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Mantle cell lymphoma: from ultrasound examination to histological diagnosis

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Abstract

We report the case of a 42-year-old patient referred to our department for the examination of two large, symmetrical inguinal lumps. The ultrasound examination of the swollen lymph node demonstrated a cortical echogenicity greater than the medullary echogenicity, and the vascularization stop around the cortical zone suggested a pathological pattern of mantle cell lymphoma. In this type of lymphoma, lymphocytes are localized in a mantle zone, inducing a thickening of the lumps. Therefore, for the first time, ultrasound examination detected sonographic vascular features of mantle cell lymphoma, allowing the identification of the disease and suggesting the specific histological diagnosis.

Sommario

Riportiamo il caso di una paziente di 42 anni giunta alla nostra osservazione per il riscontro di due grossi linfonodi inguinali simmetrici. L’esame ecografico del linfonodo ingrossato ha mostrato una ecogenicità corticale maggiore di quella midollare, e il blocco della vascolarizzazione attorno alla zona corticale ha evidenziato un pattern patologico suggestivo di linfoma a cellule mantellari. In questo tipo di linfoma, i linfociti sono localizzati in una zona del mantello, inducendo un ispessimento dei linfonodi. Pertanto, per la prima volta in letteratura, l’esame ecografico ha rilevato delle caratteristiche vascolari ecografiche di linfoma a cellule mantellari, consentendo l’identificazione della malattia e suggerendo la diagnosi istologica specifica.

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This study was not funded.

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Authors and Affiliations

  1. Unit of Internistic Ultrasound, Department of Medicine and Science of Aging, G. D’Annunzio University, Cesi-Met, via Luigi Polacchi, 66100, Chieti, CH, Italy

    G. Cocco, A. Boccatonda, D. D’Ardes & C. Schiavone

  2. Musculoskeletal Ultrasound School, Italian Society for Ultrasound in Medicine and Biology (SIUMB), Bologna, Italy

    S. Galletti

Authors
  1. G. Cocco
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  2. A. Boccatonda
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  3. D. D’Ardes
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  4. S. Galletti
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  5. C. Schiavone
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Correspondence to A. Boccatonda.

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The authors declare that they have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Informed consent was obtained from all individual participants included in the study.

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Cocco, G., Boccatonda, A., D’Ardes, D. et al. Mantle cell lymphoma: from ultrasound examination to histological diagnosis. J Ultrasound 21, 339–342 (2018). https://doi.org/10.1007/s40477-018-0318-1

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  • DOI: https://doi.org/10.1007/s40477-018-0318-1

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