Abstract
Irisin, a novel myokine produced in response to physical activity, promotes white-to-brown fat transdifferentiation. The name irisin referred to the ancient Greek goddess Iris, the messenger who delivered (bad) news from the gods. In mice, it has been demonstrated that irisin plays a key role in metabolic regulation, energy expenditure and glucose homeostasis. New findings from various studies carried out in both animals and humans suggest that irisin might also have other favorable effects, such as increasing bone cortical mass, preventing hepatic lipid accumulation, and improving cognitive functions, thus mediating many exercise-induced health benefits. However, data on the role and function of irisin in humans have prompted controversy, due mostly to the only recent confirmation of the presence of irisin in humans. Another strong limitation to the understanding of irisin mechanisms of action is the lack of knowledge about its receptor, which until now remains unidentified in humans and in animals. This review presents an overall analysis of the history of irisin, its expression, and its involvement in health, especially in humans.
Level of Evidence Level V, review.
Similar content being viewed by others
References
Rosen ED, Spiegelman BM (2014) What we talk about when we talk about fat. Cell 156:20–44. doi:10.1016/j.cell.2013.12.012
Cinti S (2002) Adipocyte differentiation and transdifferentiation: plasticity of the adipose organ. J Endocrinol Invest 25:823–835. doi:10.1007/BF03344046
Pedersen BK, Febbraio MA (2012) Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat Rev Endocrinol 8:457–465. doi:10.1038/nrendo.2012.49
Pedersen BK, Steensberg A, Fischer C, Keller C, Keller P, Plomgaard P, Febbraio M, Saltin B (2003) Searching for the exercise factor: is IL-6 a candidate? J Muscle Res Cell Motil 24:113–119. doi:10.1023/A:1026070911202
Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM (2012) A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481:463–468. doi:10.1038/nature10777
Wrann CD, White JP, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, Lin JD, Greenberg ME, Spiegelman BM (2013) Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. Cell Metab 18:649–659. doi:10.1016/j.cmet.2013.09.008
Colaianni G, Cuscito C, Mongelli T, Pignataro P, Buccoliero C, Liu P, Lu P, Sartini L, Di Comite M, Mori G, Di Benedetto A, Brunetti G, Yuen T, Sun L, Reseland JE, Colucci S, New MI, Zaidi M, Cinti S, Grano M (2015) The myokine irisin increases cortical bone mass. Proc Natl Acad Sci USA 112:12157–121662. doi:10.1073/pnas.1516622112
Jedrychowski MP, Wrann CD, Paulo JA, Gerber KK, Szpyt J, Robinson MM, Nair KS, Gygi SP, Spiegelman BM (2015) Detection and quantitation of circulating human irisin by tandem mass spectrometry. Cell Metab 22:734–740. doi:10.1016/j.cmet.2015.08.001
Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829–839. doi:10.1016/S0092-8674(00)81410-5
Timmons JA, Baar K, Davidsen PK, Atherton PJ (2012) Is irisin a human exercise gene? Nature 488:E9–E10. doi:10.1038/nature11364
Raschke S, Elsen M, Gassenhuber H, Sommerfeld M, Schwahn U, Brockmann B, Jung R, Wisløff U, Tjønna AE, Raastad T, Hallén J, Norheim F, Drevon CA, Romacho T, Eckardt K, Eckel J (2013) Evidence against a beneficial effect of irisin in humans. PLoS One 8:e73680. doi:10.1371/journal.pone.0073680
