Current Oral Health Reports

, Volume 3, Issue 4, pp 314–318 | Cite as

Feasibility of Periodontal Tissue Regeneration Therapy with Adipose-Derived Stem Cells

  • Morikuni TobitaEmail author
Orodental Regenerative Medicine (M Bartold, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Orodental Regenerative Medicine


Adipose-derived stem cells within subcutaneous adipose tissue were first reported in 2001. Since then, the number of regenerative medicine studies investigating adipose-derived stem cells (ASCs) has increased dramatically. This has included not only basic research in regenerative medicine using ASCs but also has progressed and clinical safety studies have now commenced in Japan. Translational research (including clinical research and clinical trials) using cell therapy aims to verify the possibility of achieving repair of tissue or its function and investigating the safety of these protocols. However, despite this simplicity, elucidating the mechanism of action of implanted processed cells is difficult. This indicates the necessity for the further discussion focusing on translational research for cell therapy, as well as continuing to develop novel therapeutic strategies. In this paper, we discuss the feasibility of practical application of using ASCs for periodontal tissue regeneration therapy and discuss the legal system for promoting the practical application of regenerative medicine recently enforced in Japan.


Adipose-derived stem cells Research development Periodontal tissue regeneration Act on the safety of regenerative medicine Clinical research Translational research 


Compliance with Ethical Standards

Conflict of Interest

Morikuni Tobita declares that he has no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by author.


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Copyright information

© Springer International Publishing AG 2016

Authors and Affiliations

  1. 1.Department of Plastic and Reconstructive SurgeryJuntendo University School of MedicineTokyoJapan

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