Current Oral Health Reports

, Volume 5, Issue 2, pp 89–95 | Cite as

Vitamin Status and Mineralized Tissue Development

  • Kimie Nakagawa
  • Yumi Okubo
  • Ritsuko MasuyamaEmail author
Oral Disease and Nutrition (F Nishimura, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Oral Disease and Nutrition


Purpose of Review

The physiological control of mineralized tissue development is mediated by two processes: mineralization, such as bone formation due to osteoblast activity, and mineralized tissue destruction by osteoclast bone resorption. In this system, nutritional status, including vitamin intake, influences each regulatory processes, although definite responding mechanisms in target cells vary according to each compound.

Recent Findings

In contrast with water-soluble vitamins that constant supply is required, fat-soluble vitamins such as vitamin D and K are stored in the liver and fat tissue for long time. They are metabolized into congeneric compounds with various activities to participate in the local mineralization process in the body.


During physiological or non-physiological mineralization, the local actions of vitamin D and K are regulated by nutrient factor derived from dietary supply, and influenced by systemic calcium metabolism and homeostasis.


Calcium absorption Bone mineralization Elastic fiber calcification 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance, •• Of major importance

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Hygienic SciencesKobe Pharmaceutical UniversityKobeJapan
  2. 2.Department of DermatologyNagasaki University Graduate School of Biomedical SciencesNagasakiJapan
  3. 3.Research and Clinical Center for Yusho and Dioxin (ReC2YD)Kyushu University HospitalFukuokaJapan
  4. 4.Department of Molecular Bone BiologyNagasaki University Graduate School of Biomedical SciencesNagasakiJapan

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