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Current Behavioral Neuroscience Reports

, Volume 5, Issue 4, pp 310–318 | Cite as

Cognitive Functioning in Late-life Depression: A Critical Review of Sociodemographic, Neurobiological, and Treatment Correlates

  • Vonetta M. Dotson
  • Sarah M. Szymkowicz
  • Joseph U. Kim
  • Shawn M. McClintock
Geropsychiatry & Cognitive Disorders of Late Life (P Newhouse, Section Editor)
  • 43 Downloads
Part of the following topical collections:
  1. Topical Collection on Geropsychiatry & Cognitive Disorders of Late Life

Abstract

Purpose of Review

Both clinical and subthreshold depression in older adults are associated with cognitive dysfunction. This review summarizes the latest literature on patterns of cognitive functioning in late-life depression (LLD), including moderators of the relationship between depression and cognitive functioning and underlying neurobiological mechanisms.

Recent Findings

LLD is associated with cognitive dysfunction across multiple domains, particularly processing speed and executive functions. This relationship is moderated by demographic and clinical variables such as sex, race, age of onset, and severity of different symptom dimensions of depression. The impact of depression treatment on cognitive deficits in LLD differs across treatment approaches, but overall LLD is associated with persistent cognitive deficits after depression remission.

Summary

Clarifying treatments with dual mood and cognitive benefits is an important area for future research. Our understanding of and treatment for cognitive deficits in LLD will also benefit from additional work that examines clinical and demographic contributions.

Keywords

Geriatric depression Cognitive impairment Older adults Cognitive decline Mood disorders Symptom dimensions 

Notes

Compliance with Ethical Standards

All reported studies with human subjects performed by the authors have been previously published and complied with all applicable ethical standards, including the Helsinki declaration and its amendments, institutional review board standards, and national guidelines.