Ivanov IP, Firth AE, Michel AM, Atkins JF, Baranov PV (2011) Identification of evolutionarily conserved non-AUG-initiated N-terminal extensions in human coding sequences. Nucleic Acids Res 39:4220–4234. doi:10.1093/nar/gkr007
Erickson HP (2013) Irisin and FNDC5 in retrospect: an exercise hormone or a transmembrane receptor? Adipocyte 2:289–293. doi:10.4161/adip.26082
Albrecht E, Norheim F, Thiede B, Holen T, Ohashi T, Schering L, Lee S, Brenmoehl J, Thomas S, Drevon CA, Erickson HP, Maak S (2015) Irisin—a myth rather than an exercise-inducible myokine. Sci Rep 5:8889. doi:10.1038/srep08889
Wen MS, Wang CY, Lin SL, Hung KC (2013) Decrease in irisin in patients with chronic kidney disease. PLoS One 8:e64025. doi:10.1371/journal.pone.0064025
Lee P, Linderman JD, Smith S, Brychta RJ, Wang J, Idelson C, Perron RM, Werner CD, Phan GQ, Kammula US, Kebebew E, Pacak K, Chen KY, Celi FS (2014) Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans. Cell Metab 19:302–309. doi:10.1016/j.cmet.2013.12.017
Schumacher MA, Chinnam N, Ohashi T, Shah RS, Erickson HP (2013) The structure of irisin reveals a novel intersubunit β-sheet fibronectin type III (FNIII) dimer: implications for receptor activation. J Biol Chem 288:33738–33744. doi:10.1074/jbc.M113.516641
Shah R, Ohashi T, Erickson HP, Oas TG (2017) Spontaneous unfolding-refolding of fibronectin type III domains assayed by thiol exchange: thermodynamic stability correlates with rates of unfolding rather than folding. J Biol Chem 292:955–966. doi:10.1074/jbc.M116.760371
Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BE, Mantzoros CS (2012) FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 61:1725–1738. doi:10.1016/j.metabol.2012.09.002
Zhang Y, Li R, Meng Y, Li S, Donelan W, Zhao Y, Qi L, Zhang M, Wang X, Cui T, Yang LJ, Tang D (2014) Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase signaling. Diabetes 63:514–525. doi:10.2337/db13-1106
Zhang Y, Xie C, Wang H, Foss RM, Clare M, George EV, Li S, Katz A, Cheng H, Ding Y, Tang D, Reeves WH, Yang LJ (2016) Irisin exerts dual effects on browning and adipogenesis of human white adipocytes. Am J Physiol Endocrinol Metab 311:E530–E541. doi:10.1152/ajpendo.00094.2016
Kersten S (2014) Integrated physiology and systems biology of PPARα. Mol Metab 3:354–371. doi:10.1016/j.molmet.2014.02.002
Fox J, Rioux BV, Goulet EDB, Johanssen NM, Swift DL, Bouchard DR, Loewen H, Sénéchal M (2017) Effect of an acute exercise bout on immediate post-exercise irisin concentration in adults: a meta-analysis. Scand J Med Sci Sports. doi:10.1111/sms.12904
Dinas PC, Lahart IM, Timmons JA, Svensson PA, Koutedakis Y, Flouris AD, Metsios GS (2017) Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: a systematic review. Version 2. F1000Res 6:286. doi:10.12688/f1000research.11107.2
Miyamoto-Mikami E, Sato K, Kurihara T, Hasegawa N, Fujie S, Fujita S, Sanada K, Hamaoka T, Tabata I, Iemitsu M (2015) Endurance training-induced increase in circulating irisin levels is associated with reduction of abdominal visceral fat in middle-aged and older adults. PLoS One 10:e0120354. doi:10.1371/journal.pone.0120354
