Beverage consumption and paediatric NAFLD

  • Antonella Mosca
  • Claudia Della Corte
  • Maria Rita Sartorelli
  • Francesca Ferretti
  • Francesco Nicita
  • Andrea Vania
  • Valerio Nobili


Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children and adolescents, due to the increased worldwide incidence of obesity among children. It is now clear enough that of diet high in carbohydrates and simple sugars are associated with hepatic steatosis and non-alcoholic steatohepatitis (NASH). Several studies have shown that an increased consumption of simple sugars is also positively associated with overweight and obesity, and related co-morbidities, such as type 2 diabetes, metabolic syndrome and NAFLD. It is difficult to define the role of the various components of soft drinks and energy drinks in the pathogenesis of NAFLD and its progression in NASH, but the major role is played by high calorie and high sugar consumption, mainly fructose. In addition, other components of these beverages (e.g. xanthine) seem to have an important role in the pathogenesis of metabolic disorders, crucial pathways involved in NAFLD/NASH. The drastic reduction in the consumption of energy drinks and soft drinks is an appropriate intervention for the prevention of obesity and NAFLD in young people.


NAFLD Adolescents Soft drinks Energy drinks Fructose Alcohol 


Compliance with ethical standards

Financial support statement

This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

Conflict of interest

All Authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

Ethical approval

In all cited studies, all applicable international, national, and/or institutional guidelines for the care and use of animals were followed and all procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the cited studies.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Antonella Mosca
    • 2
  • Claudia Della Corte
    • 1
  • Maria Rita Sartorelli
    • 1
  • Francesca Ferretti
    • 1
  • Francesco Nicita
    • 3
  • Andrea Vania
    • 2
  • Valerio Nobili
    • 1
  1. 1.Hepato-Metabolic Disease UnitBambino Gesù Children’s Hospital, IRCCSRomeItaly
  2. 2.Department of Paediatrics and Paediatric Neuropsychiatry, Centre of Paediatric Dietetics and NutritionSapienza UniversityRomeItaly
  3. 3.Child Neurology Unit, Department of Paediatrics and Paediatric NeuropsychiatrySapienza UniversityRomeItaly

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