Conflict of Interest

The authors declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

  1. 1.
    Hasin DS, Sarvet AL, Meyers JL, Saha TD, Ruan WJ, Stohl M, et al. Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United States. JAMA psychiatry. 2018;75(4):336–46.  https://doi.org/10.1001/jamapsychiatry.2017.4602.CrossRefPubMedGoogle Scholar
  2. 2.
    Steffens DC, Skoog I, Norton MC, Hart AD, Tschanz JT, Plassman BL, et al. Prevalence of depression and its treatment in an elderly population: the Cache County study. Arch Gen Psychiatry. 2000;57(6):601–7.CrossRefGoogle Scholar
  3. 3.
    Girgus J, Yang K, Ferri C. The gender difference in depression: are elderly women at greater risk for depression than elderly men? Geriatrics. 2017;2(4):35.  https://doi.org/10.3390/geriatrics2040035.CrossRefGoogle Scholar
  4. 4.
    Steffens DC, Fisher GG, Langa KM, Potter GG, Plassman BL. Prevalence of depression among older Americans: the aging, Demographics and Memory Study. Int Psychogeriatr. 2009;21(5):879–88.  https://doi.org/10.1017/S1041610209990044.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Pickett YR, Bazelais KN, Bruce ML. Late-life depression in older African Americans: a comprehensive review of epidemiological and clinical data. Int J Geriatr Psychiatry. 2013;28(9):903–13.  https://doi.org/10.1002/gps.3908.CrossRefPubMedGoogle Scholar
  6. 6.
    Laborde-Lahoz P, El-Gabalawy R, Kinley J, Kirwin PD, Sareen J, Pietrzak RH. Subsyndromal depression among older adults in the USA: prevalence, comorbidity, and risk for new-onset psychiatric disorders in late life. Int J Geriatr Psychiatry. 2015;30(7):677–85.  https://doi.org/10.1002/gps.4204.CrossRefPubMedGoogle Scholar
  7. 7.
    Butters MA, Whyte EM, Nebes RD, Begley AE, Dew MA, Mulsant BH, et al. The nature and determinants of neuropsychological functioning in late-life depression. Arch Gen Psychiatry. 2004;61(6):587–95.  https://doi.org/10.1001/archpsyc.61.6.587.CrossRefPubMedGoogle Scholar
  8. 8.
    Weisenbach SL, Boore LA, Kales HC. Depression and cognitive impairment in older adults. Curr Psychiatry Rep. 2012;14(4):280–8.  https://doi.org/10.1007/s11920-012-0278-7.CrossRefPubMedGoogle Scholar
  9. 9.
    Hammar A, Ardal G. Cognitive functioning in major depression--a summary. Front Hum Neurosci. 2009;3:26.  https://doi.org/10.3389/neuro.09.026.2009.CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Lee RS, Hermens DF, Porter MA, Redoblado-Hodge MA. A meta-analysis of cognitive deficits in first-episode major depressive disorder. J Affect Disord. 2012;140(2):113–24.  https://doi.org/10.1016/j.jad.2011.10.023.CrossRefPubMedGoogle Scholar
  11. 11.
    Christensen H, Griffiths K, Mackinnon A, Jacomb P. A quantitative review of cognitive deficits in depression and Alzheimer-type dementia. J Int Neuropsychol Soc. 1997;3(6):631–51.PubMedGoogle Scholar
  12. 12.
    de Paula JJ, Bicalho MA, Avila RT, Cintra MT, Diniz BS, Romano-Silva MA, et al. A reanalysis of cognitive-functional performance in older adults: investigating the interaction between normal aging, mild cognitive impairment, mild Alzheimer’s disease dementia, and depression. Front Psychol. 2015;6:2061.  https://doi.org/10.3389/fpsyg.2015.02061.CrossRefPubMedGoogle Scholar
  13. 13.
    Dotson VM, Resnick SM, Zonderman AB. Differential association of concurrent, baseline, and average depressive symptoms with cognitive decline in older adults. Am J Geriatr Psychiatry. 2008;16(4):318–30.  https://doi.org/10.1097/JGP.0b013e3181662a9c.CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Elderkin-Thompson V, Mintz J, Haroon E, Lavretsky H, Kumar A. Executive dysfunction and memory in older patients with major and minor depression. Arch Clin Neuropsychol. 2007;22(2):261–70.  https://doi.org/10.1016/j.acn.2007.01.021.CrossRefPubMedGoogle Scholar
  15. 15.
    Graziane JA, Beer JC, Snitz BE, Chang CC, Ganguli M. Dual trajectories of depression and cognition: a longitudinal population-based study. Am J Geriatr Psychiatry. 2016;24(5):364–73.  https://doi.org/10.1016/j.jagp.2015.08.001.CrossRefPubMedGoogle Scholar