Tsuchiya Y, Ando D, Takamatsu K, Goto K (2015) Resistance exercise induces a greater irisin response than endurance exercise. Metabolism 64:1042–1050. doi:10.1016/j.metabol.2015.05.010
Huh JY, Siopi A, Mougios V, Park KH, Mantzoros CS (2015) Irisin in response to exercise in humans with and without metabolic syndrome. J Clin Endocrinol Metab 100:453–457. doi:10.1210/jc.2014-2416
Daskalopoulou SS, Cooke AB, Gomez YH, Mutter AF, Filippaios A, Mesfum ET, Mantzoros CS (2014) Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects. Eur J Endocrinol 171:343–352. doi:10.1530/EJE-14-0204
Norheim F, Langleite TM, Hjorth M, Holen T, Kielland A, Stadheim HK, Gulseth HL, Birkeland KI, Jensen J, Drevon CA (2014) The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans. FEBS J 281:739–749. doi:10.1111/febs.12619
Kurdiova T, Balaz M, Vician M, Maderova D, Vlcek M, Valkovic L, Srbecky M, Imrich R, Kyselovicova O, Belan V, Jelok I, Wolfrum C, Klimes I, Krssak M, Zemkova E, Gasperikova D, Ukropec J, Ukropcova B (2014) Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies. J Physiol 592:1091–1107. doi:10.1113/jphysiol.2013.264655
Hecksteden A, Wegmann M, Steffen A, Kraushaar J, Morsch A, Ruppenthal S, Kaestner L, Meyer T (2013) Irisin and exercise training in humans—results from a randomized controlled training trial. BMC Med 11:235. doi:10.1186/1741-7015-11-235
Roca-Rivada A, Castelao C, Senin LL, Landrove MO, Baltar J, Belén Crujeiras A, Seoane LM, Casanueva FF, Pardo M (2013) FNDC5/irisin is not only a myokine but also an adipokine. PLoS One 8:e60563. doi:10.1371/journal.pone.0060563
Moreno-Navarrete JM, Ortega F, Serrano M, Guerra E, Pardo G, Tinahones F, Ricart W, Fernández-Real JM (2013) Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. J Clin Endocrinol Metab 98:E769–E778. doi:10.1210/jc.2012-2749
Dun SL, Lyu RM, Chen YH, Chang JK, Luo JJ, Dun NJ (2013) Irisin-immunoreactivity in neural and non-neural cells of the rodent. Neuroscience 240:155–162. doi:10.1016/j.neuroscience.2013.02.050
Aydin S, Kuloglu T, Aydin S, Eren MN, Celik A, Yilmaz M, Kalayci M, Sahin I, Gungor O, Gurel A, Ogeturk M, Dabak O (2014) Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: cardiac muscle produces more irisin than skeletal muscle. Peptides 52:68–73. doi:10.1016/j.peptides.2013.11.024
Aydin S, Aydin S, Kuloglu T, Yilmaz M, Kalayci M, Sahin I, Cicek D (2013) Alterations of irisin concentrations in saliva and serum of obese and normal-weight subjects, before and after 45 min of a Turkish bath or running. Peptides 50:13–18. doi:10.1016/j.peptides.2013.09.011
Aydin S, Kuloglu T, Aydin S, Kalayci M, Yilmaz M, Cakmak T, Albayrak S, Gungor S, Colakoglu N, Ozercan IH (2014) A comprehensive immunohistochemical examination of the distribution of the fat-burning protein irisin in biological tissues. Peptides 61:130–136. doi:10.1016/j.peptides.2014.09.014
Ebert T, Focke D, Petroff D, Wurst U, Richter J, Bachmann A, Lössner U, Kralisch S, Kratzsch J, Beige J, Bast I, Anders M, Blüher M, Stumvoll M, Fasshauer M (2014) Serum levels of the myokine irisin in relation to metabolic and renal function. Eur J Endocrinol 170:501–506. doi:10.1530/EJE-13-1053
Lv J, Pan Y, Li X, Cheng D, Ju H, Tian J, Shi H, Zhang Y (2015) Study on the distribution and elimination of the new hormone irisin in vivo: new discoveries regarding irisin. Horm Metab Res 47:591–595. doi:10.1055/s-0035-1547261
