Growth Factors and Cell Homing in Dental Tissue Regeneration
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Purpose of Review
To summarize current views on the role and therapeutic potential of growth factors (GFs) within endodontic cell homing.
Cell homing/revitalization techniques aim to regenerate dentin and pulp using endogenous cells. Clinically, revitalization has successfully created new vital tissue in necrotic permanent teeth with an open apex; however, there is no evidence of new odontoblasts, pulp tissue, or predictable extension in root length. Although the response is reparative rather than regenerative, exciting opportunities to improve these biologically-based strategies remain by (1) efficiently sequestering dentin-matrix-components (DMCs) using irrigants and dental materials (2) designing next-generation GF-releasing scaffold materials and (3) utilizing other sources of GF such as cells and plasma-rich plasma and plasma-rich fibrin.
GFs can promote reparative-dentinogenesis and pulp-like tissue formation. The future development and clinical approval of GF-functionalized-scaffolds is a priority; however, current focus should be to harness DMCs and target the interaction of stem cells and GFs.
KeywordsCell homing Dental pulp stem cell Regenerative endodontics Dentin-pulp complex Growth factors Functionalized scaffolds
Work in Dr. Emi Shimizu’s lab is supported by a grant from the National Institutes of Dental and Craniofacial Research (NIDCR) R01-DE025885.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
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