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Focusing on the Pharmacological Effects of Iridoids and Crocetin and Its Ester Derivatives of Gardenia jasminoides

  • Meiyan Wang
  • Shiming LiEmail author
  • Klaus W. Lange
  • Hui ZhaoEmail author
Natural Products: From Chemistry to Pharmacology (C Ho, Section Editor)
  • 12 Downloads
Part of the following topical collections:
  1. Topical Collection on Natural Products: From Chemistry to Pharmacology

Abstract

Gardenia jasminoides (G. jasminoides), grown in multiple regions in China, was commonly used as a natural yellow dye but has been one of the popular traditional Chinese medicines since the discovery of its biological property few decades ago. It has been reported that G. jasminoides possesses multiple bioactivities, such as anti-oxidant property, hypoglycemic effect, and inhibition of inflammation, anti-depression, and improving sleeping quality. In this review, we aimed to have a comprehensive summary of its phytochemistry including the extraction, isolation, and characterization of volatiles and bioactive molecules in G. jasminoides, focusing on the two major phytochemicals, iridoids and crocetin, and its ester derivatives, which exhibit potential medicinal properties. Furthermore, this work attempted to establish a structure activity relationship (SAR) between the two major series of derivatives with different molecular skeletons and their biological activities, which would serve further exploration of the health-promoting potentials of phyto-compounds in G. jasminoides as dietary supplements or functional ingredients in medical foods.

Graphical Abstract

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Keywords

Gardenia jasminoides Iridoid Genipin Geniposide Crocin Crocetin 

Notes

Funding Information

This contribution was supported by the National Natural Science Foundation of China [grant numbers 31571832 and 81803548], Tianjin Key Laboratory of Food Biotechnology [grant number TJCU-KLFB-18201], and Tianjin Innovative Research Team Grant [grant number TD13-5087].

Compliance with Ethical Standards

Conflict of Interest

The authors declare no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. 1.Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food ScienceTianjin University of CommerceTianjinPeople’s Republic of China
  2. 2.Hubei Key Laboratory of EFGIRHuanggang Normal UniversityHuanggangChina
  3. 3.Department of Food ScienceRutgers UniversityNew BrunswickUSA
  4. 4.Department of Experimental PsychologyUniversity of RegensburgRegensburgGermany

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