Petrovic N, Walden TB, Shabalina IG, Timmons JA, Cannon B, Nedergaard J (2010) Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J Biol Chem 285:7153–7164. doi:10.1074/jbc.M109.053942
Huh JY, Dincer F, Mesfum E, Mantzoros CS (2014) Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans. Int J Obes (Lond) 38:1538–1544. doi:10.1038/ijo.2014.42
Perakakis N, Triantafyllou GA, Fernández-Real JM, Huh JY, Park KH, Seufert J, Mantzoros CS (2017) Physiology and role of irisin in glucose homeostasis. Nat Rev Endocrinol 13:324–337. doi:10.1038/nrendo.2016.221
Polyzos SA, Kountouras J, Anastasilakis AD, Geladari EV, Mantzoros CS (2014) Irisin in patients with nonalcoholic fatty liver disease. Metabolism 63:207–217. doi:10.1016/j.metabol.2013.09.013
Hou N, Han F, Sun X (2015) The relationship between circulating irisin levels and endothelial function in lean and obese subjects. Clin Endocrinol (Oxf) 83:339–343. doi:10.1111/cen.12658
Liu JJ, Wong MD, Toy WC, Tan CS, Liu S, Ng XW, Tavintharan S, Sum CF, Lim SC (2013) Lower circulating irisin is associated with type 2 diabetes mellitus. J Diabetes Complicat 27:365–369. doi:10.1016/j.jdiacomp.2013.03.002
Park KH, Zaichenko L, Brinkoetter M, Thakkar B, Sahin-Efe A, Joung KE, Tsoukas MA, Geladari EV, Huh JY, Dincer F, Davis CR, Crowell JA, Mantzoros CS (2013) Circulating irisin in relation to insulin resistance and the metabolic syndrome. J Clin Endocrinol Metab 98:4899–4907. doi:10.1210/jc.2013-2373
Stengel A, Hofmann T, Goebel-Stengel M, Elbelt U, Kobelt P, Klapp BF (2013) Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity—correlation with body mass index. Peptides 39:125–130. doi:10.1016/j.peptides.2012.11.014
Pardo M, Crujeiras AB, Amil M, Aguera Z, Jiménez-Murcia S, Baños R, Botella C, de la Torre R, Estivill X, Fagundo AB, Fernández-Real JM, Fernández-García JC, Fruhbeck G, Gómez-Ambrosi J, Rodríguez R, Tinahones FJ, Fernández-Aranda F, Casanueva FF (2014) Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index. Int J Endocrinol 2014:857270. doi:10.1155/2014/857270
Sanchis-Gomar F, Alis R, Pareja-Galeano H, Sola E, Victor VM, Rocha M, Hernández-Mijares A, Romagnoli M (2014) Circulating irisin levels are not correlated with BMI, age, and other biological parameters in obese and diabetic patients. Endocrine 46:674–677. doi:10.1007/s12020-014-0170-9
Chen J, Gudson A, Huang Y, Qu S (2015) Irisin: a new molecular marker and target in metabolic disorders. Lipids Health Dis 14:2. doi:10.1186/1476-511X-14-2
García-Fontana B, Reyes-García R, Morales-Santana S, Ávila-Rubio V, Muñoz-Garach A, Rozas-Moreno P, Muñoz-Torres M (2016) Relationship between myostatin and irisin in type 2 diabetes mellitus: a compensatory mechanism to an unfavourable metabolic state? Endocrine 52:54–62. doi:10.1007/s12020-015-0758-8
Al-Daghri NM, Alokail MS, Rahman S, Amer OE, Al-Attas OS, Alfawaz H, Tripathi G, Sabico S, Chrousos GP, McTernan PG, Piya MK (2015) Habitual physical activity is associated with circulating irisin in healthy controls but not in subjects with diabetes mellitus type 2. Eur J Clin Invest 45:775–781. doi:10.1111/eci.12468
