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Elevated salivary uric acid levels among adolescents with eating disorders

  • Ruth Giesser
  • Tanya Goltser-Dubner
  • Dalya Pevzner
  • Amit Shalev
  • Ranin Masarwa
  • Laura Canetti
  • Ayelet Meltzer
  • Nidal Qutna
  • Roi Ratson
  • Ela Kianski
  • Shikma Keller
  • Esti Galili-Weisstub
  • Ronen SegmanEmail author
Brief Report

Abstract

Objective

Uric acid (UA) is increasingly recognized as having important physiological roles and associated with several peripheral and central pathophysiological outcomes, and might play a role in eating disorders (ED) pathogenesis. We investigated whether UA levels are altered among adolescents with ED.

Methods

Morning salivary UA concentrations were compared between adolescents referred to treatment at the Herman Dana Center receiving a DSM-V diagnosis of an ED and matched healthy controls.

Results

Salivary UA was significantly elevated among ED compared with control values (ED mean 3.9 ± 1.2 mg/dl, control mean 2.9 ± 1.9 mg/dl, t = − 3.13 df = 81, p = 0.003).

Discussion

Salivary UA is elevated among adolescents with ED. Further studies are required to replicate and extend this finding and evaluate its generalizability as a state or trait marker as regards ED subtypes, other body fluids (plasma and cerebrospinal fluid), and recovery or premorbid stages, as well as its putative mechanistic relevance to ED.

Level of Evidence

Level III, case-control analytic study.

Keywords

Salivary uric acid Eating disorder Anorexia nervosa Adolescents Bulimia nervosa 

Notes

Acknowledgements

This work was supported in part by the Herman Dana Foundation.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures involving human participants were approved by the Hadassah Medical Center Ethics Committee Review Board, and performed in accord with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained and forms signed by all individual participants included in the study, and their parents in the case of minors.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ruth Giesser
    • 1
  • Tanya Goltser-Dubner
    • 1
    • 2
  • Dalya Pevzner
    • 1
    • 2
  • Amit Shalev
    • 1
  • Ranin Masarwa
    • 1
  • Laura Canetti
    • 2
  • Ayelet Meltzer
    • 1
  • Nidal Qutna
    • 1
  • Roi Ratson
    • 1
  • Ela Kianski
    • 1
  • Shikma Keller
    • 2
  • Esti Galili-Weisstub
    • 1
  • Ronen Segman
    • 1
    • 2
    Email author
  1. 1.Herman-Dana Division of Child and Adolescent Psychiatry, Department of PsychiatryHadassah - Hebrew University Medical CenterJerusalemIsrael
  2. 2.Molecular Psychiatry Laboratory, Department of PsychiatryHadassah - Hebrew University Medical CenterJerusalemIsrael

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