Current Oral Health Reports

, Volume 5, Issue 1, pp 26–32 | Cite as

Periodontal Disease and Osteoporosis-Shared Risk Factors and Potentiation of Pathogenic Mechanisms

  • Maria Bernal
  • Martina Elenkova
  • Josh Evensky
  • Sidney H. SteinEmail author
Systemic Diseases (N Buduneli, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Systemic Diseases


Purpose of Review

Periodontitis and osteoporosis are diseases which exhibit bone loss, quantifiable in the oral cavity and skeleton respectively. Accumulating evidence suggests that the two diseases interact with each other resulting in increased prevalence and more rapid disease progression. This review will explore if recent publications can elucidate the mechanisms by which this occurs.

Recent Studies

Animal studies suggested that osteoporosis will accelerate the progression and severity of periodontitis. Most human studies have supported this association, mainly based upon radiographic measurements and to a lesser extent on clinical findings. They share several risk factors including age, genetics, hormonal changes, smoking, and calcium and vitamin D deficiency. Intriguingly, therapy aimed at one disease may have a positive impact upon the other disease.


This review examined recent literature and found evidence of a bidirectional relationship which facilitates communication in subjects diagnosed with periodontitis and osteoporosis promoting disease severity.


Periodontitis Osteoporosis Risk factors Disease progression 


Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Maria Bernal
    • 1
  • Martina Elenkova
    • 1
  • Josh Evensky
    • 1
  • Sidney H. Stein
    • 1
    Email author
  1. 1.Department of Periodontology, College of DentistryUniversity of Tennessee Health Science CenterMemphisUSA

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