Choi YK, Kim MK, Bae KH, Seo HA, Jeong JY, Lee WK, Kim JG, Lee IK, Park KG (2013) Serum irisin levels in new-onset type 2 diabetes. Diabetes Res Clin Pract 100:96–101. doi:10.1016/j.diabres.2013.01.007
Alis R, Sanchis-Gomar F, Pareja-Galeano H, Hernández-Mijares A, Romagnoli M, Víctor VM, Rocha M (2014) Association between irisin and homocysteine in euglycemic and diabetic subjects. Clin Biochem 47:333–335. doi:10.1016/j.clinbiochem.2014.08.017
Khidr EG, Ali SS, Elshafey MM, Fawzy OA (2017) Association of irisin and FNDC5 rs16835198 G > T gene polymorphism with type 2 diabetes mellitus and diabetic nephropathy. An Egyptian pilot study. Gene 626:26–31. doi:10.1016/j.gene.2017.05.010
Sesti G, Andreozzi F, Fiorentino TV, Mannino GC, Sciacqua A, Marini MA, Perticone F (2014) High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects. Acta Diabetol 51:705–713. doi:10.1007/s00592-014-0576-0
Bugianesi E, McCullough AJ, Marchesini G (2005) Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 42:987–1000. doi:10.1002/hep.20920
Bugianesi E, Moscatiello S, Ciaravella MF, Marchesini G (2010) Insulin resistance in nonalcoholic fatty liver disease. Curr Pharm Des 16:1941–1951. doi:10.2174/138161210791208875
Zhang HJ, Zhang XF, Ma ZM, Pan LL, Chen Z, Han HW, Han CK, Zhuang XJ, Lu Y, Li XJ, Yang SY, Li XY (2013) Irisin is inversely associated with intrahepatic triglyceride contents in obese adults. J Hepatol 59:557–562. doi:10.1016/j.jhep.2013.04.030
Park MJ, Kim DI, Choi JH, Heo YR, Park SH (2015) New role of irisin in hepatocytes: the protective effect of hepatic steatosis in vitro. Cell Signal 27:1831–1839. doi:10.1016/j.cellsig.2015.04.010
Choi ES, Kim MK, Song MK, Kim JM, Kim ES, Chung WJ, Park KS, Cho KB, Hwang JS, Jang BK (2014) Association between serum irisin levels and non-alcoholic fatty liver disease in health screen examinees. PLoS One 9:e110680. doi:10.1371/journal.pone.0110680
Petta S, Valenti L, Svegliati-Baroni G, Ruscica M, Pipitone RM, Dongiovanni P, Rychlicki C, Ferri N, Cammà C, Fracanzani AL, Pierantonelli I, Di Marco V, Meroni M, Giordano D, Grimaudo S, Maggioni M, Cabibi D, Fargion S, Craxì A (2017) Fibronectin type III domain-containing protein 5 rs3480 A > G polymorphism, irisin, and liver fibrosis in patients with nonalcoholic fatty liver disease. J Clin Endocrinol Metab. doi:10.1210/jc.2017-00056
Kim HK, Jeong YJ, Song IS, Noh YH, Seo KW, Kim M, Han J (2017) Glucocorticoid receptor positively regulates transcription of FNDC5 in the liver. Sci Rep 7:43296. doi:10.1038/srep43296
Tarantino G, Finelli C (2013) Pathogenesis of hepatic steatosis: the link between hypercortisolism and non-alcoholic fatty liver disease. World J Gastroenterol 19:6735–6743. doi:10.3748/wjg.v19.i40.6735
Hwang YC, Jeon WS, Park CY, Youn BS (2016) The ratio of skeletal muscle mass to visceral fat area is a main determinant linking circulating irisin to metabolic phenotype. Cardiovasc Diabetol 15:9. doi:10.1186/s12933-015-0319-8
Halcox JP, Schenke WH, Zalos G, Mincemoyer R, Prasad A, Waclawiw MA, Nour KR, Quyyumi AA (2002) Prognostic value of coronary vascular endothelial dysfunction. Circulation 106:653–658. doi:10.1161/01.CIR.0000025404.78001.D8
Brevetti G, Silvestro A, Schiano V, Chiariello M (2003) Endothelial dysfunction and cardiovascular risk prediction in peripheral arterial disease: additive value of flow-mediated dilation to ankle-brachial pressure index. Circulation 108:2093–2098. doi:10.1161/01.CIR.0000095273.92468.D9
