The Gastrointestinal Microbiome in Chronic Renal Diseases

  • Mark A. Bryniarski
  • Sarah E. M. Hoffman
  • Rabi YacoubEmail author
Host Parasite Interactions in Periodontal Disease (C Genco and D Kinane, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Host Parasite Interactions in Periodontal Disease
  2. Topical Collection on Host Parasite Interactions in Periodontal Disease


Purpose of Review

The relationship between microorganisms within the gastrointestinal tract and the renal function of the host is reciprocal. The objective of the current review is therefore twofold. First, we aim to demonstrate the emerging role of gastrointestinal microbiome dysbiosis in the pathogenesis and progression of chronic kidney disease. Second, we highlight specific mechanisms as to how microbiome dysbiosis is provoked in chronic kidney disease.

Recent Findings

Current work has shown that microbiome dysbiosis can directly and indirectly influence renal physiology and contribute to the onset and development of chronic kidney disease, such as by stimulating hypertension. It is also becoming evident that the composition and function of both the intestinal and oral microbiomes are adversely impacted by chronic kidney disease, which can further exacerbate dysbiosis.


This review discusses the current knowledge on the associations between the gastrointestinal microbiome and renal health, to which Dr. Robert Genco has contributed substantially. As we mourn his loss, we celebrate his lifelong dedication to the advancement of research at the University at Buffalo and the microbiome research community worldwide.


Microbiome Chronic kidney disease Dysbiosis 


Funding Information

This work was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health (NIH) under award number UL1-TR-001412 to the Univ. at Buffalo and by the NIH. This work was also supported by the University at Buffalo Genome, Environment and Microbiome.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any primary research studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Mark A. Bryniarski
    • 1
  • Sarah E. M. Hoffman
    • 2
  • Rabi Yacoub
    • 3
    Email author
  1. 1.Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical SciencesUniversity at BuffaloBuffaloUSA
  2. 2.Department of Anthropology, College of Arts and SciencesUniversity at BuffaloBuffaloUSA
  3. 3.Department of Internal Medicine, Jacobs School of Medicine and Biomedical SciencesUniversity at BuffaloBuffaloUSA

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