Current Oral Health Reports

, Volume 5, Issue 2, pp 108–115 | Cite as

Periodontal Host Response in Subjects with Obesity

  • Hideaki Hayashida
  • Reiko FurugenEmail author
  • Toshiyuki Saito
Oral Disease and Nutrition (F Nishimura, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Oral Disease and Nutrition


Purpose of Review

This review focuses on recent advances in understanding the periodontal host response in obese subjects.

Recent Findings

Increased pro-inflammatory adipokines such as leptin, progranulin, resistin, and visfatin and decreased anti-inflammatory adipokines such as adiponectin, exacerbated inflammatory response, alveolar bone resorption, and inhibition of tissue regeneration have been observed in the periodontal tissue in obese subjects. Elevated oxidative stress also affects progression of periodontitis. Obesity may affect the expression of microRNAs related to inflammatory and metabolic mRNA targets in periodontal tissue.


Although obesity may promote the progression of periodontitis in multiple manners, additional studies are needed to clarify the periodontal host response in obesity.


Periodontal host response Obesity Adipokine Oxidative stress MicroRNA 


Compliance with Ethics Standards

Conflict of Interest

All authors declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance, •• Of major importance

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Hideaki Hayashida
    • 1
  • Reiko Furugen
    • 1
    Email author
  • Toshiyuki Saito
    • 1
  1. 1.Department of Oral Health, Unit of Social Medicine, Graduate School of Biomedical SciencesNagasaki UniversityNagasakiJapan

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