Shechter M, Issachar A, Marai I, Koren-Morag N, Freinark D, Shahar Y, Shechter A, Feinberg MS (2009) Long-term association of brachial artery flow-mediated vasodilation and cardiovascular events in middle-aged subjects with no apparent heart disease. Int J Cardiol 134:52–58. doi:10.1016/j.ijcard.2008.01.021
Aronis KN, Moreno M, Polyzos SA, Moreno-Navarrete JM, Ricart W, Delgado E, de la Hera J, Sahin-Efe A, Chamberland JP, Berman R, Spiro A, Vokonas P, Fernández-Real JM, Mantzoros CS (2015) Circulating irisin levels and coronary heart disease: association with future acute coronary syndrome and major adverse cardiovascular events. Int J Obes (Lond) 39:156–161. doi:10.1038/ijo.2014.101
Kuloglu T, Aydin S, Eren MN, Yilmaz M, Sahin I, Kalayci M, Sarman E, Kaya N, Yilmaz OF, Turk A, Aydin Y, Yalcin MH, Uras N, Gurel A, Ilhan S, Gul E, Aydin S (2014) Irisin: a potentially candidate marker for myocardial infarction. Peptides 55:85–91. doi:10.1016/j.peptides.2014.02.008
Aydin S, Aydin S, Kobat MA, Kalayci M, Eren MN, Yilmaz M, Kuloglu T, Gul E, Secen O, Alatas OD, Baydas A (2014) Decreased saliva/serum irisin concentrations in the acute myocardial infarction promising for being a new candidate biomarker for diagnosis of this pathology. Peptides 56:141–145. doi:10.1016/j.peptides.2014.04.002
Polak JF, Pencina MJ, Pencina KM, O’Donnell CJ, Wolf PA, D’Agostino RB Sr (2011) Carotid-wall intima-media thickness and cardiovascular events. N Engl J Med 365:213–221. doi:10.1056/NEJMoa1012592
Rana KS, Arif M, Hill EJ, Aldred S, Nagel DA, Nevill A, Randeva HS, Bailey CJ, Bellary S, Brown JE (2014) Plasma irisin levels predict telomere length in healthy adults. Age (Dordr) 36:995–1001. doi:10.1007/s11357-014-9620-9
Brouilette S, Singh RK, Thompson JR, Goodall AH, Samani NJ (2003) White cell telomere length and risk of premature myocardial infarction. Arterioscler Thromb Vasc Biol 23:842–846. doi:10.1161/01.ATV.0000067426.96344.32
Oelmann S, Nauck M, Völzke H, Bahls M, Friedrich N (2016) Circulating irisin concentrations are associated with a favourable lipid profile in the general population. PLoS One 11:e0154319. doi:10.1371/journal.pone.0154319
Boushey CJ, Beresford SA, Omenn GS, Motulsky AG (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA 274:1049–1057. doi:10.1001/jama.1995.03530130055028
Homocysteine Studies Collaboration (2002) Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. JAMA 288:2015–2022. doi:10.1001/jama.288.16.2015
Polyzos SA, Kountouras J, Anastasilakis AD, Margouta A, Mantzoros CS (2015) Association between circulating irisin and homocysteine in patients with nonalcoholic fatty liver disease. Endocrine 49:560–562. doi:10.1007/s12020-014-0473-x
Mazur-Bialy AI, Pocheć E, Zarawski M (2017) Anti-inflammatory properties of irisin, mediator of physical activity, are connected with TLR4/MyD88 signaling pathway activation. Int J Mol Sci 18:E701. doi:10.3390/ijms18040701
Mazur-Bialy AI, Bilski J, Pochec E, Brzozowski T (2017) New insight into the direct anti-inflammatory activity of a myokine irisin against proinflammatory activation of adipocytes. Implication for exercise in obesity. J Physiol Pharmacol 68:243–251
