Metabolic profile and psychological variables after bariatric surgery: association with weight outcomes

  • Isabel Brandão
  • Sofia Ramalho
  • Ana Pinto-Bastos
  • Filipa Arrojado
  • Gil Faria
  • Conceição Calhau
  • Rui Coelho
  • Eva Conceição
Original Article



This study aims to examine associations between metabolic profile and psychological variables in post-bariatric patients and to investigate if metabolic and psychological variables, namely high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), glycated hemoglobin (HbA 1c), impulsivity, psychological distress, depressive and eating disorder symptoms are independently associated with percentage of excess weight loss (%EWL) after bariatric surgery.


One hundred and fifty bariatric patients (BMI = 33.04 ± 5.8 kg/m2) who underwent to bariatric surgery for more than 28.63 ± 4.9 months were assessed through a clinical interview, a set of self-report measures and venous blood samples. Pearson’s correlations were used to assess correlations between %EWL, metabolic and psychological variables. Multiple linear regression was conducted to investigate which metabolic and psychological variables were independently associated with %EWL, while controlling for type of surgery.


Higher TG blood levels were associated with higher disordered eating, psychological distress and depression scores. HDL-C was associated with higher depression scores. Both metabolic and psychological variables were associated with %EWL. Regression analyses showed that, controlling for type of surgery, higher % EWL is significantly and independently associated with less disordered eating symptoms and lower TG and HbA_1c blood concentrations (R2 aj = 0.383, F (4, 82) = 14.34, p < 0.000).


An association between metabolic and psychological variables, particularly concerning TG blood levels, disordered eating and psychological distress/depression was found. Only higher levels of disordered eating, TG and HbA_1c showed and independent correlation with less weight loss. Targeting maladaptive eating behaviors may be a reasonable strategy to avoid weight regain and optimize health status post-operatively.


Bariatric surgery Eating behavior Depression Metabolic profile Type 2 diabetes mellitus 


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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  • Isabel Brandão
    • 1
  • Sofia Ramalho
    • 2
  • Ana Pinto-Bastos
    • 2
  • Filipa Arrojado
    • 1
    • 2
  • Gil Faria
    • 3
    • 4
  • Conceição Calhau
    • 4
    • 5
  • Rui Coelho
    • 1
  • Eva Conceição
    • 2
  1. 1.Faculty of MedicineUniversity of Porto, Hospital de São JoãoPortoPortugal
  2. 2.University of Minho, School of PsychologyBragaPortugal
  3. 3.CINTESIS-Center for Research in Health Technologies and Information SystemsPortoPortugal
  4. 4.Department of General SurgeryOporto Hospital CenterPortoPortugal
  5. 5.Department of Biochemistry, Faculty of MedicineUniversity of Porto, Centro de Investigação MédicaPortoPortugal

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