys Med Rehabil/Assoc Acad Physiatr 85(11 Suppl):S2–11 (quiz S2–4)Google Scholar
  20. 20.
    Stel VS, Smit JH, Pluijm SM, Visser M, Deeg DJ, Lips P (2004) Comparison of the LASA Physical Activity Questionnaire with a 7-day diary and pedometer. J Clin Epidemiol 57(3):252–258PubMedCrossRefGoogle Scholar
  21. 21.
    McDaniel G, Renner JB, Sloane R, Kraus VB (2011) Association of knee and ankle osteoarthritis with physical performance. Osteoarthr Cartil 19(6):634–638PubMedCrossRefGoogle Scholar
  22. 22.
    Murphy TE, Han L, Allore HG, Peduzzi PN, Gill TM, Lin H (2011) Treatment of death in the analysis of longitudinal studies of gerontological outcomes. J Gerontol A Biol Sci Med Sci 66(1):109–114PubMedCrossRefGoogle Scholar
  23. 23.
    Peeters GM, van Schoor NM, Pluijm SM, Deeg DJ, Lips P (2010) Is there a U-shaped association between physical activity and falling in older persons? Osteoporos Int 21(7):1189–1195PubMedCrossRefGoogle Scholar
  24. 24.
    American Geriatrics Society BGS, American Academy of Orthopaedic Surgeons (2001) Guideline for the prevention of falls in older persons. American Geriatrics Society, British Geriatrics Society, and American Academy of Orthopaedic Surgeons Panel on Falls Prevention. J Am Geriatr Soc 49(5):664–72Google Scholar
  25. 25.
    Oksanen T, Kivimaki M, Pentti J, Virtanen M, Klaukka T, Vahtera J (2010) Self-report as an indicator of incident disease. Ann Epidemiol 20(7):547–554PubMedCrossRefGoogle Scholar
  26. 26.
    Simpson CF, Boyd CM, Carlson MC, Griswold ME, Guralnik JM, Fried LP (2004) Agreement between self-report of disease diagnoses and medical record validation in disabled older women: factors that modify agreement. J Am Geriatr Soc 52(1):123–127PubMedCrossRefGoogle Scholar
  27. 27.
    Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33(1):159–174PubMedCrossRefGoogle Scholar
  28. 28.
    Barker K, Lamb SE, Toye F, Jackson S, Barrington S (2004) Association between radiographic joint space narrowing, function, pain and muscle power in severe osteoarthritis of the knee. Clin Rehabil 18(7):793–800PubMedCrossRefGoogle Scholar
  29. 29.
    Bruyere O, Honore A, Rovati LC, Giacovelli G, Henrotin YE, Seidel L et al (2002) Radiologic features poorly predict clinical outcomes in knee osteoarthritis. Scand J Rheumatol 31(1):13–16PubMedCrossRefGoogle Scholar
  30. 30.
    Felson DT, Zhang Y, Hannan MT, Naimark A, Weissman BN, Aliabadi P et al (1995) The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum 38(10):1500–1505PubMedCrossRefGoogle Scholar
  31. 31.
    Oliveria SA, Felson DT, Reed JI, Cirillo PA, Walker AM (1995) Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization. Arthritis Rheum 38(8):1134–1141PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  • Daniël M. van Leeuwen
    • 1
    • 2
    Email author
  • Geeske M. E. E. Peeters
    • 3
  • Cornelis J. de Ruiter
    • 1
  • Paul Lips
    • 4
  • Jos W. R. Twisk
    • 5
    • 6
  • Dorly J. H. Deeg
    • 5
  • Arnold de Haan
    • 1
    • 2
  1. 1.MOVE Research Institute Amsterdam, Faculty of Human Movement SciencesVU University AmsterdamAmsterdamThe Netherlands
  2. 2.Institute for Biomedical Research into Human Movement and HealthManchester Metropolitan UniversityManchesterUK
  3. 3.School of Human Movement StudiesThe University of QueenslandBrisbaneAustralia
  4. 4.Department of Internal Medicine, Endocrine Section, MOVE Research Institute AmsterdamVU University Medical CenterAmsterdamThe Netherlands
  5. 5.Department of Epidemiology and BiostatisticsVU University Medical CenterAmsterdamThe Netherlands
  6. 6.Department of Health SciencesVU University AmsterdamAmsterdamThe Netherlands

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