  16. 16.
    Sachs-Ericsson N, Corsentino E, Moxley J, Hames JL, Rushing NC, Sawyer K, et al. A longitudinal study of differences in late- and early-onset geriatric depression: depressive symptoms and psychosocial, cognitive, and neurological functioning. Aging Ment Health. 2013;17(1):1–11.  https://doi.org/10.1080/13607863.2012.717253.CrossRefPubMedGoogle Scholar
  17. 17.
    Rapp MA, Dahlman K, Sano M, Grossman HT, Haroutunian V, Gorman JM. Neuropsychological differences between late-onset and recurrent geriatric major depression. Am J Psychiatry. 2005;162(4):691–8.  https://doi.org/10.1176/appi.ajp.162.4.691.CrossRefPubMedGoogle Scholar
  18. 18.
    Mackin RS, Nelson JC, Delucchi KL, Raue PJ, Satre DD, Kiosses DN, et al. Association of age at depression onset with cognitive functioning in individuals with late-life depression and executive dysfunction. Am J Geriatr Psychiatry. 2014;22(12):1633–41.  https://doi.org/10.1016/j.jagp.2014.02.006.CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Herrmann LL, Goodwin GM, Ebmeier KP. The cognitive neuropsychology of depression in the elderly. Psychol Med. 2007;37(12):1693–702.  https://doi.org/10.1017/S0033291707001134.CrossRefPubMedGoogle Scholar
  20. 20.
    Bora E, Harrison BJ, Yucel M, Pantelis C. Cognitive impairment in euthymic major depressive disorder: a meta-analysis. Psychol Med. 2013;43(10):2017–26.  https://doi.org/10.1017/S0033291712002085.CrossRefPubMedGoogle Scholar
  21. 21.
    Dotson VM, Szymkowicz SM, Kirton JW, McLaren ME, Green ML, Rohani JY. Unique and interactive effect of anxiety and depressive symptoms on cognitive and brain function in young and older adults. Journal of depression & anxiety. 2014;Suppl 1. doi: https://doi.org/10.4172/2167-1044.S1-003.
  22. 22.
    Brailean A, Comijs HC, Aartsen MJ, Prince M, Prina AM, Beekman A, et al. Late-life depression symptom dimensions and cognitive functioning in the Longitudinal Aging Study Amsterdam (LASA). J Affect Disord. 2016;201:171–8.  https://doi.org/10.1016/j.jad.2016.05.027.CrossRefPubMedPubMedCentralGoogle Scholar
  23. 23.
    Brailean A, Aartsen MJ, Muniz-Terrera G, Prince M, Prina AM, Comijs HC, et al. Longitudinal associations between late-life depression dimensions and cognitive functioning: a cross-domain latent growth curve analysis. Psychol Med. 2017;47(4):690–702.  https://doi.org/10.1017/S003329171600297X.CrossRefPubMedGoogle Scholar
  24. 24.
    Geda YE, Knopman DS, Mrazek DA, Jicha GA, Smith GE, Negash S, et al. Depression, apolipoprotein E genotype, and the incidence of mild cognitive impairment: a prospective cohort study. Arch Neurol. 2006;63(3):435–40.  https://doi.org/10.1001/archneur.63.3.435.CrossRefPubMedGoogle Scholar
  25. 25.
    Sachdev PS, Lipnicki DM, Crawford J, Reppermund S, Kochan NA, Trollor JN, et al. Risk profiles for mild cognitive impairment vary by age and sex: the Sydney Memory and Ageing study. Am J Geriatr Psychiatry. 2012;20(10):854–65.  https://doi.org/10.1097/JGP.0b013e31825461b0.CrossRefPubMedGoogle Scholar
  26. 26.
    Sundermann EE, Katz MJ, Lipton RB. Sex differences in the relationship between depressive symptoms and risk of amnestic mild cognitive impairment. Am J Geriatr Psychiatry. 2017;25(1):13–22.  https://doi.org/10.1016/j.jagp.2016.08.022.CrossRefPubMedGoogle Scholar
  27. 27.
    O'Bryant SE, Hall JR, Cukrowicz KC, Edwards M, Johnson LA, Lefforge D, et al. The differential impact of depressive symptom clusters on cognition in a rural multi-ethnic cohort: a Project FRONTIER study. Int J Geriatr Psychiatry. 2011;26(2):199–205.  https://doi.org/10.1002/gps.2514.CrossRefPubMedGoogle Scholar
  28. 28.
    Carmasin JS, Mast BT, Allaire JC, Whitfield KE. Vascular risk factors, depression, and cognitive change among African American older adults. Int J Geriatr Psychiatr. 2014;29(3):291–8.  https://doi.org/10.1002/gps.4007.CrossRefGoogle Scholar
