Current Oral Health Reports

, Volume 3, Issue 2, pp 74–81 | Cite as

Immunotherapy for Head and Neck Squamous Cell Carcinoma

  • Rebecca C. Hoesli
  • Jeffrey S. MoyerEmail author
Oral Neoplasia (F Alawi and A Le, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Oral Neoplasia


Head and neck squamous cell carcinoma has been found to be an immunosuppressive malignancy, with many defects in the host immune system contributing to the progression of disease. A greater understanding of these defects has lead to the identification and investigation of new therapeutic strategies, targeting immune system dysfunction in an effort to improve the outcomes of this disease. This article provides a brief review of the knowledge regarding the immune defects present in head and neck cancer, as well as a review of the current therapeutic strategies being investigated for use.


Immunology Squamous cell carcinoma Head and neck cancer 


Compliance with Ethical Standards

Conflict of Interest

Rebecca C. Hoesli and Jeffrey S. Moyer declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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© Springer International Publishing AG 2016

Authors and Affiliations

  1. 1.Department of Otolaryngology-Head and Neck SurgeryUniversity of Michigan Comprehensive Cancer CenterAnn ArborUSA

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