Current Oral Health Reports

, Volume 5, Issue 4, pp 242–249 | Cite as

Saliva – A Promising Tool for Diagnosing Oral Diseases

  • David T. Wu
  • Owen Tao
  • Nathalie Trinh
  • Mohammad A. Javaid
  • Ahad S. Ahmed
  • Robert Durand
  • Simon D. TranEmail author
Epidemiology (M Laine, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Epidemiology


Purpose of Review

This review will present updates on the genome, transcriptome, proteome, metabolome, exosome, and microbiome of saliva and the wide range of biomarkers found within these salivary components. We will explore the effectiveness and potential of salivary diagnostics on specific diseases: dental caries and demineralization diseases, periodontal diseases and peri-implantitis, oral cancers, and Sjögren’s syndrome.

Recent Findings

Recent studies have shown the feasibility of saliva as a diagnostic tool, in addition to the emergence of many novel salivary biomarkers. Unfortunately, many of these studies do not explore further into the outcomes of patient-oriented health and do not demonstrate reliability in diverse patient populations.


Salivary diagnostics is an emerging field that uses saliva, for its non-invasive, fast, and cost-effective collection properties, as a diagnostic tool. In the near future, we expect that salivary diagnostics will benefit from technological advances and further studies to be used as a routine chair-side test included in a comprehensive diagnostic and risk assessment tool.


Saliva Diagnostics Salivaomics Dental caries Periodontal disease Oral cancer 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • David T. Wu
    • 1
  • Owen Tao
    • 1
  • Nathalie Trinh
    • 1
  • Mohammad A. Javaid
    • 2
  • Ahad S. Ahmed
    • 3
  • Robert Durand
    • 4
  • Simon D. Tran
    • 1
    Email author
  1. 1.Craniofacial Tissue Engineering and Stem Cells Laboratory, Faculty of DentistryMcGill UniversityMontrealCanada
  2. 2.Graduate Periodontics, School of Dentistry, Faculty of Medicine and DentistryUniversity of AlbertaEdmontonCanada
  3. 3.Henry M. Goldman School of Dental MedicineBoston UniversityBostonUSA
  4. 4.Division of Periodontics, Faculty of DentistryUniversité de MontréalMontrealCanada

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