  29. 29.
    Raji MA, Reyes-Ortiz CA, Kuo YF, Markides KS, Ottenbacher KJ. Depressive symptoms and cognitive change in older Mexican Americans. J Geriatr Psychiatry Neurol. 2007;20(3):145–52.  https://doi.org/10.1177/0891988707303604.CrossRefPubMedGoogle Scholar
  30. 30.
    Zahodne LB, Nowinski CJ, Gershon RC, Manly JJ. Depressive symptoms are more strongly related to executive functioning and episodic memory among African American compared with non-Hispanic white older adults. Arch Clin Neuropsychol. 2014;29(7):663–9.  https://doi.org/10.1093/arclin/acu045.CrossRefPubMedPubMedCentralGoogle Scholar
  31. 31.
    Ji-Rong YMD, Bi-Rong DMD, Chang-Quang HMD, Hong-Mei WMD, Yan-Ling ZMD, Qing-Xiu LKS, et al. Cognitive impairment and depression among Chinese nonagenarians/centenarians. Am J Geriatr Psychiatry. 2010;18(4):297–304.  https://doi.org/10.1097/JGP.0b013e3181d143bc.CrossRefPubMedGoogle Scholar
  32. 32.
    Kim O. Cognitive impairment and depression in community-dwelling older Korean women. Psychol Rep. 2009;105(2):569–74.  https://doi.org/10.2466/pr0.105.2.569-574.CrossRefPubMedGoogle Scholar
  33. 33.
    McLaren ME, Szymkowicz SM, Kirton JW, Dotson VM. Impact of education on memory deficits in subclinical depression. Arch Clin Neuropsychol. 2015;30(5):387–93.  https://doi.org/10.1093/arclin/acv038.CrossRefPubMedPubMedCentralGoogle Scholar
  34. 34.
    Opdebeeck C, Nelis SM, Quinn C, Clare L. How does cognitive reserve impact on the relationships between mood, rumination, and cognitive function in later life? Aging Ment Health. 2015;19(8):705–12.  https://doi.org/10.1080/13607863.2014.962005.CrossRefPubMedGoogle Scholar
  35. 35.
    Bhalla RK, Butters MA, Zmuda MD, Seligman K, Mulsant BH, Pollock BG, et al. Does education moderate neuropsychological impairment in late-life depression? Int J Geriatr Psychiatry. 2005;20(5):413–7.  https://doi.org/10.1002/gps.1296.CrossRefPubMedGoogle Scholar
  36. 36.
    O'Shea DM, Fieo RA, Hamilton JL, Zahodne LB, Manly JJ, Stern Y. Examining the association between late-life depressive symptoms, cognitive function, and brain volumes in the context of cognitive reserve. Int J Geriatr Psychiatry. 2015;30(6):614–22.  https://doi.org/10.1002/gps.4192.CrossRefPubMedGoogle Scholar
  37. 37.
    Diniz BS, Butters MA, Albert SM, Dew MA, Reynolds CF 3rd. Late-life depression and risk of vascular dementia and Alzheimer’s disease: systematic review and meta-analysis of community-based cohort studies. The British journal of psychiatry : the journal of mental science. 2013;202(5):329–35.  https://doi.org/10.1192/bjp.bp.112.118307.CrossRefGoogle Scholar
  38. 38.
    Dotson VM, Beydoun MA, Zonderman AB. Recurrent depressive symptoms and the incidence of dementia and mild cognitive impairment. Neurology. 2010;75(1):27–34.  https://doi.org/10.1212/WNL.0b013e3181e62124.CrossRefPubMedPubMedCentralGoogle Scholar
  39. 39.
    Butters MA, Young JB, Lopez O, Aizenstein HJ, Mulsant BH, Reynolds CF 3rd, et al. Pathways linking late-life depression to persistent cognitive impairment and dementia. Dialogues Clin Neurosci. 2008;10(3):345–57.PubMedPubMedCentralGoogle Scholar
  40. 40.
    Amieva H, Le Goff M, Millet X, Orgogozo JM, Peres K, Barberger-Gateau P, et al. Prodromal Alzheimer’s disease: successive emergence of the clinical symptoms. Ann Neurol. 2008;64(5):492–8.  https://doi.org/10.1002/ana.21509.CrossRefPubMedGoogle Scholar
  41. 41.
    Chen P, Ganguli M, Mulsant BH, DeKosky ST. The temporal relationship between depressive symptoms and dementia: a community-based prospective study. Arch Gen Psychiatry. 1999;56(3):261–6.  https://doi.org/10.1001/archpsyc.56.3.261.CrossRefPubMedGoogle Scholar
  42. 42.
    Alexopoulos GS, Young RC, Meyers BS. Geriatric depression: age of onset and dementia. Biol Psychiatry. 1993;34(3):141–5.  https://doi.org/10.1016/0006-3223(93)90383-O.CrossRefPubMedGoogle Scholar
  43. 43.
