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Intimate stimuli result in fronto-parietal activation changes in anorexia nervosa

  • L. van Zutphen
  • S. Maier
  • N. Siep
  • G. A. Jacob
  • O. Tüscher
  • L. Tebartz van Elst
  • A. Zeeck
  • A. Arntz
  • M.-F. O’Connor
  • H. Stamm
  • M. Hudek
  • Andreas JoosEmail author
Original Article

Abstract

Background

Intimacy is a key psychological problem in anorexia nervosa (AN). Empirical evidence, including neurobiological underpinnings, is however, scarce.

Objective

In this study, we evaluated various emotional stimuli including intimate stimuli experienced in patients with AN and non-patients, as well as their cerebral response.

Methods

Functional magnetic resonance imaging was conducted using stimuli with positive, neutral, negative and intimate content. Participants (14 AN patients and 14 non-patients) alternated between passive viewing and explicit emotion regulation.

Results

Intimate stimuli were experienced less positively in AN patients compared to non-patients. AN patients showed decreased cerebral responses in superior parietal cortices in response to positive and intimate stimuli. Intimate stimuli led to stronger activation of the orbitofrontal cortex, and lower activation of the bilateral precuneus in AN patients. Orbitofrontal responses decreased in AN patients during explicit emotion regulation.

Conclusions

These results show that intimate stimuli are of particular importance in AN patients, who show experiential differences compared to non-patients and altered activation of orbitofrontal and parietal brain structures. This supports that AN patients have difficulties with intimacy, attachment, self-referential processing and body perception.

Level of evidence

Level III, case–control study.

Keywords

Anorexia nervosa Intimacy Neuroimaging fMRI Emotion regulation Orbitofrontal cortex Precuneus 

Notes

Acknowledgements

This study was carried out as part of the study DFG (German Research Foundation) JA1785/3-1 and in preparation of DFG-Grant JO 744-2/1.

Funding

Part of project DFG JA1785/3-1.

Compliance with ethical standards

Conflict of interest

There were no potential conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

40519_2017_474_MOESM1_ESM.tif (106 kb)
Supplementary material 1 (TIF 106 KB)
40519_2017_474_MOESM2_ESM.tif (105 kb)
Supplementary material 2 (TIF 105 KB)

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • L. van Zutphen
    • 1
  • S. Maier
    • 2
    • 3
  • N. Siep
    • 1
  • G. A. Jacob
    • 4
  • O. Tüscher
    • 5
  • L. Tebartz van Elst
    • 3
  • A. Zeeck
    • 2
  • A. Arntz
    • 1
    • 6
  • M.-F. O’Connor
    • 7
  • H. Stamm
    • 2
  • M. Hudek
    • 2
  • Andreas Joos
    • 2
    • 8
    Email author
  1. 1.Department of Clinical Psychological ScienceMaastricht UniversityMaastrichtThe Netherlands
  2. 2.Department of Psychosomatic Medicine and Psychotherapy, Medical Center, University of Freiburg Faculty of MedicineUniversity of FreiburgFreiburgGermany
  3. 3.Department of Psychiatry and Psychotherapy, Medical Center, University of Freiburg Faculty of MedicineUniversity of FreiburgFreiburgGermany
  4. 4.Institute of PsychologyUniversity of FreiburgFreiburgGermany
  5. 5.Department of Psychiatry and PsychotherapyUniversity of MainzMainzGermany
  6. 6.Department of Clinical PsychologyUniversity of AmsterdamAmsterdamThe Netherlands
  7. 7.Department of PsychologyUniversity of ArizonaTucsonUSA
  8. 8.Department of Psychotherapeutic NeurologyKliniken Schmieder GailingenGailingenGermany

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