Elevated salivary uric acid levels among adolescents with eating disorders
Uric acid (UA) is increasingly recognized as having important physiological roles and associated with several peripheral and central pathophysiological outcomes, and might play a role in eating disorders (ED) pathogenesis. We investigated whether UA levels are altered among adolescents with ED.
Morning salivary UA concentrations were compared between adolescents referred to treatment at the Herman Dana Center receiving a DSM-V diagnosis of an ED and matched healthy controls.
Salivary UA was significantly elevated among ED compared with control values (ED mean 3.9 ± 1.2 mg/dl, control mean 2.9 ± 1.9 mg/dl, t = − 3.13 df = 81, p = 0.003).
Salivary UA is elevated among adolescents with ED. Further studies are required to replicate and extend this finding and evaluate its generalizability as a state or trait marker as regards ED subtypes, other body fluids (plasma and cerebrospinal fluid), and recovery or premorbid stages, as well as its putative mechanistic relevance to ED.
Level of Evidence
Level III, case-control analytic study.
KeywordsSalivary uric acid Eating disorder Anorexia nervosa Adolescents Bulimia nervosa
This work was supported in part by the Herman Dana Foundation.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures involving human participants were approved by the Hadassah Medical Center Ethics Committee Review Board, and performed in accord with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Informed consent was obtained and forms signed by all individual participants included in the study, and their parents in the case of minors.
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