    Bartolini M, Coccia M, Luzzi S, Provinciali L, Ceravolo MG. Motivational symptoms of depression mask preclinical Alzheimer’s disease in elderly subjects. Dement Geriatr Cogn Disord. 2005;19(1):31–6.  https://doi.org/10.1159/000080968.CrossRefPubMedGoogle Scholar
  44. 44.
    Jorm AF. History of depression as a risk factor for dementia: an updated review. Aust New Zeal J Psychiatr. 2001;35(6):776–81.  https://doi.org/10.1046/j.1440-1614.2001.00967.x.CrossRefGoogle Scholar
  45. 45.
    Chen Z, Skolnick P. Triple uptake inhibitors: therapeutic potential in depression and beyond. Expert Opin Investig Drugs. 2007;16(9):1365–77.  https://doi.org/10.1517/13543784.16.9.1365.CrossRefPubMedGoogle Scholar
  46. 46.
    Alexopoulos GS, Meyers BS, Young RC, Campbell S, Silbersweig D, Charlson M. ‘Vascular depression’ hypothesis. Arch Gen Psychiatry. 1997;54(10):915–22.  https://doi.org/10.1001/archpsyc.1997.01830220033006.CrossRefGoogle Scholar
  47. 47.
    Taylor WD, McQuoid DR, Payne ME, Zannas AS, MacFall JR, Steffens DC. Hippocampus atrophy and the longitudinal course of late-life depression. Am J Geriatr Psychiatry. 2014;22(12):1504–12.  https://doi.org/10.1016/j.jagp.2013.11.004.CrossRefPubMedGoogle Scholar
  48. 48.
    Sapolsky RM, Krey LC, McEwen BS. The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocr Rev. 1986;7(3):284–301.  https://doi.org/10.1210/edrv-7-3-284.CrossRefGoogle Scholar
  49. 49.
    Kim HK, Nunes PV, Oliveira KC, Young LT, Lafer B. Neuropathological relationship between major depression and dementia: a hypothetical model and review. Prog Neuro-Psychopharmacol Biol Psychiatry. 2016;67:51–7.  https://doi.org/10.1016/j.pnpbp.2016.01.008.CrossRefGoogle Scholar
  50. 50.
    Bell-McGinty S, Butters MA, Meltzer CC, Greer PJ, Reynolds CF, Becker JT. Brain morphometric abnormalities in geriatric depression: long-term neurobiological effects of illness duration. Am J Psychiat. 2002;159(8):1424–7.  https://doi.org/10.1176/appi.ajp.159.8.1424.CrossRefPubMedGoogle Scholar
  51. 51.
    Sexton CE, Mackay CE, Ebmeier KP. A systematic review and meta-analysis of magnetic resonance imaging studies in late-life depression. Am J Geriatr Psychiatry. 2013;21(2):184–95.  https://doi.org/10.1016/j.jagp.2012.10.019.CrossRefPubMedGoogle Scholar
  52. 52.
    Kumar A, Bilker W, Jin ZS, Udupa J. Atrophy and high intensity lesions: complementary neurobiological mechanisms in late-life major depression. Neuropsychopharmacol. 2000;22(3):264–74.  https://doi.org/10.1016/S0893-133x(99)00124-4.CrossRefGoogle Scholar
  53. 53.
    Crocco EA, Castro K, Loewenstein DA. How late-life depression affects cognition: neural mechanisms. Curr Psychiatr Rep. 2010;12(1):34–8.  https://doi.org/10.1007/s11920-009-0081-2.CrossRefGoogle Scholar
  54. 54.
    Szymkowicz SM, Woods AJ, Dotson VM, Porges EC, Nissim NR, O'Shea A, et al. Associations between subclinical depressive symptoms and reduced brain volume in middle-aged to older adults. Aging Ment Health. 2018:1–12.  https://doi.org/10.1080/13607863.2018.1432030.
  55. 55.
    Butters MA, Klunk WE, Mathis CA, Price JC, Ziolko SK, Hoge JA, et al. Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh compound-B. Alz Dis Assoc Dis. 2008;22(3):261–8.  https://doi.org/10.1097/WAD.0b013e31816c92bf.CrossRefGoogle Scholar
  56. 56.
    Kumar A, Kepe V, Barrio JR, Siddarth P, Manoukian V, Elderkin-Thompson V, et al. Protein binding in patients with late-life depression. Arch Gen Psychiat. 2011;68(11):1143–50.  https://doi.org/10.1001/archgenpsychiatry.2011.122 CrossRefPubMedGoogle Scholar
  57. 57.
    Sun XY, Mwamburi DM, Bungay K, Prasad J, Yee J, Lin YM, et al. Depression, antidepressants, and plasma amyloid beta (Beta) peptides in those elderly who do not have cardiovascular disease. Biol Psychiatry. 2007;62(12):1413–7.  https://doi.org/10.1016/j.biopsych.2007.01.003.CrossRefPubMedGoogle Scholar
  58. 58.
