Impact of somatic severity on long-term mortality in anorexia nervosa
Anorexia nervosa (AN) is a severe pathology on account of the high levels of associated morbidity and mortality. This study aimed to assess whether time in somatic intensive care unit, justified by a patient’s somatic condition in the course of hospital care, has any relationship with patient outcome in terms of mortality in the long term.
195 patients were hospitalised for AN between April 1996 and May 2002, 97 were re-assessed 9 years later on average.
Out of 195 patients hospitalised for AN between April 1996 and May 2002, 29 had required transfer to intensive care. Mortality at 9 years was 20 times higher in the group having been transferred to intensive care, irrespective of the duration of follow-up.
The clinical seriousness of the somatic condition during hospitalisation for AN is a risk factor for excess mortality in the medium term.
KeywordsAnorexia nervosa Intensive care unit Follow-up Mortality
Compliance with ethical standards
Source of funding
Fondation de France; Fondation PFIZER.
Conflict of interest
All authors declare that they have no conflict of interests.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the Direction Générale de la Santé (French health authority) July 22nd 2007, the Comité Consultatif des Personnes se prêtant à la Recherche Biomédicale (biomedical research committee), April 24th 2007, the French Committee for personal freedoms (CNIL), October 30th 2007, and an independent review board (CCTIRS, Comité Consultatif sur le Traitement de l’Information en matière de Recherche dans le domaine de la Santé.
Informed consent was obtained from all individual participants included in the study.
- 8.Huas C, Caille A, Godart N, Foulon C, Pham-Scottez A, Divac S, Dechartres A, Lavoisy G, Guelfi JD, Rouillon F, Falissard B (2011) Factors predictive of ten-year mortality in severe anorexia nervosa patients. Acta Psychiatr Scand 123(1):62–70. doi: 10.1111/j.1600-0447.2010.01627.x CrossRefPubMedGoogle Scholar
- 16.Hebebrand J, Himmelmann GW, Heseker H, Schafer H, Remschmidt H (1996) Use of percentiles for the body mass index in anorexia nervosa: diagnostic, epidemiological, and therapeutic considerations. Int J Eat Disord 19(4):359–369. doi: 10.1002/(SICI)1098-108X(199605)19:4<359:AID-EAT4>3.0.CO;2-K CrossRefGoogle Scholar
- 19.Godart N, Wallier J, Hubert T, Curt F, Gales O, Perdereau F, Agman G, Jeammet P (2009) Detemining factors for target weights in an anorexia nervosa inpatient program for adolescents and young adults: study on the links between theory-based hypotheses and the realities of clinical practice. Eat Weight Disord 14(4):e176–e183CrossRefGoogle Scholar
- 21.HAS (2010) Anorexie mentale: prise en charge. Recommandations pour la pratique clinique. https://www.has-sante.fr
- 26.Hebebrand J, Himmelmann GW, Herzog W, Herpertz-Dahlmann BM, Steinhausen HC, Amstein M, Seidel R, Deter HC, Remschmidt H, Schafer H (1997) Prediction of low body weight at long-term follow-up in acute anorexia nervosa by low body weight at referral. Am J Psychiatry 154(4):566–569CrossRefGoogle Scholar