Shao L, Meng D, Yang F, Song H, Tang D (2017) Irisin-mediated protective effect on LPS-induced acute lung injury via suppressing inflammation and apoptosis of alveolar epithelial cells. Biochem Biophys Res Commun 487:194–200. doi:10.1016/j.bbrc.2017.04.020
Mazur-Bialy AI (2017) Irisin acts as a regulator of macrophages host defense. Life Sci 176:21–25. doi:10.1016/j.lfs.2017.03.011
Liu S, Du F, Li X, Wang M, Duan R, Zhang J, Wu Y, Zhang Q (2017) Effects and underlying mechanisms of irisin on the proliferation and apoptosis of pancreatic β cells. PLoS One 12:e0175498. doi:10.1371/journal.pone.0175498
Colaianni G, Mongelli T, Cuscito C, Pignataro P, Lippo L, Spiro G, Notarnicola A, Severi I, Passeri G, Mori G, Brunetti G, Moretti B, Tarantino U, Colucci SC, Reseland JE, Vettor R, Cinti S, Grano M (2017) Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice. Sci Rep 7:2811. doi:10.1038/s41598-017-02557-8
Colaianni G, Cuscito C, Mongelli T, Oranger A, Mori G, Brunetti G, Colucci S, Cinti S, Grano M (2014) Irisin enhances osteoblast differentiation in vitro. Int J Endocrinol 2014:902186. doi:10.1155/2014/902186
Belviranli M, Okudan N, Kabak B, Erdoğan M, Karanfilci M (2016) The relationship between brain-derived neurotrophic factor, irisin and cognitive skills of endurance athletes. Phys Sportsmed 44:290–296. doi:10.1080/00913847.2016.1196125
Samy DM, Ismail CA, Nassra RA (2015) Circulating irisin concentrations in rat models of thyroid dysfunction—effect of exercise. Metabolism 64:804–813. doi:10.1016/j.metabol.2015.01.001
Ruchala M, Zybek A, Szczepanek-Parulska E (2014) Serum irisin levels and thyroid function—newly discovered association. Peptides 60:51–55. doi:10.1016/j.peptides.2014.07.021
Yalcin MM, Akturk M, Tohma Y, Cerit ET, Altinova AE, Arslan E, Yetkin I, Toruner FB (2016) Irisin and myostatin levels in patients with Graves’ disease. Arch Med Res 47:471–475. doi:10.1016/j.arcmed.2016.11.002
Panagiotou G, Pazaitou-Panayiotou K, Paschou SA, Komninou D, Kalogeris N, Vryonidou A, Mantzoros CS (2016) Changes in thyroid hormone levels within the normal and/or subclinical hyper- or hypothyroid range do not affect circulating irisin levels in humans. Thyroid 26:1039–1045. doi:10.1089/thy.2016.0098
Cannon B, Nedergaard J (2004) Brown adipose tissue: function and physiological significance. Physiol Rev 84:277–359. doi:10.1152/physrev.00015.2003
Eddy SF, Morin P Jr, Storey KB (2005) Cloning and expression of PPAR-gamma and PGC-1alpha from the hibernating ground squirrel, Spermophilus tridecemlineatus. Mol Cell Biochem 269:175–182
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
On behalf of all authors, the corresponding author states that there is no conflict of interest.
Ethical approval
This article does not contain any studies with human participants or animals performed by any of the authors.
Informed consent
For this type of study, formal consent is not required.
Rights and permissions
About this article
Cite this article
Buscemi, S., Corleo, D., Buscemi, C. et al. Does iris(in) bring bad news or good news?. Eat Weight Disord 23, 431–442 (2018). https://doi.org/10.1007/s40519-017-0431-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s40519-017-0431-8