    Pomara N, Bruno D, Sarreal AS, Hernando RT, Nierenberg J, Petkova E, et al. Lower CSF amyloid beta peptides and higher F2-isoprostanes in cognitively intact elderly individuals with major depressive disorder. Am J Psychiatry. 2012;169(5):523–30.  https://doi.org/10.1176/appi.ajp.2011.11081153.CrossRefPubMedPubMedCentralGoogle Scholar
  59. 59.
    Graff-Radford NR, Crook JE, Lucas J, Boeve BF, Knopman DS, Ivnik RJ, et al. Association of low plasma Abeta42/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease. Arch Neurol. 2007;64(3):354–62.  https://doi.org/10.1001/archneur.64.3.354.CrossRefPubMedGoogle Scholar
  60. 60.
    Nascimento KK, Silva KP, Malloy-Diniz LF, Butters MA, Diniz BS. Plasma and cerebrospinal fluid amyloid-beta levels in late-life depression: a systematic review and meta-analysis. J Psychiatr Res. 2015;69:35–41.  https://doi.org/10.1016/j.jpsychires.2015.07.024.CrossRefPubMedPubMedCentralGoogle Scholar
  61. 61.
    Yamazaki C, Tamaoki T, Nunomura A, Tamai K, Yasuda K, Motohashi N. Plasma amyloid-beta and Alzheimer’s disease-related changes in late-life depression. J Alzheimers Dis. 2017;58(2):349–54.  https://doi.org/10.3233/JAD-170111.CrossRefPubMedGoogle Scholar
  62. 62.
    Zubenko GS, Henderson R, Stiffler JS, Stabler S, Rosen J, Kaplan BB. Association of the APOE epsilon 4 allele with clinical subtypes of late life depression. Biol Psychiatry. 1996;40(10):1008–16.  https://doi.org/10.1016/S0006-3223(96)00046-7.CrossRefPubMedGoogle Scholar
  63. 63.
    Butters, M. A., Sweet, R. A., Mulsant, B. H., Ilyas Kamboh, M., Pollock, B. G., Begley, A. E., . . . DeKosky, S. T. (2003). APOE is associated with age-of-onset, but not cognitive functioning, in late-life depression. Int J Geriatr Psychiatry, 18(12), 1075-1081.  https://doi.org/10.1002/gps.1006.
  64. 64.
    Irie F, Masaki KH, Petrovitch H, Abbott RD, Ross GW, Taaffe DR, et al. Apolipoprotein E epsilon 4 allele genotype and the effect of depressive symptoms on the risk of dementia in men. Arch Gen Psychiat. 2008;65(8):906–12.  https://doi.org/10.1001/archpsyc.65.8.906.CrossRefPubMedGoogle Scholar
  65. 65.
    Sen S, Duman R, Sanacora G. Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol Psychiatry. 2008;64(6):527–32.  https://doi.org/10.1016/j.biopsych.2008.05.005.CrossRefPubMedPubMedCentralGoogle Scholar
  66. 66.
    Frodl T, Schule C, Schmitt G, Born C, Baghai T, Zill P, et al. Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression. Arch Gen Psychiatry. 2007;64(4):410–6.  https://doi.org/10.1001/archpsyc.64.4.410.CrossRefPubMedGoogle Scholar
  67. 67.
    Dwivedi Y. Involvement of brain-derived neurotrophic factor in late-life depression. Am J Geriatr Psychiatry. 2013;21(5):433–49.  https://doi.org/10.1016/j.jagp.2012.10.026.CrossRefPubMedPubMedCentralGoogle Scholar
  68. 68.
    Leonard BE. Inflammation, depression and dementia: are they connected? Neurochem Res. 2007;32(10):1749–56.  https://doi.org/10.1007/s11064-007-9385-y.CrossRefPubMedGoogle Scholar
  69. 69.
    Thomas AJ, Davis S, Morris C, Jackson E, Harrison R, O’Brien JT. Increase in interleukin-1beta in late-life depression. Am J Psychiatry. 2005;162(1):175–7.  https://doi.org/10.1176/appi.ajp.162.1.175.CrossRefPubMedGoogle Scholar
  70. 70.
    Valkanova V, Ebmeier KP, Allan CL. CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies. J Affect Disord. 2013;150(3):736–44.  https://doi.org/10.1016/j.jad.2013.06.004.CrossRefPubMedGoogle Scholar
  71. 71.
    Goodkind MS, Gallagher-Thompson D, Thompson LW, Kesler SR, Anker L, Flournoy J, et al. The impact of executive function to cognitive behavioral therapy in late-life depression. Int J Geriatr Psychiatr. 2016;31(4):334–9.  https://doi.org/10.1001/archgenpsychiatry.2011.122.CrossRefGoogle Scholar
  72. 72.
    Morimoto SS, Wexler BE, Liu J, Hu W, Seirup J, Alexopoulos GS. Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression. Nat Commun. 2014;5:4579.  https://doi.org/10.1038/ncomms5579.CrossRefPubMedPubMedCentralGoogle Scholar
  73. 73.
    Mace RA, Gansler DA, Suvak MK, Gabris CM, Arean PA, Raue PJ, et al. Therapeutic relationship in the treatment of geriatric depression with executive dysfunction. J Affect Disord. 2017;214:130–7.  https://doi.org/10.1016/j.jad.2017.03.006.CrossRefPubMedPubMedCentralGoogle Scholar
  74. 74.
    Rhyner KT, Watts A. Exercise and depressive symptoms in older adults: a systematic meta-analytic review. J Aging Phys Act. 2016;24(2):234–46.  https://doi.org/10.1123/japa.2015-0146.CrossRefPubMedGoogle Scholar
  75. 75.
    Greer TL, Furman JL, Trivedi MH. Evaluation of the benefits of exercise on cognition in major depressive disorder. Gen Hosp Psychiatry. 2017;49:19–25.  https://doi.org/10.1016/j.genhosppsych.2017.06.002.CrossRefPubMedGoogle Scholar
  76. 76.
    Park S-H, Han KS, Kang C-B. Effects of exercise programs on depressive symptoms, quality of life, and self-esteem in older people: a systematic review of randomized controlled trials. Appl Nurs Res. 2014;27(4):219–26.  https://doi.org/10.1016/j.apnr.2014.01.004.CrossRefPubMedGoogle Scholar
  77. 77.
    Neviani F, Belvederi Murri M, Mussi C, Triolo F, Toni G, Simoncini E, et al. Physical exercise for late life depression: effects on cognition and disability. Int Psychogeriatr. 2017;29(7):1105–12.  https://doi.org/10.1017/S1041610217000576.CrossRefPubMedGoogle Scholar
  78. 78.
    Morimoto SS, Kanellopoulos D, Manning KJ, Alexopoulos GS. Diagnosis and treatment of depression and cognitive impairment in late life. Ann New York Acad Sci. 2015;1345:36–46.  https://doi.org/10.1111/nyas.12669.CrossRefGoogle Scholar
  79. 79.
    Doraiswamy PM, Krishnan KRR, Oxman T, Jenkyn LR, Coffey DJ, Burt T, et al. Does antidepressant therapy improve cognition in elderly depressed patients. J Gerontol. 2003;58A(12):1137–44.  https://doi.org/10.1093/gerona/58.12.M1137.CrossRefGoogle Scholar
  80. 80.
    Vieta E, Sluth LB, Olsen CK. The effects of vortioxetine on cognitive dysfunction in patients with inadequate response to current antidepressants in major depressive disorder: a short-term, randomized, double-blind, exploratory study versus escitalopram. J Affect Disord. 2018;227:803–9.  https://doi.org/10.1016/j.jad.2017.11.053.CrossRefPubMedGoogle Scholar
  81. 81.
    Keefe RS, McClintock SM, Roth RM, Doraiswamy PM, Tiger S, Madhoo M. Cognitive effects of pharmacotherapy for major depressive disorder: a systematic review. J Clin Psychiatry. 2014;75(8):864–76.  https://doi.org/10.4088/JCP.13r08609.CrossRefPubMedGoogle Scholar
  82. 82.
    Gray SL, Lai KV, Larson EB. Drug-induced cognition disorders in the elderly. Drug Saf. 1999;21(2):101–22.  https://doi.org/10.2165/00002018-199921020-00004.CrossRefPubMedGoogle Scholar
  83. 83.
    Knegtering H, Eijck M, Huijsman A. Effects of antidepressants on cognitive functioning of elderly patients. Drugs Aging. 1994;5(3):192–9.  https://doi.org/10.2165/00002512-199405030-00005.CrossRefPubMedGoogle Scholar
  84. 84.
    Lavretsky H, Reinlieb M, St. Cyr N, Siddarth P, Ercoli LM, Senturk D. Citalopram, methylphenidate, or their combination in geriatric depression: a randomized, double-blind, placebo controlled trial. Am J Psychiat 2015;172(6):561–569.  https://doi.org/10.1176/appi.ajp.2014.14070889.CrossRefGoogle Scholar
  85. 85.
    Rosenblat JD, Kakar R, McIntryre RS. The cognitive effects of antidepressants in major depressive disorder: a systematic review and meta-analysis of randomized controlled trials. Int J Neuropsychopharmacol. 2015;19(2):1–13.Google Scholar
  86. 86.
    Kellner CH, Husain MM, Knapp RG, McCall WV, Petrides G, Rudorfer MV, et al. Right unilateral ultrabrief pulse ECT in geriatric depression: phase 1 of the PRIDE study. Am J Psychiat. 2016;173(11):1101–9.CrossRefGoogle Scholar
  87. 87.
    McClintock S, Staub B, Husain M. The effects of electroconvulsive therapy on neurocognitive function in elderly adults. Annals of Long-Term Care: Clinical Care and Aging. 2011;19(3):32–8.Google Scholar
  88. 88.
    McClintock SM, Choi J, Deng ZD, Appelbaum LG, Krystal AD, Lisanby SH. Multifactorial determinants of the neurocognitive effects of electroconvulsive therapy. Journal of ECT. 2014;30:165–76.CrossRefGoogle Scholar
  89. 89.
    Tor P-C, Bautovich A, Wang M-J, Martin D, Harvey SB, Loo C. A systematic review and meta-analysis of brief versus ultrabrief right unilateral electroconvulsive therapy for depression. J Clin Psychiatry. 2015;76(9):e1092–e8.CrossRefGoogle Scholar
  90. 90.
    Lisanby SH, McClintock SM, Knapp R, Mueller M, Greenberg RM, Rudorfer MV, et al. Neurocognitive effects of combined electroconvulsive therapy and venlafaxine in elderly adults with major depressive disorder. Neuropsychopharmacology. 2016;41:S364.Google Scholar
  91. 91.
    Osler M, Rozing MP, Christensen GT, Andersen PK, Jorgensen MB. Electroconvulsive therapy and risk of dementia in patients with affective disorders: a cohort study. Lancet Psychiatry. 2018;5(4):348–56.CrossRefGoogle Scholar
  92. 92.
    Moshe I, Daskalakis ZJ, Kumar S, Rajji TK, Blumberger DM. Clinical effectiveness and tolerability of electroconvulsive therapy in patients with neuropsychiatric symptoms of dementia. J Alzheimers Dis. 2017;57(1):45–51.CrossRefGoogle Scholar
  93. 93.
    Iriarte IG, George MS. Transcranial magnetic stimulation in the elderly. Current psychiatry reports. 2018;20(6).Google Scholar
  94. 94.
    McClintock SM, Reti IM, Carpenter LL, McDonald WM, Dubin M, Taylor SF, et al. Consensus recommendations for the clinical application of repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression. J Clin Psychiatry. 2018;79(1):35–48.CrossRefGoogle Scholar
  95. 95.
    Wassermann EM, Zimmermann T. Transcranial magnetic brain stimulation: therapeutic promises and scientific gaps. Pharmacol Ther. 2012;133(1):98–107.CrossRefGoogle Scholar
  96. 96.
    Serafini G, Pompili M, Belvederi Murri M, Respino M, Ghio L, Girardi P, et al. The effects of repetitive transcranial magnetic stimulation on cognitive performance in treatment-resistant depression. Syst Rev Neuropsychobiology. 2015;71(3):125–39.CrossRefGoogle Scholar
  97. 97.
    Martin DM, McClintock SM, Forster JJ, Lo TY, Loo CK. Cognitive enhancing effects of rTMS administered to the prefrontal cortex in patients with depression: a systematic review and meta-analysis of individual task effects. Depression Anxiety. 2017;34(11):1029–39.CrossRefGoogle Scholar
  98. 98.
    Martin DM, MS M, Forster J, Loo CK. Does therapeutic repetitive transcranial magnetic stimulation cause cognitive enhancing effects in patients with neuropsychiatric conditions? A systematic review and meta-analysis of randomised controlled trials. Neuropsychol Rev. 2016;26(3):295–309.CrossRefGoogle Scholar
  99. 99.
    Luber B, Lisanby SH. Enhancement of human cognitive performance using transcranial magnetic stimulation (TMS). NeuroImage. 2014;85:961–70.  https://doi.org/10.1016/j.neuroimage.2013.06.007.CrossRefPubMedGoogle Scholar
  100. 100.
    Cheng CPW, Wong CSM, Lee KK, Chan APK, Yeung JWF, Chan WC. Effects of repetitive transcranial magnetic stimulation on improvement of cognition in elderly patients with cognitive impairment: a systematic review and meta-analysis. Int J Geriatr Psychiatr. 2018;33(1):e1–e13.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Vonetta M. Dotson
    • 1
    • 2
  • Sarah M. Szymkowicz
    • 3
  • Joseph U. Kim
    • 4
  • Shawn M. McClintock
    • 5
    • 6
  1. 1.Department of PsychologyGeorgia State UniversityAtlantaUSA
  2. 2.Gerontology InstituteGeorgia State UniversityAtlantaUSA
  3. 3.Department of Clinical and Health PsychologyUniversity of FloridaGainesvilleUSA
  4. 4.Department of PsychiatryUniversity of Utah School of MedicineSalt Lake CityUSA
  5. 5.Neurocognitive Research Laboratory, Department of PsychiatryUniversity of Texas Southwestern Medical CenterDallasUSA
  6. 6.Department of Psychiatry and Behavioral SciencesDuke University School of MedicineDurhamUSA

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